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1

Sorption of aqueous methylene blue, cadmium and lead onto biochars derived from scrap papers

100%
Xu X., Hu X., Ding Z., Gao B.
Polish Journal of Environmental Studies
|
2020
|
tom 29
|
nr 6
2

Distributions of polycyclic aromatic hydrocarbons in coal in China

88%
Gao B., Feng Q., Zhou L., Wu H., Alam E.
Polish Journal of Environmental Studies
|
2019
|
tom 28
|
nr 3
Groundwater level rises rapidly when mine drainage systems stop functioning after mine closures. Free-form polycyclic aromatic hydrocarbons (PAHs) in residual pillaring and abandoned mining levels could continue to migrate because of eluviation leaching. Moreover, other aquifers are polluted with mine water through mining-induced fractures, faults, and poorly sealed drill holes. Therefore, the distributions of 16-PAHs in raw coal mined in China and the factors influencing these distributions were analyzed to assist mine closures. The results showed that the average concentration of PAHs was 10.540±7.973 μg/g in the raw coal samples, and PAHs with low molecular weights had the highest abundances, accounting for 44% of the total PAH concentration obtained. The highest concentration of 16-PAHs was observed in bituminous coals, followed by that in lignite, and the lowest is anthracite. The influence factors analysis reveals that carbon content, volatile matter, H/C, and O/C have a significant effect on PAH content in raw coals. The volatile matter and molar ratio of H/C play a leading role in the changing process in 16 PAHs, accounting for more than 60% of the total contribution.
3

Isolation and characterization of novel human short-chain dehydrogenase-reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase

88%
Huang C., Wan B., Gao B., Hexige S., Yu L.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 2
279-289
Hydroxysteroid dehydrogenase belongs to the subfamily of short-chain dehydrogenases/reductases (SDR), and 11-β-hydroxysteroid dehydrogenase catalyzes the interconversion of inactive glucocorticoids (cortisone in human, dehydrocorticosterone in rodents) and active glucocorticoids (cortisol in human, corticosterone in rodents). We report here the cloning and characterization of a novel human SDR gene SCDR10B which encodes a protein with similarity to 11β-hydroxysteroid dehydrogenase 1. SCDR10B was isolated from a human brain cDNA library, and was mapped to chromosome 19p13.3 by browsing the UCSC genomic database. It contains an ORF with a length of 858 bp, encoding a protein with a transmembrane helix and SDR domain. Its molecular mass and isoelectric point are predicted to be 30.8 kDa and 10.3 kDa, respectively. SCDR10B protein is highly conserved in mammals and fish. Phylogenetic tree analysis indicated that SCDR10B stands for a new subgroup in the 11β-hydroxysteroid dehydrogenase family. Northern blot analysis showed that SCDR10B was highly expressed in brain, and a strong expression signal was detected in hippocampal neurons by immunohistochemical analysis. RT-PCR and immunohistochemical analysis showed that SCDR10B was up-regulated in lung-cancer cell lines and human lung cancer. SCDR10B can catalyze the dehydrogenation of cortisol in the presence of NADP+, and therefore it is a hydroxysteroid dehydrogenase.
4

Occurrence and health risk assessment of trace metals in desalinated seawater using two desalination technologies

76%
Gao B., Yu H., Gao J., Liu L., Wang Q., Zhu C., Wu W.
Polish Journal of Environmental Studies
|
2020
|
tom 29
|
nr 5
5

Genetic transformation and expression of Cry1Ac–Cry3A–NTHK1 genes in Populus × euramericana “Neva”

76%
Liu D., Zhang J., Dong Y., Zhang X., Yang M., Gao B.
Acta Physiologiae Plantarum
|
2016
|
tom 38
|
nr 07
6

Construction of high-efficiency transformation vector with multiple insect-resistant genes and expression in tobacco

76%
Yuan S., Dong Y., Zhang N., Ren Y., Yang M., Gao B.
Acta Physiologiae Plantarum
|
2017
|
tom 39
|
nr 01
7

Histone hyperacetylation may improve the preimplantation development and epigenetic status of cloned embryos

64%
Sun J., Cui K., Li Z., Gao B., Jiang J., Liu Q., Huang B., Shi D.
Reproductive Biology
|
2020
|
tom 20
|
nr 2
8

