Wyniki wyszukiwania

1

Correction to: Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing

100%

Lee J. W., Shin J.-Y., Seo J.-S.

Journal of Applied Genetics

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2018

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tom 59

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nr 3

2

Carbon emission allowances of efficiency analysis: application of super SBM ZSG-DEA model

100%

Chiu Y.-h., Lin J.-C., Hsu C.-C., Lee J. W.

Polish Journal of Environmental Studies

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2013

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tom 22

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nr 3

Our study analyzes the emission allowances of 24 European Union (EU) members from a sample taken from 2005-07. A Super Slacks-Based Measure Zero Sum Gains Data Envelopment Analysis (Super SBM-ZSG-DEA) model was employed to examine allocation equality. The empirical results indicated that the countries with higher efficiency would have to increase their emission allowances. The majority of investigated countries with lower rankings in the initial allowances were likely to be less developed countries. Accordingly, these less developed countries would have to decrease their emission allowances in order to be more realistic and compliant regarding allowance allocations.

3

Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing

100%

Lee J. W., Shin J.-Y., Seo J.-S.

Journal of Applied Genetics

|

2018

|

tom 59

|

nr 3

4

Spironolactone, but not enalapril, potentiates hypoxia-inducible factor-1alpha and Ets-1 expression in newborn rat kidney

76%

Yim H. E., Kim J. H., Yoo K. H., Bae I. S., Jang G. Y., Hong Y. S., Lee J. W.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 1

73-81

Hypoxia is regarded as an important physiological factor that controls nephrogenesis. We investigated whether the renin-angiotensin-aldosterone system (RAAS) affects hypoxia-related target genes in developing kidneys. Newborn rat pups were treated with enalapril (30 mg/kg/d) or spironolactone (200 mg/kg/d) for 7 days. Tissue hypoxia was assessed by the uptake of a hypoxyprobe-1, pimonidazole (200 mg/kg), and the expression of hypoxia-responsive genes. In the enalapril group, hypoxia-inducible factor (HIF)-1, HIF-2, and Ets-1 protein expression were not changed, compared to the control group. In the spironolactone group, HIF-1 and Ets-1 protein expression were significantly increased by immunoblots and immunohistochemistry, whereas HIF-2 protein expression was not changed, compared to the control group. In the enalapril group, the immunoactivity of pimonidazole was not significantly different from that of the controls. However, in the spironolactone group, pimonidazole staining demonstrated that the cortex and medulla underwent severe hypoxia. In summary, our data showed that aldosterone inhibition in the developing kidney augmented the hypoxic responses, and up-regulated the expression of key mediators of hypoxia including HIF-1 and Ets-1. Angiotensin II inhibition did not affect hypoxia-related alterations in the developing kidney. The components of RAAS may differentially modulate renal hypoxia and its related target genes in the developing rat kidney.

Ograniczanie wyników

2 Journal of Applied Genetics

1 Journal of Physiology and Pharmacology

1 Polish Journal of Environmental Studies

4 Lee J. W.

2 Seo J.-S.

2 Shin J.-Y.

1 Bae I. S.

1 Chiu Y.-h.

1 Hong Y. S.

1 Hsu C.-C.

1 Jang G. Y.

1 Kim J. H.

1 Lin J.-C.

1 Yim H. E.

1 Yoo K. H.

2 2018

1 2013

1 2010

Correction to: Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing

Carbon emission allowances of efficiency analysis: application of super SBM ZSG-DEA model

Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing

Spironolactone, but not enalapril, potentiates hypoxia-inducible factor-1alpha and Ets-1 expression in newborn rat kidney