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1

Szanse i zagrozenia niszowej turystyki na przykladzie Mierzei Wislanej [czesc I]

100%
Makowski M.
Ekopartner
|
2006
|
nr 03
34-35
2

Ocena oddziaływania na środowisko przedsięwzięć związanych z obronnością i bezpieczeństwem państwa realizowanych na terenach zamkniętych

100%
Makowski M.
Problemy Ocen Środowiskowych
|
2009
|
nr 3[46]
3

Efekty reklamy telewizyjnej a skutki konsumpcji

100%
Makowski M.
Handel Wewnętrzny
|
2016
|
tom 62
|
nr 2
Celem opracowania jest ukazanie efektów wykorzystania reklamy telewizyjnej w kontekście ich skutków – zachowań konsumentów. Wykorzystując literaturę krajową oraz zagraniczną, a także dane dotyczące działań reklamowych realizowanych w IV kw. 2015 roku przez jednego z oferentów produktów mleczarskich, przedstawiono uzyskiwane efekty reklamy – o charakterze ekonomicznym (marketingowym), a także behawioralnym i komunikacyjnym. W opracowaniu wykorzystano dane pochodzące z przeprowadzonego pod koniec 2015 roku sondażu bezpośredniego, skierowanego do klientów w placówkach handlowych w Gdańsku.
4

Szanse i zagrozenia niszowej turystyki na przykladzie rezerwatow przyrody Mierzei Wislanej [czesc II]

100%
Makowski M.
Ekopartner
|
2006
|
nr 04
32-33
5

Krajoobraz jako czynnik promujacy turystyke przyrodnicza [cz.2]

75%
Makowski M.
Ekopartner
|
2006
|
nr 02
34-35
6

Torfowiska w Izerach

75%
Makowski M.
Echa Leśne
|
2001
|
tom 26
|
nr 09
24-25
7

Biopreparaty BACTA-PUR System

63%
Malicka M., Makowski M.
Rada: Rolnictwo, Aktualności, Doradztwo, Analizy. Miesięcznik Wojewódzkiego Ośrodka Doradztwa Rolniczego w Bratoszewicach
|
1996
|
nr 09
18
8

Krajobraz jako nieodlaczny element ludzkiego isnienia [cz.1]

63%
Makowski M.
Ekopartner
|
2006
|
nr 01
30-31
9

Anti- and prooxidative properties of hormonal therapy

51%
Stetkiewicz T., Makowski M., Pertynski T.
Acta Toxicologica
|
2007
|
tom 15
|
nr 1
10

Slaska Fudzijama

50%
Makowski M.
Echa Leśne
|
2002
|
nr 11
25-26
11
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The spatial pattern and microsites requirements of Abies alba natural regeneration in the Karkonosze Mountains

45%
Szymura T. H., Dunajski A., Aman I., Makowski M., Szymura M.
Dendrobiology
|
2007
|
tom 58
51-57
Progeny of four adult silver firs, which were an admixture in Norway spruce (Picea abies) stand was, analyzed. The study was done in lower mountain zone of the Karkonosze (Giant Mts.) National Park (SW Poland). The seedlings occurred in two clumps related to the position of adult trees, whereas spatial pattern of the seedlings inside each clump was random. The seedlings were spaced mainly in distances 5–25 from the nearest adult tree. The maximal distance was up to 50 m. Most seedlings were established in accordance with main wind directions. Also, in these directions seedlings were more distant from adult trees than in other directions. The seedlings grew in better light environment (12% of PPFD) than average (9,6% PPFD). This effect was statistically significant. The height increment of the seedlings was low and was not correlated with light conditions. Similarly, there was not any correlation between the apical dominance ratio and light. The lack of this correspondence we attributed to browsing. The silver fir seedlings were significantly underrepresented in patches of Vaccinium myrtillus, on raw needles, under crown of adult trees and in concave micro-relief form. The underrepresentation in the places covered by canopy and in patches of bilberry we related to the indirect effect of continuous browsing, which leads to higher seedlings mortality in more shaded places and sites of stronger competition between forest floor vegetation and silver fir seedlings.
12

