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1

Białaczka ostrej fazy w przebiegu ostrego zapalenia trzustki

100%
Panek J., Kusnierz-Cabala B., Kapusta M., Naskalski J. W.
Diagnostyka Laboratoryjna
|
2001
|
tom 37
|
nr 1
2

Jaka jest przydatność diagnostyczna oznaczeń prokalcytoniny u chorych z podejrzeniem ostrego zapalenia wyrostka robaczkowego?

100%
Kusnierz-Cabala B., Anielski R., Szafraniec K., Solnica B.
Diagnostyka Laboratoryjna
|
2009
|
tom 45
|
nr 3
3
Content available remote

Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and STNFR55-TNFR75 in plasma of patients with acute pancreatitis

100%
Naskalski J. W., Kusnierz-Cabala B., Panek J., Kedra B.
Journal of Physiology and Pharmacology
|
2003
|
tom 54
|
nr 3
Plasma pancreatic-type Poly-C specific ribonuclease (P-RNase) - enzyme activity increases in patients with acute pancreatitis (AP) who develop pancreatic necrosis and severe disease course. It is considered as a marker of pancreatic tissue destruction. The aim of this study was to estimate interrelations between major inflammatory cytokines such as: interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor soluble receptors: sTNFR55 and sTNFR75 output, and plasma P-RNase activity. The study was carried out in a group of 56 patients with AP, where 20 developed pancreatic necrosis. It was found that serum P-RNase concentration and levels of all studied inflammatory cytokines significantly increase already in the first day from diagnose of the disease (2,5 folds for P-RNase, 20 for IL-8, about 200 for IL-6 and 1,5 for receptors, respectively). In the first day from admission to hospital, P-RNase activity significantly correlated with plasma concentration of studied inflammatory cytokines. The most pronounced correlation was found for P-RNase and IL-6 in days 1-4 from diagnose, manifested by Pearson correlation r coefficients amounting to 0,86; 0,79; 0,60 and 0,57 respectively (p<0,001). Dividing the studied AP patients into two groups, varying in severity of disease a significant differences in P-RNase and IL-6, IL-8 and sTNFR55/sTNFR75 were found. In patients with acute necrotizing pancreatitis P-RNase significantly correlate with levels of major inflammatory cytokines. Carried out studies suggest that activity of P-RNase reflects severity of inflammatory reaction, which is dependent on development of pancreatic injury and tissue necrosis in AP.
4

Przygotowanie pacjenta do badań laboratoryjnych

88%
Kapusta M., Kusnierz-Cabala B., Dumnicka P., Mazur A., Gernand W.
Diagnostyka Laboratoryjna
|
2007
|
tom 43
|
nr 3
5

Delta check

88%
Gernand W., Mazur A., Kusnierz-Cabala B., Kapusta M., Dumnicka P.
Diagnostyka Laboratoryjna
|
2007
|
tom 43
|
nr 3
6

Rola właściwego pobrania krwi

88%
Dumnicka P., Gernand W., Kapusta M., Kusnierz-Cabala B., Mazur A.
Diagnostyka Laboratoryjna
|
2007
|
tom 43
|
nr 3
7

Spójność wyników badań laboratoryjnych

88%
Kusnierz-Cabala B., Kapusta M., Dumnicka P., Mazur A., Gernand W.
Diagnostyka Laboratoryjna
|
2007
|
tom 43
|
nr 3
8

Znaczenie diagnostyczne zmian stężenia wapnia u chorych z ostrym zapaleniem trzustki

76%
Kusnierz-Cabala B., Fedak D., Gurda-Duda A., Solnica B., Dumnicka P., Panek J., Kulig J.
Diagnostyka Laboratoryjna
|
2010
|
tom 46
|
nr 3
9

Użyteczność lipokaliny zwiazanej z żelatynazą neutrofilów (NGAL) i wyliczanego wskaźnika NGAL do kreatyniny w moczu jako wczesnych predyktorów uszkodzenia nerek u pacjentów z cukrzycą typu 2

76%
Gala-Bladzinska A., Zylka A., Rybak K., Dumnicka P., Kuzniewski M., Kusnierz-Cabala B.
Diagnostyka Laboratoryjna
|
2015
|
tom 51
|
nr 2
10
Content available remote

Administration of warfarin accelerates the recovery in ischemia/reperfusion-induced acute pancreatitis

76%
Maduzia D., Ceranowicz P., Cieszkowski J., Chmura A., Galazka K., Kusnierz-Cabala B., Warzecha Z.
Journal of Physiology and Pharmacology
|
2020
|
tom 71
|
nr 3
11
Content available remote

Pretreatment with obestatin inhibits the development of cerulein-induced pancreatitis