Polymorphisms in intron 1 of the porcine POU1F1 gene

64%
Song C. Y., Gao B., Teng S. H., Wang X. Y., Xie F., Chen G. H., Wang Z. Y., Jing R. B., Mao J. D.
Journal of Applied Genetics
|
2007
|
tom 48
|
nr 4
371-374
This study was conducted to detect polymorphisms in intron 1 of porcine POU1F1 (POU domain, class 1, transcription factor 1, Pit 1, renamed as POU1F1) by comparative sequencing. Within the intron, 23 sites of variation were identified, including 16 single-nucleotide substitutions, 4 single-nucleotide indels, 2 short (3-bp and 17-bp), and one long (313-bp) indels. Several important regulatory motifs were found within the 313-bp indel by in silico analysis. The 313-bp indel was next genotyped in 11 Chinese native pig breeds and 4 western meat-type pig breeds. The appearance of genotypes varied between breeds: among Chinese native breeds, no AA and AB genotypes were found in Tibetan, Lingao, Min, Rongchang, and Songliao Black pigs, no AA genotype was found in Fenjing and Leping Spotted pigs, whereas in Pietrain and Landrace there were no BB genotypes, and all 19 Duroc pigs were A A homozygotes. The western meat-type pigs had high A allele frequencies and the Chinese pigs had more B alleles, except Jianquhai pigs. A positive association of the AA genotype with birth weight was observed in a commercial pig line. This paper demonstrated that the genetic variation in intron 1 of the pig POU1F1 gene was high and these polymorphisms may provide useful makers for QTL analysis.
9

Mspl polymorphisms in the 3rd intron of the swine POU1F1 gene and their associations with growth performance

64%
Song C., Gao B., Teng Y., Wang X., Wang Z., Li Q., Mi H., Jing R., Mao J.
Journal of Applied Genetics
|
2005
|
tom 46
|
nr 3
285-289
The study aimed to compare Mspl polymorphisms in the 3rd intron of the porcine gene encoding the pituitary-1 transcription factor (Pit-1, renamed as POU1F1) among 5 breeds and to determine the associations between its genotypes and growth performance in a commercial pig population by using the PCR-RFLP technique. Significant differences in genotypie and allelic frequencies were found between the meat-type and fat-type breeds (P < 0.05), and between miniature pigs and others (P < 0.05). No breed deviated from the Hardy-Weinberg equilibrium (verified by chi-square test). The general linear model analysis revealed that higher body weight on day 180 (BW180) and average daily gain (ADG) were significantly associated with POU1F1 DD genotype (P < 0.05). The differences in BW180 and ADG between DD pigs and both CD and CC pigs were significant (P < 0.05), and the DD pigs had a significantly higher body weight on day 45 (BW45) and on day 70 (BW70) than CC pigs (P < 0.05). All measured growth traits, except for body weight at birth (BWB), showed higher values in DD pigs. The D allele had a favorable positive effect on growth traits. Thus POU1F1 is a potential major gene or marker for growth traits.
10

Missense mutations in IHH impair Indian hedgehog signaling in C3H10T1-2 cells: implications for brachydactyly type A1, and new targets for hedgehog signaling

52%
Guo S., Zhou J., Gao B., Hu J., Wang H., Meng J., Zhao X., Ma G., Lin C., Xiao Y., Tang W., Zhu X., Cheah K. S. E., Feng G., Chan D., He L.
Cellular and Molecular Biology Letters
|
2010
|
tom 15
|
nr 1
153-176
Heterozygous missense mutations in IHH result in Brachydactyly type A1 (BDA1; OMIM 112500), a condition characterized by the shortening of digits due to hypoplasia/aplasia of the middle phalanx. Indian Hedgehog signaling regulates the proliferation and differentiation of chondrocytes and is essential for endochondral bone formation. Analyses of activated IHH signaling in C3H10T1/2 cells showed that three BDA1-associated mutations (p.E95K, p.D100E and p.E131K) severely impaired the induction of targets such as Ptch1 and Gli1. However, this was not a complete loss of function, suggesting that these mutations may affect the interaction with the receptor PTCH1 or its partners, with an impact on the induction potency. From comparative microarray expression analyses and quantitative real-time PCR, we identified three additional targets, Sostdc1, Penk1 and Igfbp5, which were also severely affected. Penk1 and Igfbp5 were confirmed to be regulated by GLI1, while the induction of Sostdc1 by IHH is independent of GLI1. SOSTDC1 is a BMP antagonist, and altered BMP signaling is known to affect digit formation. The role of Penk1 and Igfbp5 in skeletogenesis is not known. However, we have shown that both Penk1 and Igfbp5 are expressed in the interzone region of the developing joint of mouse digits, providing another link for a role for IHH signaling in the formation of the distal digits.
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