Central serotonin 2C receptors (5-HT2CR) are known to modulate the mesoaccumbens dopamine (DA) pathway by controlling DA release in the nucleus accumbens (NAc) and DA neuronal firing in the ventral tegmental area. Studies assessing the influence of 5-HT2CRs agonists on cocaine-induced responses, have suggested that 5-HT2CRs can also modulate mesoaccumbens DA pathway activity independently of DA release, thereby controlling NAc DA transmission. In the present study we assessed this hypothesis by studying the influence of the 5-HT2CR agonist Ro60-0175 on cocaine-induced behavioral, neurochemical and immunohistochemical responses. The intraperitoneal administration of 1 mg/kg Ro60-0175 had no effect on the increase in NAc shell DA outflow induced by 15 mg/kg cocaine. Conversely, Ro60-0175 inhibited the hyperlocomotion induced by cocaine or by the DA-D2R agonist quimpirole (1 mg/kg), as well as cocaine-induced increase in FOS-like immunoreactivity in the NAc. These findings, considering the tight relationship between locomotor activity and NAc DA function, demonstrate that 5-HT2CR stimulation can modulate mesoaccumbens DA pathway independently of changes of NAc DA release, thereby controlling DA transmission in the NAc.
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.