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1

Trawienie białek, wchłanianie aminokwasów

100%
Tyszka-Czochara M.
Dietetyka. Oficjalne Czasopismo Polskiego Towarzystwa Dietetyki
|
2007
|
tom 01
|
nr 1
2

Effect of selected polyphenols on liver pyruvate dehydrogenase kinase (PDK) activity in rats

100%
Tyszka-Czochara M.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
3
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Recent advances in the role of AMP-activated protein kinase in metabolic reprogramming of metastatic cancer cells: targeting cellular bioenergetics and biosynthetic pathways for anti-tumor treatment

51%
Tyszka-Czochara M., Konieczny P., Majka M.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 3
4

Effect of fibrates on branched-chain alpha-ketoacid dehydrogenase complex activity

51%
Knapik-Czajka M., Tyszka-Czochara M., Jaskiewicz J.
Acta Toxicologica
|
2003
|
tom 11
|
nr 2
5

Effect of fibrates on the branched-chain alpha-ketoacid dehydrogenase complex in rat liver

45%
Knapik-Czajka M., Cyganek I., Tyszka-Czochara M., Francik R., Jaskiewicz J.
Acta Poloniae Toxicologica
|
2002
|
tom 10
|
nr 2
6

Effect selected fibrates on liver branched-chain alpha-ketoacid dehydrogenase complex

45%
Knapik-Czajka M., Jaskiewicz J., Cyganek I., Tyszka-Czochara M., Francik R.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
7

Antihistaminic activity of lidocaine derivatives in the isolated guinea pig ileum

39%
Librowski T., Pytka K., Salat K., Rapacz A., Moniczewski A., Gdula-Argasinska J., Tyszka-Czochara M.
Acta Biologica Cracoviensia. Series Zoologia
|
2012
|
tom 54
Local anesthetics (LAs) are drugs that inhibit membrane depolarization by reducing sodium conductance. In addition to the most prominent and well-defined function of LAs described above, numerous studies have shown that LAs possess many other properties, such as anti-inflammatory, anti-arrhythmic or analgesic activities. Furthermore, LAs are structurally similar to histamine H-receptor antagonists. Thus, LAs can be considered antihistaminic drugs. The aim of the present study was to determine and compare the antihistaminic effects of lidocaine derivatives - JCB-1, JCB-2 and JCB-3 - on the isolated guinea pig ileum. Only JCB-1 and JCB-2 at the highest concentration (10 4M) showed the antihistaminic effect. The studied compounds showed a dose-dependent effect. Interestingly, lower concentrations of the studied compounds (10 8M and 10"I0M) caused the opposite effect - increased the contraction of the ileum induced by histamine. These effects necessitate further studies. Nevertheless, this is the first time that JCB compounds have been demonstrated to possess antihistaminic properties.
8

Animal models for hypertension research

39%
Razny K., Bednarski M., Sapa J., Gdula-Argasinska J., Tyszka-Czochara M., Librowski T., Salat K.
Acta Biologica Cracoviensia. Series Zoologia
|
2013-2014
|
tom 55-56
9

Identification of lipid derivatives in Hep G2 cells

39%
Gdula-Argasinska J., Gabracik A., Tyszka-Czochara M., Wozniakiewicz M., Pasko P., Czepiel J.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 4
Metabolism of polyunsaturated fatty acids results in biosynthesis of mediators with different physiological effects. These metabolites include prostaglandins, prostacyclins, isoprostanes and others that are important signalling molecules and regulate a variety of physiological and pathophysiological processes including inflammation. Prostaglandins and isoprostanes are produced by either non-enzymatic lipid peroxidation or by enzyme-induced peroxidation (cyclooxygenases and lipoxygenases). They are used as biomarkers of oxidative stress. The aim of our study was to assess the effect of eicosapentaenoic acid (EPA) supplementation with added benzo(a)pyrene (BaP) on HepG2 cells by using a UHPLC/MS-TOF method. This rapid and simple method was developed for the identification, separation and quantification of 8-iPGF3α, PGF3α, 8-isoPGF2α and 5-iPF2α in cultured cells. The UHPLC/MS-TOF method was validated. The calculated limit of detection was in the range of 0.16-0.50 ng/mL, precision (% RSD): 1.2-2.1% and recoveries better than 88%. This method empowered qualitative and quantitative analysis of the selected individual prostaglandins derived from arachidonic acid and eicosapentaenoic acid from cell extracts.
10

Porównanie aktywności antyoksydacyjnej i całkowitej zawartości polifenoli w kiełkach i różyczkach brokułów

39%
Pasko P., Prochownik E., Galanty A., Barton H., Tyszka-Czochara M., Zagrodzki P., Zachwieja Z.
Bromatologia i Chemia Toksykologiczna
|
2018
|
tom 51
|
nr 2
11

Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level

39%
Grzywacz A., Gdula-Argasinska J., Muszynska B., Tyszka-Czochara M., Librowski T., Opoka W.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 3
12

Differential effects of zinc supplementation on the anti-inflammatory activity of ketoprofen in rats

33%
Lipkowska A., Gawel M., Olbert M., Gdula-Argasinska J., Tyszka-Czochara M., Rij E., Rak A., Razny K., Salat K., Librowski T.
Acta Biologica Cracoviensia. Series Zoologia
|
2013-2014
|
tom 55-56
13

Cytotoxic effects of alpha-lipoic acid and its biodegradation derivatives - a comparative study in an in vitro model of murine embryo fibroblasts

33%
Tyszka-Czochara M., Dudek M., Rak A., Salat K., Gluch-Lutwin M., Bilska-Wilkosz A., Kwiecien I., Pasko P., Gdula-Argasinska J., Librowski T.
Acta Biologica Cracoviensia. Series Zoologia
|
2013-2014
|
tom 55-56
14

Influence of gamma-butyrolactone derivatives with analgesic properties on the prostaglandin E2 level and gastric mucosa in rodents

27%
Salat K., Librowski T., Gdula-Argasinska J., Tyszka-Czochara M., Jastrzebska-Wiesek M., Moniczewski A., Rapacz A., Pytka K., Filipek B., Wieckowski K., Malawska B.
Acta Biologica Cracoviensia. Series Zoologia
|
2012
|
tom 54
Our recent studies indicate that some derivatives of gamma-butyrolactone (GBL) possess analgesic properties in rodent models of pain and inflammation. Despite this pronounced biological activity, the mechanism of action of these GBL still remains unclear. Searching for the plausible mechanism of their action we investigated whether they were (similarly to nonsteroidal anti-inflammatoiy drugs) capable of influencing the PGE2 level in mice subjected experimentally to zymosan-induced peritonitis. The PGE2 level was evaluated in vitro by means of the ELISA assay. We also investigated the influence of orally administered GBL on the rat gastric mucosa in post mortem studies. We have demonstrated that neither of the GBL derivatives influences the PGE2 level in zymosan-induced inflammation of the peritoneal cavity in mice. The investigated compounds are also devoid of adverse effects within the stomach, typical of cyclooxygenase inhibitors, which also indirectly suggests that their analgesic and anti-inflammatory activities result from mechanisms other than cyclooxygenase inhibition.
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