Wyniki wyszukiwania

1

Raport PricewaterhouseCoopers

100%

Kruszewski M.

Poradnik Handlowca. Branżowy Miesięcznik Ogólnopolski dla Sklepów i Hurtowni FMCG

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2006

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tom 13

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nr 01

36-37

2

The role of labile iron pool in cardiovascular diseases

100%

Kruszewski M.

Acta Biochimica Polonica

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2004

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tom 51

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nr 2

Although multiple factors are associated with cardiovascular pathology, there is now an impressive body of evidence that free radicals and nonradical oxidants might cause a number of cardiovascular dysfunctions. Both direct damage to cellular components and/or oxidation of extracellular biomolecules, e.g. LDL, might be involved in the aetiology of cardiovascular diseases. The key molecules in this process seem to be iron and copper ions that catalyse formation of the highly reactive hydroxyl radical. Chelation of iron ions has a beneficial effect on the processes associated with the development of atherosclerosis and formation of post-ischemic lesions. These findings are indirectly supported by the increasing body of evidence that stored body iron plays a crucial role in pathogenesis of atherosclerosis and ischemia/reperfusion injury.

3

Cytotoxic and mutagenic effects of hydrogen peroxide in murine L5178Y sublines

63%

Kruszewski M., Szumiel I.

Acta Biochimica Polonica

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1993

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tom 40

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nr 1

4

Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines

63%

Kruszewski M., Iwanenko T.

Acta Biochimica Polonica

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2003

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tom 50

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nr 1

Labile iron pool (LIP) constitutes a crossroad of metabolic pathways of iron-containing compounds and is midway between the cellular need for iron, its uptake and storage. In this study we investigated oxidative DNA damage in relation to the labile iron pool in a pair of mouse lymphoma L5178Y (LY) sublines (LY-R and LY-S) differing in sensitivity to hydrogen peroxide. The LY-R cells, which are hydrogen peroxide-sensitive, contain 3 times more labile iron than the hydrogen peroxide-resistant LY-S cells. Using the comet assay, we compared total DNA breakage in the studied cell lines treated with hydrogen peroxide (25 uM for 30 min at 4°C). More DNA damage was found in LY-R cells than in LY-S cells. We also compared the levels of DNA lesions sensitive to specific DNA repair enzymes in both cell lines treated with H2O2. The levels of endonuclease Ill-sensitive sites and Fapy-DNA glycosylase-sensitive sites were found to be higher in LY-R cells than in LY-S cells.

5

DNA damage induced by hydrogen peroxide treatment at 4 st.C and 37 st.C in murine lymphoma L5178Y sublines

63%

Kruszewski M., Szumiel I.

Acta Biochimica Polonica

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1994

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tom 41

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nr 2

6

Induction of DNA breakage in X-irradiated nucleoids selectively stripped of nuclear proteins in two mouse lymphoma cell lines differing in radiosensitivity

63%

Kruszewski M., Iwanenko T.

Acta Biochimica Polonica

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1998

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tom 45

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nr 3

The role of nuclear proteins in protection of DNA against ionizing radiation and their contribution to the radiation sensitivity was examined by an alkaline version of comet assay in two L5178Y (LY) mouse lymphoma cell lines differing in sensitivity to ionizing radiation. LY-S cells are twice more sensitive to ionizing radiation than LY-R cells (D0 values of survival curves are 0.5 Gy and 1 Gy, respectively). Sequential removal of nuclear proteins by extraction with NaCl of different concentrations increased the X-ray induced DNA damage in LY-R nucleoids. In contrast, in the radiation sensitive LY-S cell line, depletion of nuclear proteins practically did not affect DNA damage. Although there is no doubt that the main cause of LY-S cells' sensitivity to ionizing radiation is a defect in the repair of double-strand breaks, our data support the concept that nuclear matrix organisation may contribute to the cellular susceptibility to DNA damaging agents.

7

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Środki ochrony roślin a zdrowie rolników – biomarkery oraz możliwości ich wykorzystania do oceny ekspozycji na pestycydy

51%

Kapka-Skrzypczak L., Cyranka M., Kruszewski M., Turski W. A.

Medycyna Ogólna i Nauki o Zdrowiu

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2011

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tom 17(46)

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nr 1

8

Iron-sulfur cluster proteins: electron transfer and beyond

51%

Brzoska K., Meczynska S., Kruszewski M.

Acta Biochimica Polonica

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2006

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tom 53

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nr 4

9

Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art

51%

Kapka-Skrzypczak L., Cyranka M., Skrzypczak M., Kruszewski M.

