Wyniki wyszukiwania

1

„Pamięć metaboliczna” – epigenetyczne modyfikacje materiału jądrowego jako przyczyna powikłań cukrzycy

100%

Dembinska-Kiec A.

Diagnostyka Laboratoryjna

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2011

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tom 47

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nr 3

2

Nutrient sensors, their polymorphism as the metabolic control and risk for cardiovascular disorders

88%

Dembinska-Kiec A.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

3

DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells

51%

Kiec-Wilk B., Razny U., Mathers J. C., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

49-53

DNA methylation is a potent regulator of gene expression. The influence of beta-carotene (BC) and arachidonic acid (AA) on angiogenesis - a new blood vessel formation, was reported. The tyrosine kinase VEGFR-2 receptor (KDR) activation by vascular endothelial growth factor is one of the main angiogenic mechanisms. This study was aimed to investigate a possible role of CpG island methylation on regulation of the pro-angiogenic KDR gene expression after incubation of human endothelial cells with BC and/or AA. Methods: Human umbilical vein endothelial cells (HUVEC) were incubated with BC (1-10 µM) and/or 3 µM AA for 24 hours. The CpG island methylation was quantified using the COBRA method and restriction enzymes' digestion (NewEngland BioLabs). Intracellular protein concentrations were determined by Western blot analysis using the specific antibodies (Santa Cruz). Results: Incubation with BC and AA, decreased methylation of the KDR promoter region. These results well-correlated with the detected, by qRT-PCR, up-regulation of KDR gene expression by BC (p=0.035) as well as by AA. Incubation with BC (p=0.02) and AA (p=0.0014) increased the KDR protein levels in HUVECs. Conclusion: The changes in CpG island methylation of the KDR the pro-angiogenic gene promoter, represents one of the mechanisms involved in regulation of angiogenic response by BC and AA.

4

Rola czynników genetycznych w rozwoju otyłości

51%

Malczewska M., Dembinska-Kiec A., Malec K.

Prace Komisji Nauk Rolniczych, Leśnych i Weterynaryjnych. Polska Akademia Umiejętności

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2010

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tom 12

5

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Labile products of vascular endothelium as mediators and modulators of the functions of the central nervous system

51%

Dembinska-Kiec A., Goscinski I., Szczudlik A.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 2

6

Acid and neutral lipase activity in lymphocytes of patients with increased serum cholesterol and triglyceride level

51%

Miszczuk-Jamska B., Chevalier F., Maire I., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 4

7

The chemotactic activity of beta-carotene in endothelial cell progenitors and HUVEC. The microarray analysis

45%

Polus A., Hartwich J., Kiec-Wilk B., Mikolajczyk M., Dembinska-Kiec A.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

8

Differentiation of human adipose tissue progenitors to adipocytes or endothelial cells using different culture conditions

45%

Balwierz A., Czech U., Polus A., Dudek W., Dembinska-Kiec A.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

9

Ranking of redox potential between CHD risk factors. Plasma ischemia modified albumin (IMA), hsCRP and Chlamydia pneumoniae seropositivity in obese/metabolic syndrome patients

45%

Hartwich J., Goralska J. M., Siedlecka D., Zawilinska B., Dembinska-Kiec A.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

10

Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)

45%

Wybranska I.-I., Malec M.-M., Leszczynska I.-G., Kiec-wilk B., Dembinska-Kiec A.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

11

The activity of constitutive nitric oxide synthase in prefrontal cortex of rats as an exponent of emotional state before death

45%

Hauser R., Gos T., Hartwich J., Krzyzanowski M., Dembinska-Kiec A.

Acta Neurobiologiae Experimentalis

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1999

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tom 59

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nr 3

12

The selected pathophysiological aspects of PPARs activation

45%

Kiec-Wilk B., Dembinska-Kiec A., Olszanecka A., Bodzioch M., Kawecka-Jaszcz K.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 2

Peroxisome proliferator activated receptors (PPARs) belong to a subfamily of transcription nuclear factors. Three isoforms of PPARs have been identified: alpha, ß/ and , encoded by different genes and distributed in various tissues. They play important roles in metabolic processes like regulation of glucose and lipid redistribution. They also have anti-atherogenic, anti-inflammatory as well as anti-hypertensive functions. In hypertension-induced cardiac hypertrophy, both PPARalpha and PPAR activation reveal cardio-protective effect. Despite these beneficial functions, several recent experimental reports point to the possibille unfavorable effects of PPARs activation in lipid metabolism (lipotoxicity) in cardiomyocytes, which can lead to pathologic cardiac hypertrophy in such diseases as diabetes type 2, metabolic syndrome or obesity. This paper reviews evidences and hypotheses about the new pathophysiological aspects of PPARs activation.

13

Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages

45%

Jozkowicz A., Dulak J., Piatkowska E., Placha W., Dembinska-Kiec A.