64%
Ceranowicz P., Warzecha Z., Dembinski A., Cieszkowski J., Dembinski M., Sendur R., Kusnierz-Cabala B., Tomaszewska R., Kuwahara A., Kato I.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 3
95-101
Obestatin is a peptide derived from the proghrelin, a common prohormone for ghrelin and obestatin. Obestatin, like the ghrelin has been originally extracted from rat stomach, and the stomach seems to be a major source of circulating obestatin. Previous studies have shown that administration of ghrelin exhibits protective effect in the pancreas, inhibiting the development of acute pancreatitis. Recent study has shown that obestatin promotes survival of ß-cells and pancreatic islets. Aim of the present study was to investigate the influence of obestatin administration on the development of cerulein-induced pancreatitis. Studies were performed on male Wistar rats. Acute pancreatitis was induced by cerulein given intraperitoneally 5 times at a dose of 50 µg/kg/dose with 1-h intervals. Obestatin was injected twice intraperitoneally at the dose of 4, 8 or 16 nmol/kg/dose. In control saline-treated rats, obestatin was without effect on pancreatic morphology, serum activity of pancreatic enzymes, serum level of pro-inflammatory interleukin-1b or pancreatic cells proliferation. In animals with induction of acute pancreatitis, morphological examination showed that administration of obestatin decreased pancreatic leukocyte infiltration and vacuolization of acinar cells. These effects were accompanied by reduction in the pancreatitis-evoked increase in serum level of pancreatic digestive enzymes, lipase amylase and poly-C ribonuclease. Obestatin administered at the highest dose of 16 nmo/kg/dose reduced serum activity of these enzymes by 33, 42 and 44%, respectively. Also serum concentration of pro-inflammatory interleukin-1ß was decreased by obestatin in rats with acute pancreatitis; whereas the pancreatitis-evoked decrease in pancreatic blood flow and pancreatic DNA synthesis was partially reversed. Administration of obestatin reduces the severity of cerulein-induced acute pancreatitis. This effect is related, at least in part, to the improvement of pancreatic blood flow and reduction in pro-inflammatory interleukin-1ß release.
12
Content available remote

Role of hormonal axis, growth hormone - IGF-1, in therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis

64%
Ceranowicz D., Warzecha Z., Debinski A., Ceranowicz P., Cieszkowski J., Kusnierz-Cabala B., Tomaszewska R., Kuwahara A., Kato I.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 5
13
Content available remote

Protective and therapeutic effect of heparin in acute pancreatitis

64%
Ceranowicz P., Dembinski A., Warzecha Z., Dembinski M., Cieszkowski J., Rembiasz K., Konturek S. J., Kusnierz-Cabala B., Tomaszewska R., Pawlik W. W.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 4
103-125
14
Content available remote

Pretreatment with low doses of acenocoumarol inhibits the development of acute ischemia/reperfusion-induced pancreatitis

64%
Warzecha Z., Sendur P., Ceranowicz P., Dembinski M., Cieszkowski J., Kusnierz-Cabala B., Tomaszewska R., Dembinski A.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 5
15

Znaczenie białka śladowego beta (BTP) w ocenie uszkodzenia nerek we wczesnej fazie ostrego zapalenia trzustki

64%
Kusnierz-Cabala B., Dumnicka P., Mazur-Laskowska M., Sporek M., Wajda J., Ceranowicz P., Kuzniewski M., Gala-Bladzinska A., Maziarz B., Solnica B.
Diagnostyka Laboratoryjna
|
2017
|
tom 53
|
nr 1A
16
Content available remote

Therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis in rats

64%
Warzecha Z., Ceranowicz P., Dembinski A., Cieszkowski J., Kusnierz-Cabala B., Tomaszewska R., Kuwahara A., Kato I.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 4
419-427
Recent studies have shown that pretreatment with ghrelin exhibits protective effect in the gut. Administration of ghrelin reduces gastric mucosal damage, as well as inhibits the development of experimental pancreatitis. However, this protective effect requires administration of ghrelin before gastric or pancreatic damage and thus has a limited clinical value. The aim of present study was to assess the influence of ghrelin administered after development of acute pancreatitis on the course of this disease. Acute pancreatitis was induced by cerulein. Ghrelin was administered twice a day for 1, 2, 4, 6 or 9 days at the dose of 4, 8 or 16 nmol/kg/dose. The first dose of ghrelin was given 24 hours after last injection of cerulein. The severity of acute pancreatitis was assessed between 0 h and 10 days after cessation of cerulein administration. Administration of caerulein led to the development of acute edematous pancreatitis and maximal severity of this disease was observed 24 hours after induction of pancreatitis. Treatment with ghrelin reduced morphological signs of pancreatic damage such as pancreatic edema, leukocyte infiltration and vacuolization of acinar cells, and led to earlier regeneration of the pancreas. Also biochemical indexes of the severity of acute pancreatitis, serum activity of lipase and amylase were significantly reduced in animals treated with ghrelin. These effects were accompanied by an increase in the pancreatic DNA synthesis and a decrease in serum level of pro-inflammatory interleukin-1ß. Administration of ghrelin improved pancreatic blood flow in rats with acute pancreatitis. We conclude that: (1) treatment with ghrelin exhibits therapeutic effect in caerulein-induced experimental acute pancreatitis; (2) this effect is related, at least in part, to the improvement of pancreatic blood flow, reduction in proinflammatory interleukin-1b and stimulation of pancreatic cell proliferation.
17

Wartość prognostyczna oznaczeń szerokości rozkładu objętości erytrocytów u chorych w 5. stadium przewlekłej choroby nerek leczonych hemodializami

