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1

Social interactions in cats: regional brain monoamine distribution in dominant and submissive cats

100%
Krotewicz M., Romaniuk A.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 4
2

Neurochemical alterations after 8-OHDPAT and WAY-100635 administration into the dorsal raphe nucleus in rats

81%
Koprowska M., Krotewicz M., Stzrelczuk M.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
3

Age-related effects of inidbrain 5-HT1A receptors stimulation in rats

81%
Krotewicz M., Koprowska M., Strzelczuk M.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
4

Serotonin and corticosterone-neurochemical indicators of sterss

81%
Koprowska M., Krotewicz M., Strzelczak M.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
The anxiety tests are widely used to study behaviour of rats in the stress-inducing situation. The study presents a comparative analysis of the infl uence of different stressogenic stimuli on the serotonergic activity in the emotional brain regions and on plasma corticosterone concentration in rats. The animals were subject to two various behavioral tests, and subsequently the concentration of serotonin (5- HT), its metabolite 5 – hydroxyindoleacetic acid (5-HIAA) and of plasma corticosterone concentration were determined using highperformance liquid chromatography with electrochemical detection (HPLC-ED). Stressogenic stimuli in the tests performed were: light of high volume (light dark transition test – LDT) or open fi eld (open fi eld test – OF). HPLC-ED analysis showed a signifi cant increased of 5-HT level in the amygdala (AM) after using both tests. HPLCED analysis showed also an increased of 5-HIAA concentration in the frontal cortex (CTX), in the hippocampus (HI), in the AM after using the LDT-test and an increased of 5-HIAA concentration in the CTX and in the AM after using OF-test. Simultaneously, the analysis showed elevation of corticosterone concentration in rats exposed to LDT and OF. These results confi rm that serotonin and coricosterone participate in the regulation of emotional response and they are important neurochemical indicators of stress.
5

Age-related effects of 5HT1A receptors activation on seroton

81%
Krotewicz M., Strzelczuk M., Krotewicz M. K.
Acta Neurobiologiae Experimentalis
|
2015
|
tom 75
|
nr Supl.
BACKGROUND AND AIMS: Serotonin (5-HT) and its receptors are engaged in the regulation of the different brain functions. Pharmacological agents modifying central serotonin activity are effective in the treatment of brain dysfunctions. It has been also postulated that 5-HT is involved in the process of brain aging. The present study was designed to examine age-related effects of peripheral administration of 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), on serotonergic system activity in the brain of rats exposed to stressogenic conditions of transition test. METHODS: Regional brain concentration of 5-HT and 5-hydroxyindoleacetic acid of mature (12 months old) and aged (24 months old) rats exposed to transition test were examined using high performance liquid chromatography with electrochemical detection after ip administration of 8-OH-DPAT. Serotonin turnover was measured by 5-HIAA/5-HT ratio. RESULTS: We observed anxiolytic influence of 8-OH-DPAT administration in rats of both age (mature and aged). Peripheral administration of 8-OH-DPAT significantly decreased serotonin concentration in the brain regions of emotional-defensive system in mature rats. The serotonin turnover index was lower in the all studied brain regions of 12 months old animals. The results obtained for 24 months old rats were different. The administration of 8-OH-DPAT induced elevation of serotonin concentration while the analyzed turnover index was lower in the most studied brain regions of aged rats. CONCLUSIONS: The 5-HT1A receptors are postulated to be engaged in the emotional mechanisms, and above all in the fear/ anxiety mechanisms. The present study confirmed that hypothesis. Comparison of the behavioral data showed similar, independent of age, anxiolytic effect caused by administration of 5-HT1A receptor agonist. Simultaneously, the obtained data revealed age-related neurochemical differences after 5-HT1A receptors activation.
6

Neurophysiological relationship between anxiety and social rank

81%
Krotewicz M., Wieczorek M., Koprowska M., Strzelczuk M.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Social rank means that the individuals take various positions in a social group. The individuals high in the social rank have more social opportunities compared to those low in the hierarchy. Social rank may have important consequences for the hypothalamo-pituitary-adrenocortical (HPA) system activity. It is known that the noradrenergic brain neuronal activity is closely related to the control of the HPA system. In our previous studies we observed that the brain NA system is implicated in the control of social position. The obtained data showed that the low social status was correlated with enhance of noradrenaline release. These results suggested to us that the low ranking individuals were in an anxiety state induced by the presence of a high ranking animal, winner of competitive situation. The present study was designed to examine correlations between anxiety indices measured in the popular anxiety models and positions in the social rank. Rats were exposed to open field (OF), transitions (TT) and social competition (SCT) tests. In the SCT rats were paired accordingly to their body weight and time of sugar pellets eating. The comparison of behavioural indices revealed negative correlation between number of consumed pellets and frequency of locomotion registered in OF. Additionally, the analysis of behavioural indices showed positive correlation between number of consumed pellets and behavioural indices measured in TT. Obtained data revealed that braver individuals which willingly explored new arena were successful in the SCT while the animals attribute with anxiety were losers in the social competitive situation. It suggests that anxiety is rather a reason of low ranking position of individuals then an effect of social competition. The animals got better position for competition and receive higher social rank in pairs when previously had presented better exploratory activity in the “stress”-inducing situation.
7