Direct tumor damage mechanisms of photodynamic therapy

39%
Nowis D., Makowski M., Stoklosa T., Legat M., Issat T., Golab J.
Acta Biochimica Polonica
|
2005
|
tom 52
|
nr 2
Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with visible light usually generated by laser sources. A third component of PDT is molecular oxygen which is required for the most effective antitumor effects. In the presence of the latter, light of an appropriate wavelength excites the photosensitizer thereby producing cytotoxic intermediates that damage cellular structures. PDT has been approved in many countries for the treatment of lung, esophageal, bladder, skin and head and neck cancers. The antitumor effects of this treatment result from the combination of direct tumor cell photodamage, destruction of tumor vasculature and activation of an immune response. The mechanisms of the direct photodamage of tumor cells, the signaling pathways that lead to apoptosis or survival of sublethaly damaged cells, and potential novel strategies of improving the antitumor efficacy of PDT are discussed.
13

Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity

39%
Pawelczak K., Makowski M., Kempny M., Dzik J. M., Golos B., Rode W., Rzeszotarska B.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 2
Synthesis and biological evaluation are described of seven new analogues (3-9) of two potent thymidylate synthase inhibitors, 10-propargyl-5,8-dideazafolate (1) and its 2-methyl-2-deamino congener ICI 198583 (2). While the new compunds 3 and 4 were analogues of 1 and 2, respectively, containing a p-aminobenzenesulfonyl residue in place of the p-aminobenzoic acid residue, the remaining 5 new compounds were ana­logues of 4 with the L-glutamic acid residue replaced by glycine (5), L-valine (6), L-alanine (7), L-phenylglycine (8) or L-norvaline (9). The new analogues were tested as inhibitors of thymidylate synthases isolated from tumour (Ehrlich carcinoma), para­site (Hymenolepis diminuta) and normal tissue (regenerating rat liver) and found to be weaker inhibitors than the parent 10-propargyl-5,8-dideazafolic acid. Selected new analogues, tested as inhibitors of growth of mouse leukemia L 5178Y cells, were less potent than the parent 10-propargyl-5,8-dideazafolic acid. Substitution of the glutamyl residue in compound 4 with L-norvaline (9) resulted in only a 5-fold stronger thymidylate synthase inhibitor, but a 40-fold weaker cell growth inhibitor.
14

Pioglitazone, a PPAR-gamma ligand, exerts cytostatic-cytotoxic effects against cancer cells, that do not result from inhibition of proteasome

33%
Mrowka P., Glodkowska E., Mlynarczuk-Bialy I., Bialy L., Kuckelkorn U., Nowis D., Makowski M., Legat M., Golab J.
Acta Biochimica Polonica
|
2008
|
tom 55
|
nr 1
Thiazolidinediones are oral antidiabetic agents that activate peroxisome proliferator-activated receptor-gamma (PPAR-γ) and exert potent antioxidant and anti-inflammatory properties. It has also been shown that PPAR-γ agonists induce G0/G1 arrest and apoptosis of malignant cells. Some of these effects have been suggested to result from inhibition of proteasome activity in target cells. The aim of our studies was to critically evaluate the cytostatic/cytotoxic effects of one of thiazolidinediones (pioglitazone) and its influence on proteasome activity. Pioglitazone exerted dose-dependent cytostatic/cytotoxic effects in MIA PaCa-2 cells. Incubation of tumor cells with pioglitazone resulted in increased levels of p53 and p27 and decreased levels of cyclin D1. Accumulation of polyubiquitinated proteins within cells incubated with pioglitazone suggested dysfunction of proteasome activity. However, we did not observe any influence of pioglitazone on the activity of isolated proteasome and on the proteolytic activity in lysates of pioglitazone-treated MIA PaCa-2 cells. Further, treatment with pioglitazone did not cause an accumulation of fluorescent proteasome substrates in transfected HeLa cells expressing unstable GFP variants. Our results indicate that pioglitazone does not act as a direct or indirect proteasome inhibitor.
15

Arboretum Trsteno

32%
Makowski M.
Echa Leśne
|
2001
|
tom 26
|
nr 03
22-23
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