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Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes

100%

Nikkhahi M., Souri E., Sarkhail P., Baeeri M., Mohammadhosseini N.

Acta Scientiarum Polonorum. Technologia Alimentaria

2018

tom 17

nr 3

On the benefit of whey-cultured Lactobacillus casei in murine colitis

72%

Ghasemi-Niri S. F., Abdolghaffari A. H., Fallah-Benakohal S., Hosseinpour-Feizi M., Mahdaviani P., Jamalifar H., Baeeri M., Dehghan D., Abdollahi M.

Journal of Physiology and Pharmacology

2011

tom 62

nr 3

The objective of this study was to examine the prophylactic and therapeutic effect of whey-cultured Lactobacillus casei (L. casei) in a murine model of colitis. Colitis was induced by intracolonic administration of a mixture of 2,4,6-trinitrobenzenesulphonic acid (TNBS)/absolute ethanol in male Wistar rats. Animals were divided into 5 groups including sham (normal group), control (vehicle-treated), positive control (dexamethasone 1 mg/kg/day, orally), prevention (108 cfu L. casei/day, orally, 14 days before induction of colitis), and treatment (108 cfu L. casei/day, orally, 14 days after induction of colitis). After 14-days treatment, the animals were sacrificed on the day 15. Distal colons were removed for examining histological and biochemical assays. Biomarkers including TNF-, myeloperoxidase (MPO), and lipid peroxidation (LPO) were measured in the homogenate of colon. Results indicated an apparent improvement in colon histopathology scores, TNF-, MPO, and LPO in the treatment group, whereas prevention group did not demonstrate positive efficacy in prevention of colonic damage. It is concluded that L. casei grown in whey culture is very effective in ameliorating both biochemical and histopathological markers of colitis if used post induction of colitis but not if used before induction of colitis. The difference between effects of L. casei when used pre-colitis and post-colitis confirms its mechanism of action as an anti toxic stress agent. Further studies should be made in IBD patients.

Ograniczanie wyników

1 Acta Scientiarum Polonorum. Technologia Alimentaria

1 Journal of Physiology and Pharmacology

2 Baeeri M.

1 Abdolghaffari A. H.

1 Abdollahi M.

1 Dehghan D.

1 Fallah-Benakohal S.

1 Ghasemi-Niri S. F.

1 Hosseinpour-Feizi M.

1 Jamalifar H.

1 Mahdaviani P.

1 Mohammadhosseini N.

1 Nikkhahi M.

1 Sarkhail P.

1 Souri E.

1 2018

1 2011

Wyniki wyszukiwania

Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes

On the benefit of whey-cultured Lactobacillus casei in murine colitis