Wyniki wyszukiwania

1

Mutagenic activity of radiosensitizers

100%

Grzybowska E., Kalinowska E., Szala S.

Acta Microbiologica Polonica

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1985

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tom 34

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nr 2

2

Analysis of the posttranscriptional regulation of DNA polymerase beta expression in the rat cells

100%

Grzybowska E., Wilczynska A., Sarnowska E., Siedlecki J.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

3

Sekwencjonowanie genomu drozdzy Saccharomyces cerevisiae. Cele, strategie, rezultaty

100%

Grzybowska E., Migdalski A., Zagulski M.

Postępy Biochemii

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1993

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tom 39

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nr 3

156-164

4

DNA adducts in environmental, occupational and life-style studies in human biomonitoring

100%

Hemminki K., Grzybowska E., Widlak P., Chorazy M.

Acta Biochimica Polonica

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1996

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tom 43

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nr 2

The importance of DNA adducts in carcinogenesis has been discussed. The 32P-postlabelling method was developed as a quantitative technique to measure the level of different DNA adducts including adducts in human DNA. The elevated level of DNA adducts was found in white blood cells in persons exposed environmentally and occupationally to high concentrations of PAHs (polycyclic aromatic hydrocarbons) in the ambient air. Tobacco also generated higher level of DNA adducts both in lymphocytes and laryngeal tissues of smokers. Exposure to styrene has been of interest world-wide because of the very high exposure and persistence of adducts in DNA of lamination workers.

5

The role of HAX-1 and MCPIP proteins in regulation of transcripts involved in pro-inflammatory response of cancer cells

64%

Macech-Klicka E., Sarnowska E., Rusetska N., Chrzan A., Ligaj M., Szymanski M., Demkow T., Grzybowska E., Siedlecki J. A.

Acta Biochimica Polonica

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2018

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tom 65

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nr S2

6

Sequence analysis of ATPase domain of heat shock cognate 70 gene in non-small cell lung carcinoma

64%

Zientek H., Rusin M., Lisowska K., Pawlas M., Sieminska M., Butkiewicz D., Grzybowska E., Krawczyk Z.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

7

Germline mutations in the BRCA1 gene predisposing to breast and ovarian cancers in Upper Silesia population

64%

Grzybowska E., Sieminska M., Zientek H., Kalinowska E., Michalska J., Utracka-Hutka B., Rogozinska-Szczepka J., Kazmierczak-Maciejewska M.

Acta Biochimica Polonica

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2002

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tom 49

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nr 2

Germline mutations in the BRCA1 or BRCA2 genes predispose their carriers to breast or/and ovary cancers during their lifetime. The most frequent mutations: 5382insC, 185delAG, C61G and 4153delA in BRCA1, and 6174delT and 9631delC in BRCA2 were studied in a group of 148 probands admitted for genetic counseling, using allele-specific amplification (ASA) PCR test. Fifteen carriers of three different mutations: 5382insC, 185delAG and C61G in BRCA1 were found. Two families carried the 185delAG mutation and additional two C61G in BRCA1. Nobody carried the mutation 4153delA in BRCA1 nor 6174delT or 9631delC in BRCA2. Most of the carriers of a germline mutation were observed among the patients who developed bilateral breast cancer (17%). The lowest frequency of the germline mutations was found in the healthy persons who had two or more relatives affected with breast or ovarian cancer.

8

BRCA1, BRCA2 and TP53 mutations in breast and ovarian cancer cases from Upper Silesia in Poland

51%

Zientek H., Jasinska A., Rusin M., Kozlowski P., Sobczak K., Sikorska A., Kwiatkowska E., Gorniak L., Kalinowska E., Rogozinska-Szczepka J., Utracka-Hutka B., Wloch J., Chmielik E., Sieminska M., Krzyzosiak W., Grzybowska E.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

9

Prevalence of the most frequent BRCA1 mutations in Polish population

39%

Brozek I., Cybulska C., Ratajska M., Piatkowska M., Kluska A., Balabas A., Dabrowska M., Nowakowska D., Niwinska A., Pamula-Pilat J., Tecza K., Pekala W., Rembowska J., Nowicka K., Mosor M., Januszkiewicz-Lewandowska D., Rachtan J., Grzybowska E., Nowak J., Steffen J., Limon J.

Journal of Applied Genetics

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2011

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tom 52

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nr 3

The purpose of our study was to establish the frequency and distribution of the four most common BRCA1 mutations in Polish general population and in a series of breast cancer patients. Analysis of the population frequency of 5382insC (c.5266dupC), 300T >G (p.181T >G), 185delAG (c.68_69delAG) and 3819del5 (c.3700_3704del5) mutations of the BRCA1 gene were performed on a group of respectively 16,849, 13,462, 12,485 and 3923 anonymous samples collected at birth in seven Polish provinces. The patient group consisted of 1845 consecutive female breast cancer cases. The most frequent BRCA1 mutation in the general population was 5382insC found in 29 out of 16,849 samples (0.17%). 300T >G and 3819del5 mutations were found in respectively 11 of 13,462 (0.08%) and four of 3923 (0.1%) samples. The population prevalence for combined Polish founder 5382insC and 300T >G mutations was 0.25% (1/400). The frequencies of 5382insC and 300T >G carriers among consecutive breast cancer cases were, respectively, 1.9% (35/1845) and 1.2% (18/1486). Comparing these data with the population frequency, we calculated the relative risk of breast cancer for 5382insC mutation at OR = 17 and for 300T >G mutation at OR = 26. Our results, based on large population studies, show high frequencies of founder 5382insC and 300T >G BRCA1 mutations in Polish general population. Carriage of one of these mutations is connected with a very high relative risk of breast cancer.

Ograniczanie wyników

Mutagenic activity of radiosensitizers

Analysis of the posttranscriptional regulation of DNA polymerase beta expression in the rat cells

Sekwencjonowanie genomu drozdzy Saccharomyces cerevisiae. Cele, strategie, rezultaty

DNA adducts in environmental, occupational and life-style studies in human biomonitoring

The role of HAX-1 and MCPIP proteins in regulation of transcripts involved in pro-inflammatory response of cancer cells

Sequence analysis of ATPase domain of heat shock cognate 70 gene in non-small cell lung carcinoma

Germline mutations in the BRCA1 gene predisposing to breast and ovarian cancers in Upper Silesia population

BRCA1, BRCA2 and TP53 mutations in breast and ovarian cancer cases from Upper Silesia in Poland

Prevalence of the most frequent BRCA1 mutations in Polish population