Behavioral alterations after 8-OHDPAT and WAY-100635 administration into the dorsal raphe nucleus in rats

81%
Stzrelczuk M., Koprowska M., Krotewicz M.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
8

The role of clonidine in behavioral and corticosterone responses to social competition

81%
Krotewicz M., Koprowska M., Strzelczuk M.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
It is postulated that the noradrenergic brain neuronal activity is closely related to the control of the hypothalamo-pituitary-adrenocortical (HPA) system. Our previous observations showed that the brain noradrenergic system is implicated in the control of social position studied in social competition tests. In order to obtain some further evidence speaking for a specifi c role of noradrenaline system activity in the control of social position we studied the effects of administration of the α2-adrenoceptor agonist clonidine on social behavior analyzed in the social competition test. Simultaneously, the concentration of corticosterone (RIA) was measured in the plasma of rats after social competition test and tested individually. We used an acute social competition situation that consisted of simultaneous placing of two experimental rats into the familiar cage supplied with feeder of glucose pellets. The obtained data revealed that social competitive behavior was affected by peripherally administered clonidine. The animals got better position for competition and received higher social rank in pairs after stimulation of α2-drenoceptor. Plasma corticosterone concentration was elevated in rats injected peripherally with clonidine in comparison with individually tested rats. The obtained results suggest that stimulation of α2-adrenoceptor affects HPA system activity and may facilitate appearance of tendency to social confrontations in rats.
9

Age-related changes in fear behavior and regional brain monoamines distribution in rats

81%
Koprowska M., Krotewicz M., Romaniuk A., Strzelczuk M.
Acta Neurobiologiae Experimentalis
|
2004
|
tom 64
|
nr 2
10

Effects of 8-OHDPAT and UH-301 administrations into the dorsal raphe nucleus on fear behavior and regional brain monoamies distribution in rats

71%
Strzelczuk M., Koproska M., Krotewicz M., Romaniuk A., Wieczorek M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
11

Effects of 8-OH-DPAT administration on the social behavior and regional brain monoamine distribution in the submissive cats

71%
Krotewicz M., Koprowska M., Strzelczuk M., Romaniuk A., Wieczorek M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
12

Effects of 8-OHDPAT administration into the dorsal raph2nucleus and dorsal hippocampus on fear behavior and regional brain monoamines distribution in rats

71%
Wieczorek M., Romaniuk A., Koprowska M., Krotewicz M., Strzelczuk M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
13

Brain monoamines and GABA alterations evoked by the lightdark and shelter-seeking tests in rats.

71%
Koprowska M., Krotewicz M., Romaniuk A., Strzelczuk A., Wieczorek M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
14

Behavioral and neurochemical effects of yohimbine administration into the amygdala of rats

71%
Strzelczuk M., Dadura P., Krotewicz M., Wieczorek M., Koprowska M.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Yohimbine is an indol alkaloid obtained from the root of Rauwolfia serpentina or from the bark of Pausinystalia yohimbe tree. This alkaloid is extensively used to explore the role of alpha 2 – adrenoceptors in experimental and clinical studies. Yohimbine has been predominantly used as a pharmacological tool in treatment of men’s impotence. Moreover, it was proved that yohimbine induces anxiety states and defense reactions. The amygdala is a structure in brain corresponding to the experience anxiety. It is suggested that intra-amygdalar administration of yohimbine might result in anxiogenic effect. In our experiment we have studied effects of yohimbine administration into the central nucleus of amygdala on locomotion, exploratory behavior and the noradrenergic system activity. Our study consisted of three parts: implantation of cannulas into the central nucleus of the amygdala (AMC), elevated plus maze test and biochemical analyses. We have examined the content of biogenic amines in the main emotional structures in the brain. We observed that animals preferred closed to open arms of the elevated plus maze. Additionally, the obtained data showed that changes in the concentration of noradrenaline in the AMC and hippocampus are in line with changes in the concentration of serotonin. This may confirm thesis that yohimbine has an influence on serotoninergic transmission.
15

Behavioral and neurochemical alterations evoked by p-chlorophenylalanine application in rats examined in the light-dark crossing test

71%
Koprowska M., Krotewicz M., Romaniuk A., Strzelczuk M., Wieczorek M.
Acta Neurobiologiae Experimentalis
|
1999
|
tom 59
|
nr 1
16

Fear behavior and regional brain monoamines distribution after R[plus]-8-OHDPAT and R[plus]-UH-301 injections into the dorsal raphe nucleus in rats

71%
Koprowska M., Krotewicz M., Romaniuk A., Strzelczuk M., Wieczorek M.
Acta Neurobiologiae Experimentalis
|
2002
|
tom 62
|
nr 2
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