A group of 173 obese men with asymptomatic hyperuricaemia or gout was observed. 123 of them were treated with low-purine low-calorie diet (LPLCD) in a hospital ward for 21 days. 50 patients (a control group) were put on an ordinary low-caloric diet (LCD). The results showed the evident hypouricaemic effect of LPLCD, The serum uric acid decreased by 25% in patients with asymptomatic hyperuricaemia and by 18% in the gouty patients. Body mass and serum lipids concentration were also significantly reduced. The nitrogen balance, negative at the beginning of the diet, was normalized at the end of treatment. LPLCD is recommended as a principal method in treatment of purine metabolism disturbances in obese hyperlipaemic patients.