Annals of Agricultural and Environmental Medicine

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2011

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tom 18

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nr 2

10

Alder wood and its composites as a tribological material applied in kinematic pair with steel and cast iron

51%

Kruszewski M., Pohl P., Wieloch G.

Folia Forestalia Polonica. Series B - Drzewnictwo

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1996

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tom 27

31-40

11

Non-haem iron proteins: new functions of old pals

51%

Brzoska K., Meczynska S., Kruszewski M.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

12

The role of lysosomal iron in dinitrosyl iron complexes formation

51%

Meczynska S., Lewandowska H., Kruszewski M.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

13

Does the defect in NHEJ-mediated DSB repair pathway result in elevated frequency of homologous recombination?

51%

Wojewodzka M., Bartlomiejczyk T., Kruszewski M.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

14

The state of knowledge of dietary, physiological and pharmacological supplementation and the preferential use of these substances by persons practising recreational bodybuilding

51%

Kruszewski M., Jagiello W., Kutwin R.

Baltic Journal of Health and Physical Activity. The Journal of Gdansk University of Physical Education and Sport

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2012

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tom 04

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nr 3

Background: The aim of the study was to establish preferential use of dietary, physiological and pharmacological supplementation by persons practising recreational bodybuilding and to check whether it results from the respondents’ knowledge or whether it is accidental. Material/Methods: The group of subjects comprised 100 persons practising recreational bodybuilding in four well-known Lodz gyms. In the study the method of a diagnostic survey was used. A questionnaire containing 31 closed and opened questions constituted the research tool. Results: It was demonstrated that the state of knowledge concerning dietary supplementation is insufficient, despite its optimistic self-assessment, and because of that the preferences as to the applied nutrients are inappropriate. The knowledge of physiological supplementation substances and preferences of their use seem appropriate, although the multitude of the mentioned means can attest to information chaos in this respect. Results of the poll seem to show that the problem of illegal pharmacological supplementation refers not only to professional sports but also, unfortunately, to recreation. Conclusions: It is recommended to conduct a widespread informative action among persons practising recreational bodybuilding to make them aware of dietary supplementation. The majority of respondents have a sufficient level of knowledge of means of physiological supplementation, and preferences of using them seem correct. Even though the state of knowledge concerning health complications hazards when taking prohibited pharmacological supplementation should be regarded as high, still the majority of the subjects (58%) do not reject the possibility of using it. Inconsistencies of attitudes among persons practising bodybuilding recreationally manifest themselves through simultaneous support for anti-doping tests and the desire to take advantage of unlawful pharmacological supplementation.

15

Silver nanoparticles – allies or adversaries?

51%

Bartlomiejczyk T., Lankoff A., Kruszewski M., Szumiel I.

Annals of Agricultural and Environmental Medicine

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2013

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tom 20

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nr 1

Nanoparticles (NP) are structures with at least one dimension of less than 100 nanometers (nm) and unique properties. Silver nanoparticles (AgNP), due to their bactericidal action, have found practical applications in medicine, cosmetics, textiles, electronics, and other fields. Nevertheless, their less advantageous properties which make AgNP potentially harmful to public health or the environment should also be taken into consideration. These nanoparticles are cyto- and genotoxic and accumulate in the environment, where their antibacterial properties may be disadvantageous for agriculture and waste management. The presented study reviews data concerning the biological effects of AgNP in mammalian cells in vitro: cellular uptake and excretion, localization in cellular compartments, cytotoxicity and genotoxicity. The mechanism of nanoparticle action consists on induction of the oxidative stress resulting in a further ROS generation, DNA damage and activation of signaling leading to various, cell type-specific pathways to inflammation, apoptotic or necrotic death. In order to assure a safe application of AgNP, further detailed studies are needed on the mechanisms of the action of AgNP on mammalian cells at the molecular level.

16

Nonhomologous end-joining deficiency of L5178Y-S cells is not associated with mutation in the ABCDE autophosphorylation cluster

51%

Brzoska K., Kruszewski M., Szumiel I.

Acta Biochimica Polonica

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2006

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tom 53

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nr 1

Cells with mutated autophosphorylation sites in the ABCDE cluster of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are defective in the repair of ionising radiation-induced DSB, but show in an in vitro test the same DNA-PK activity as the cells possessing wild type enzyme. Nevertheless, the mutated DNA-PK is able to undergo ATP-dependent autophosphorylation and inactivation. This characteristics correspond well with the phenotypic features of the L5178Y-S (LY-S) cell line that is defective in DSB repair, shows a pronounced G1 phase radiosensitivity, but in which the level of DNA-PK activity present in total cell extracts is similar to that of its radioresistant counterpart L5178Y-R (LY-R) cell line. The purpose of this work was to examine the possible alterations in the sequence encoding the cluster of autophosphorylation sites in the DNA-dependent protein kinase in LY-S cells. Despite the presence of phenotypic features indicating the possibility of such alterations, no differences were found between the sequences coding for the autophosphorylation sites in L5178Y-R and L5178Y-S cells. In conclusion, the repair defect in LY-S cells is not related to the structure of the DNA-PK autophosphorylation sites (ABCDE casette).

