Metabolic alterations in physiological aging may depend on oxidative-antioxidative balance and biomineral status. The aim was to analyze concentrations of serum copper (Cu) and zinc (Zn) among excess body mass persons due to their age. Material: 72 healthy Caucasians, divided into 3 groups: AGE1, AGE2, AGE3 (30-45, 46-60, 61-75 years old respectively), with body mass index (BMI) ≥25 kg m–2 were qualified for oral glucose tolerance test (OGTT) and fasting (G0') and 2-hours (G120') glycemia were determined (enzymatically). Type 2 diabetes mellitus was excluded. Concentration of serum Cu and Zn (AAS), insulin (ELISA) and plasma lipids: total cholesterol, high density lipoproteins cholesterol, triacyloglyceroles (enzymatically) were measured in fasting samples. Low density lipoproteins cholesterol was obtained using Friedewald formula. Insulin Resistance ratios and Cu/Zn ratio were calculated. Results: No differences concerning BMI, waist, diastolic blood pressure, lipids and insulin concentrations and insulin resistance ratios were observed. Increasing G0’, G120' and systolic blood pressure from group 1 to 3 (p=0.01, p=0.01, p=0.04 respectively) were found. AGE2 group had the lowest Zn concentration 10.67±3.37 μmol dm–3, (p=0.002) and the highest Cu/Zn ratio 1.73±0.64 (p=0.0003). We calculated negative correlations Zn and SBP (R=-0.45, p=0.04), Zn and DBP (R=-0.46, p=0.04), Zn and G 120’ (R=-0.45, p=0.03) in the oldest group. Conclusions: Different zinc concentration while aging may occur, and may imply different metabolic usage of the biominerals, especially in obese patients otherwise healthy subjects.
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.