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1

Effects of chronic forced swim stress on hippocampal brainderived neutrophic factor (BDNF) and its receptor (TrkB) immunoreactive cells in juvenile and aged rats

100%
Badowska-Szalewska E., Spodnik E., Klejbor I., Morys J.
Acta Neurobiologiae Experimentalis
|
2010
|
tom 70
|
nr 4
A type of stress stimulation and age are claimed to affect the expression of brain-derived neurotrophic factor (BDNF) and its receptor - tyrosine kinase B (TrkB) in the hippocampal regions differentially. This study aimed to explore the influence of chronic (15 min daily for 21 days) forced swim stress (FS) exposure on the BDNF and TrkB containing neurons in the hippocampal CA1, CA3 pyramidal cell layers and dentate gyrus (DG) granule cell layer in juvenile (P28) and aged (P360) rats. An immunofluorescence (-ir) method was used to detect BDNF-ir and TrkB-ir cells. Under chronic FS exposure, in the group of juvenile rats a significant decrease in the density of BDNF immunoreactive neurons was observed in CA1 and DG (p<0.001), unlike CA3, where it remained unaltered just as the density of TrkB-ir cells in CA1 and DG, but in CA3 the number of TrkB-ir cells was found to grow (p<0.05) in comparison with control groups. After chronic FS exposure of aged (P360) rats, the density of BDNF-ir and TrkB-ir cells did not decline in any of the subregions of the hippocampus. In all subfields of the hippocampus, the denseness of BDNF-positive neurons was significantly higher in P360 stressed group, compared with P28 stressed group, but the density of TrkB-ir fell more markedly in P360 than in P28. In conclusion, chronic FS stress influenced the number of BDNF and TrkB immunoreactive neurons only in juvenile animals. The age of rats tested in the chronic forced swim test was a decisive factor determining changes in the density of BDNF-ir and TrkB-ir in the hippocampal structures.
2

Developmental changes in the postnatal period-study of cholinergic innervation and parvabumin-positive neurons in the rat hippocampus

88%
Wojcik S., Ludkiewicz B., Spodnik E., Domaradzka-Pytel B., Morys J.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
3

Cholinergic innervation and calretinin-immunoreactive neurones in the hippocampus during postnatal development of the rat brain

88%
Ludkiewicz B., Wojcik S., Spodnik E., Domaradzka-Pytel B., Morys J.
Folia Morphologica
|
2002
|
tom 61
|
nr 1
7-14
Immunohistochemical study of the cholinergic innervation of the hippocampal calretinin-containing cells was conducted on 28 rat brains of postnatal ages: P0, P4, P7, P14, P21, P30 and P60. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and calretinin were analysed using confocal laser-scanning microscope. Obtained data demonstrate that during development as well as in adult species calretinin-containing neurones in the rat hippocampus form sparse synaptic contact with VAChT-ir terminals. It seems probable that cholinergic innervation is not crucial for the functioning of CR-ir cells — probably they remain under the greater influence of a system other than the cholinergic system.
4

Cholinergic innervation and calretinin-immunoreactive neurons in the hippocampus during postnatal development of the rat brain

88%
Spodnik E., Ludkiewicz B., Wojcik S., Domaradzka-Pytel B., Morys J.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
5

The influence of storage time upon the real thickness of the histological brain sections

88%
Dziewiatkowski J., Spodnik J. H., Wojcik S., Spodnik E., Morys J.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
6

Cholinergic endings on various neurones containing calcium binding proteins and glutamic acid decarboxylase in the hippocampus of the rat

88%
Ludkiewicz B., Wojcik S., Spodnik E., Domaradzka-Pytel B., Morys J.
Folia Morphologica
|
2000
|
tom 59
|
nr 4
Immunohistochemical study of the cholinergic innervation of the hippocampal cells containing glutamic acid decarboxylase (GAD) and calcium binding proteins: parvalbumin (PV), calbindin D28k (CB) and calretinin (CR) was conducted on 5 adult rat brains. Analysis of sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and respectively either GAD or PV, CB, CR, using confocal laser-scanning microscope shows that the intensive cholinergic innervations receive GAD, PV and CB-positive hippocampal cells. Cholinergic afferentations of the CR-positive neurones are considerably fewer.
7

Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain

76%
Ludkiewicz B., Wojcik S., Spodnik E., Domaradzka-Pytel B., Klejbor I., Morys J.
Folia Morphologica
|
2002
|
tom 61
|
nr 2
89-96
Immunohistochemical study of the cholinergic innervation of the parvalbuminand calbindin-containing cells in the hippocampus was conducted on 30 rat brains of various postnatal ages: P0, P4, P7, P14, P21, P30, P60 and P180. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and parvalbumin (PV) or calbindin (CB) were analysed using confocal laser-scanning microscope. Obtained data demonstrate that the pattern of cholinergic innervation of calbindin- and parvalbumin-immunoreactive hippocampal neurones shows some differences. During development as well as in the adult species cholinergic terminals preferentially innervate CB-containing neurones, while cholinergic terminals on PV-containing cells were observed rarely. Cholinergic endings on the CB-ir neurones are localised both on their somata and dendrites, whereas on PV-ir cells they form synaptic contact predominantly with processes. In spite of the unquestionable cholinergic influence particularly on CB-ir cells, the number of cholinergic endings suggests that this input seems not to be crucial for the activity of the studied cell populations.
8

Expression of the calcium-binding proteins in the central, medial and cortical nuclei of the rabbit amygdaloid complex during postnatal development

76%
Wojcik S., Luczynska A., Dziewiatkowski J., Spodnik E., Ludkiewicz B., Morys J.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr 2
Calbindin-D28k (CB), parvalbumin (PV) and calretinin (CR) are calcium-binding proteins (CaBPs) considered to be markers for certain subpopulations of neurons in the central nervous system. The aim of this study was to describe the pattern of distribution of CB-, PV- and CR-immunoreactive elements in the rabbit corticomedial amygdaloid complex during the postnatal period. The time course of changes in CaBPs expression during maturation of the selected nuclei indicates their diversity. During the first month after birth, CaBPs expression stabilizes earliest in the anterior cortical and then in the medial nuclei. Later, during the second month of postnatal life, the posteromedial and posterolateral cortical nuclei maturate. The central nucleus requires a considerably longer time to reach maturity - about three months are needed to stabilize CaBPs expression in all its subdivisions. This nucleus also shows the most differentiated, time-dependent distribution of CaBPs- immunoreactivity (especially CB), distinct in its divisions. The differences in the CaBPs immunoreactivity confirm previous reports concerning dissimilar origin and development, and also reflect the diversity of connectivity of the amygdaloid body - the collection of nuclei, considered as one functional integrity.
9

Relation between the age of specimen and the shrinkage of brain frozen sections

76%
Dziewiatkowski J., Wojcik S., Spodnik J. H., Spodnik E., Kowianski P., Morys J.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
10

Analysis of calcium binding protein immunoreactivity in the claustrum and the endopiriform nucleus of the rabbit

76%
Wojcik S., Dziewiatkowski J., Spodnik E., Ludkiewicz B., Domaradzka-Pytel B., Kowianski P., Morys J.
Acta Neurobiologiae Experimentalis
|
2004
|
tom 64
|
nr 4
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