17

Repair of gamma-ray-induced base damage in L5178Y sublines is damage type-dependent und unrelated to radiation sensitivity

51%

Kruszewski M., Zastawny T. H., Szumiel I.

Acta Biochimica Polonica

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2001

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tom 48

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nr 2

The L5178Y (LY) murine lym phoma sublines LY-R and LY-S are dif fer en tially sen si tive to ion iz ing ra di a tion. The high ra di a tion sen si tiv ity of LY-S cells is re lated to impaired rejoining of DNA double strand breaks. We found previously that the g-ray-induced base dam age is higher in the more radiosensitive LY-S subline. Here, we ex am ine the role of the re pair of ion iz ing ra di a tion in duced base dam age in re la tion to the radiosensitivity dif fer ence of these sublines. We used the GS/MS tech nique to es ti mate the re pair rates of six types of base damage in g-irradiated LY cells. All mod i fied DNA bases iden ti fied in the course ofthis study were typ i cal for ir ra di ated chromatin. The to tal amount of ini tial base dam age was higher in the ra di a tion sen si tive LY-S subline than in the ra di a tion re sis tant LY-R subline. The re pair rates of 5-OHMeUra, 5-OHCyt, 8-OHAde were sim i lar in both cell lines, the re pair rates of FapyAde and 8-OHGua were higher in the radiosensitive LY-S cell line, whereas the re pair of 5-OHUra was faster in its radio resistant coun ter part, the LY-R. Al to gether, the re pair rates of the g-ray-induced DNA base dam age in LY sublines are re lated nei ther to the ini tial amounts of the dam aged bases nor to the dif fer en tial le thal or mutagenic ef fects of ion iz ing ra di a tion in these sublines.

18

The modulation of iron regulatory protein 1 [IRP1] by nitric oxide [NO] in a pair of mouse lymphoma cell lines L5178Y displaying different control of iron metabolism

51%

Starzynski R. R., Drapier J. C., Kruszewski M., Lipinski P.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

19

Jubileusz 70-lecia urodzin profesor Ireny Szumiel

50%

Kruszewski M.

Postępy Biochemii

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2006

|

tom 52

|

nr 2

115-116

20

Iron, DNA damage and disease

50%

Kruszewski M.

Acta Biochimica Polonica

|

2007

|

tom 54

|

nr Supplement 4

Ograniczanie wyników

Raport PricewaterhouseCoopers

The role of labile iron pool in cardiovascular diseases

Cytotoxic and mutagenic effects of hydrogen peroxide in murine L5178Y sublines

Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines

DNA damage induced by hydrogen peroxide treatment at 4 st.C and 37 st.C in murine lymphoma L5178Y sublines

Induction of DNA breakage in X-irradiated nucleoids selectively stripped of nuclear proteins in two mouse lymphoma cell lines differing in radiosensitivity

Środki ochrony roślin a zdrowie rolników – biomarkery oraz możliwości ich wykorzystania do oceny ekspozycji na pestycydy

Iron-sulfur cluster proteins: electron transfer and beyond

Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art

Alder wood and its composites as a tribological material applied in kinematic pair with steel and cast iron

Non-haem iron proteins: new functions of old pals

The role of lysosomal iron in dinitrosyl iron complexes formation

Does the defect in NHEJ-mediated DSB repair pathway result in elevated frequency of homologous recombination?

The state of knowledge of dietary, physiological and pharmacological supplementation and the preferential use of these substances by persons practising recreational bodybuilding

Silver nanoparticles – allies or adversaries?

Nonhomologous end-joining deficiency of L5178Y-S cells is not associated with mutation in the ABCDE autophosphorylation cluster

Repair of gamma-ray-induced base damage in L5178Y sublines is damage type-dependent und unrelated to radiation sensitivity

The modulation of iron regulatory protein 1 [IRP1] by nitric oxide [NO] in a pair of mouse lymphoma cell lines L5178Y displaying different control of iron metabolism

Jubileusz 70-lecia urodzin profesor Ireny Szumiel

Iron, DNA damage and disease