Acta Biochimica Polonica

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2000

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tom 47

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nr 4

Peroxisome proliferator-activated receptors-gamma (PPARgamma) are ligand-inducible transcription factors of the nuclear hormone receptor superfamily. We examined the effect of PPARgamma activation on the generation of vascular endothelial growth factor (VEGF), one of the major angiogenic agents. Rat vascular smooth muscle cells (VSMC) and murine macrophages RAW264.7 were incubated for 24 h with PPARgamma activators: prostaglandin J2 and ciglitazone. PPARgamma were expressed in VSMC and RAW cells and their activity was upregulated in the presence of PGJ2 and ciglitazone. Incubation of the cells with PPARgamma activators significantly augmented the release of VEGF protein into the media, both in resting and in IL-1beta- or LPS-stimulated cultures. The higher protein generation was connected with the increased expression of mRNA and transcriptional activation of VEGF promoter. We conclude that the activation of PPARgamma upregulates the generation of VEGF and may be involved in the regulation of angiogenesis.

14

Relation between expression of TNF alpha, iNOS, VEGF mRNA and development of heart failure after experimental myocardial infarction in rats

45%

Heba G., Krzeminski T., Porc M., Grzyb J., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 1

15

Modulation of LDL catabolism by sodium nitroprusside and [PGE2] in human peripheral blood lymphocytes

45%

Miszczuk-Jamska B., Wybranska I., Hartwich J., Dembinska-Kiec A., Gryglewski R. J.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 2

16

Antioxidants quercetin and beta carotene can modulate mitochondrial function of human preadipocytes

39%

Sliwa A., Goralska J., Czech U., Gruca A., Knapp A., Dembinska-Kiec A.

Acta Biologica Cracoviensia. Series Botanica. Supplement

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2011

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tom 53

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nr 1

17

CpG islands methylation induced by betacarotene and arachidonic acid in human endothelial cells and its progenitors

39%

Kiec-Wilk B., Polus A., Mikolajczyk M., Hartwich J., Mathers J., Dembinska-Kiec A.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

18

Modulation of the human preadipocyte mitochondrial activity by beta-carotene

39%

Sliwa A., Goralska J., Czech U., Gruca A., Polus A., Zapala B., Dembinska-Kiec A.

Acta Biochimica Polonica

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2012

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tom 59

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nr 1

Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria.

19

Eicosapentaenoic acid as mitochondria protective agent in endothelial cells exposed to stress

39%

Goralska J., Sliwa A., Zapala B., Gruca A., Czech U., Awsiuk M., Dembinska-Kiec A.

Polish Journal of Food and Nutrition Sciences

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2011

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tom 61

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nr Suppl.1

20

Beta-carotene, and metabolic effect of fatty acids on the Connexin 43 expression in stressed endothelial cells.

39%

Kiec-Wilk B., Knapp A., Goralska J., Awsiuk M., Sliwa A., Staszel T., Dembinska-Kiec A.

Acta Biologica Cracoviensia. Series Botanica. Supplement

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2011

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tom 53

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nr 1

Ograniczanie wyników

„Pamięć metaboliczna” – epigenetyczne modyfikacje materiału jądrowego jako przyczyna powikłań cukrzycy

Nutrient sensors, their polymorphism as the metabolic control and risk for cardiovascular disorders

DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells

Rola czynników genetycznych w rozwoju otyłości

Labile products of vascular endothelium as mediators and modulators of the functions of the central nervous system

Acid and neutral lipase activity in lymphocytes of patients with increased serum cholesterol and triglyceride level

The chemotactic activity of beta-carotene in endothelial cell progenitors and HUVEC. The microarray analysis

Differentiation of human adipose tissue progenitors to adipocytes or endothelial cells using different culture conditions

Ranking of redox potential between CHD risk factors. Plasma ischemia modified albumin (IMA), hsCRP and Chlamydia pneumoniae seropositivity in obese/metabolic syndrome patients

Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)

The activity of constitutive nitric oxide synthase in prefrontal cortex of rats as an exponent of emotional state before death

The selected pathophysiological aspects of PPARs activation

Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages

Relation between expression of TNF alpha, iNOS, VEGF mRNA and development of heart failure after experimental myocardial infarction in rats

Modulation of LDL catabolism by sodium nitroprusside and [PGE2] in human peripheral blood lymphocytes

Antioxidants quercetin and beta carotene can modulate mitochondrial function of human preadipocytes

CpG islands methylation induced by betacarotene and arachidonic acid in human endothelial cells and its progenitors

Modulation of the human preadipocyte mitochondrial activity by beta-carotene

Eicosapentaenoic acid as mitochondria protective agent in endothelial cells exposed to stress

Beta-carotene, and metabolic effect of fatty acids on the Connexin 43 expression in stressed endothelial cells.