64%
Chmial E., Kusnierz-Cabala B., Gala-Bladzinska A., Dumnicka P., Mazur-Laskowska M., Kuzniewski M., Kucharz J., Maziarz B., Solnica B.
Diagnostyka Laboratoryjna
|
2017
|
tom 53
|
nr 1
18
Content available remote

Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia-reperfusion in rats; possible implication of tissue antioxidants

64%
Dembinski A., Warzecha Z., Konturek S. J., Ceranowicz P., Dembinski M., Pawlik W. W., Kusnierz-Cabala B., Naskalski J. W.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 4
Grapefruit seed extract (GSE) has been shown to exert antibacterial, antifungal and antioxidant activity possibly due to the presence of naringenin, the flavonoid with cytoprotective action on the gastric mucosa. No study so far has been undertaken to determine whether this GSE is also capable of preventing acute pancreatic damage induced by ischemia/reperfusion (I/R), which is known to result from reduction of anti-oxidative capability of pancreatic tissue, and whether its possible preventive effect involves an antioxidative action of this biocomponent. In this study carried out on rats with acute hemorrhagic pancreatitis induced by 30 min partial pancreatic ischemia followed by 6 h of reperfusion, the GSE or vehicle (vegetable glycerin) was applied intragastrically in gradually increasing amounts (50-500 µl) 30 min before I/R. Pretreatment with GSE decreased the extent of pancreatitis with maximal protective effect of GSE at the dose 250 µl. GSE reduced the pancreatitis-evoked increase in serum lipase and poly-C specific ribonuclease activity, and attenuated the marked fall in pancreatic blood flow and pancreatic DNA synthesis. GSE administered alone increased significantly pancreatic tissue content of lipid peroxidation products, malondialdehyde and 4-hydroxyalkens, and when administered before I/R, GSE reduced the pancreatitis-induced lipid peroxidation. We conclude that GSE exerts protective activity against I/R-induced pancreatitis probably due to the activation of antioxidative mechanisms in the pancreas and the improvement of pancreatic blood flow.
19
Content available remote

Ischemic preconditioning of the hindlimb or kidney does not attenuate the severity of acute ischemia-reperfusion-induced pancreatitis in rats

64%
Warzecha Z., Dembinski A., Ceranowicz P., Cieszkowski J., Konturek S. J., Dembinski M., Kusnierz-Cabala B., Tomaszewska R., Pawlik W. W.
Journal of Physiology and Pharmacology
|
2008
|
tom 59
|
nr 2
Ischemic preconditioning of several organs, including the pancreas has been shown to protect these organs from injury evoked by subsequent exposure to severe ischemia followed by reperfusion. Moreover, it has been shown that ischemic preconditioning of distant organs such as the kidney, intestine or limb may protect the heart as effectively as cardiac preconditioning itself. This study was designed to determine whether ischemic preconditioning of the kidney or hindlimb protects the pancreas against ischemia/reperfusion-induced pancreatitis. Methods: In male Wistar rats, remote ischemic preconditioning of the pancreas was performed by clamping of right femoral or renal artery twice for 5 min with 5 min interval. Direct ischemic preconditioning was performed by clamping of celiac artery. Thirty min after ischemic preconditioning or sham-operation, acute pancreatitis was induced by clamping of inferior splenic artery for 30 min followed by reperfusion. After 6, 12 h or 1, 2, 3, 5 or 9 days of reperfusion the experiment was ended. Secretory studies were performed 2 h after exposure to direct or remote ischemic preconditioning of the pancreas in conscious rats with chronic pancreatic fistula. Results: Direct ischemic preconditioning of the pancreas applied alone reduced pancreatic exocrine secretion; whereas ischemic preconditioning of the hindlimb or kidney was without effect on pancreatic secretion. Direct ischemic preconditioning of the pancreas attenuated the severity of acute pancreatitis. It was found as a reduction in the pancreatitis-evoked increase in serum activity of lipase and amylase, a decrease in serum concentration of pro-inflammatory interleukin-1ß, diminution of histological signs of pancreatic damage, as well as, an improvement of pancreatic blood flow and DNA synthesis. Remote ischemic preconditioning of the pancreas evoked by short-lasting ischemia of the hindlimb or kidney was without any protective effect in ischemia/reperfusion-induced pancreatitis. Moreover, this procedure led to a significant increase in serum activity of lipase and amylase, and enhanced the morphological signs of pancreatic damage. Conclusion: In contrast to direct ischemic preconditioning, remote ischemic preconditioning of the pancreas is without effect on pancreatic exocrine secretion and does not reduce the severity of ischemia/reperfusion-induced pancreatitis.
20
Content available remote

Therapeutic effect of exogenous ghrelin in the healing of gingival ulcers is mediated by the release of endogenous growth hormone and insulin-like growth factor-1

52%
Cieszkowski J., Warzecha Z., Ceranowicz P., Ceranowicz D., Kusnierz-Cabala B., Pedziwiatr M., Dembinski M., Ambrozy T., Kaczmarzyk T., Pihut M., Wieckiewicz M., Olszanecki R., Dembinski A.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 4
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