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1

Thyroliberin (TRH) and release of vasopressin and oxytocin from the rat hypothalamo-neurohypophysial explants in vitro

100%
Ciosek J., Stempniak B.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 5
2

Intracerebroventricular insulin affects the neurohypophysial vasopressin content in euhydrated and dehydrated rats

100%
Stempniak B., Guzek J. W.
Acta Physiologica Polonica
|
1990
|
tom 41
|
nr 7
Stempniak В. and Guzek J. W.: Intracerebroventricular insulin affects the neurohypophysial vasopressin content in euhydrated and dehydrated rats. Acta Physiol. Pol., Rats euhydrated or dehydrated for four days were given intracerebroventricular insulin once daily in a dose of 100 ng (not affecting blood sugar level). In euhydrated rats, insulin decreased significantly the neurohypophysial vasopressin content. In dehydrated animals the neurohypophysial content depleted by deprivation of water could be further reduced by intracerebroventricular treatment with insulin. These results may suggest a possible regulatory role of brain insulin in the mechanisms of vasopressin release.
3

The effect of melatonin on suckling-induced oxytocin relase in the rat

100%
Juszczak M., Stempniak B.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 3
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The influence of vasopressin or oxytocin on thyroid-stimulating hormone and thyroid hormones' concentrations in blood plasma of euthyroid rats

100%
Ciosek J., Stempniak B.
Journal of Physiology and Pharmacology
|
1997
|
tom 48
|
nr 4
5
Content available remote

TGLP-1 and release of vasopressin and oxytocin from the isolated rat hypothalamo-neurohypophysial system: effects of a TGLP-1 receptor agonist and antagonist

100%
Bojanowska E., Stempniak B.
Journal of Physiology and Pharmacology
|
2001
|
tom 52
|
nr 4,2
To date, glucagon-like peptide–1 (7-36) amide (tGLP-1) has been found to enhance the vasopressin and oxytocin secretion in vivo but not in vitro (i.e., when the isolated neurointermediate lobe of the pituitary was used for experiments). The goal of this study was to investigate whether tGLP-1 can influence the function of the hypothalamo-neurohypophysial complex in vitro. Also, the effect of a tGLP-1 agonist, exendin-4, and antagonist, exendin-(9-39), on the release of vasopressin/oxytocin from the isolated rat hypothalamo-neurohypophysial complex was tested. tGLP-1 enhanced the basal but not the potassium-stimulated release of vasopressin and oxytocin from the hypothalamo-neurohypophysial complex. On the other hand, tGLP-1 failed to affect the release of both hormones from the isolated neurointermediate lobe. The tGLP-1 agonist increased the secretion of oxytocin and vasopressin from the hypothalamo-neurohypophysial system whilst the tGLP-1 antagonist completely abolished the stimulatory effect of tGLP-1 on the secretion of both hormones. It is concluded that tGLP-1 affects the function of vasopressin- and oxytocinergic neurones through specific hypothalamic receptors.
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Thyrotropin-releasing hormone [TRH] modifies oxytocin release from the hypothalamo-neurohypophysial system in salt-loaded rats

100%
Ciosek J., Stempniak B.
Journal of Physiology and Pharmacology
|
1995
|
tom 46
|
nr 2
7

Thyrotropin-releasing hormone [TRH] inhibits vasopressin and oxytocin release from rat hypothalamo-neurohypophysial explants in vitro

100%
Ciosek J., Stempniak B.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Insulin-like immunoreactivity [IRI] the rat hypothalamo-neurohypophysial system: effect of dehydration and haemorrhage

100%
Stempniak B., Guzek J. W.
Journal of Physiology and Pharmacology
|
1993
|
tom 44
|
nr 2
9

Tachykinins and the response of vasopressin to melatonin-in vitro study

81%
Juszczak M., Bojanowska E., Stempniak B.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
10

Neurokinin A and the oxitocin response to malatonin-in vitro studies

81%
Bojanowska E., Stempniak B., Juszczak M.
Acta Neurobiologiae Experimentalis
|
2001
|
tom 61
|
nr 3
11

Hypothalamic and neurohypophysial oxytocin and vasopressin content following haemorrhage in melatonin-treated male rat

81%
Juszczak M., Stempniak B., Klopotowska A.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 3
12
Content available remote

Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of gonadotrophin-releasing hormone [GnRH], its analogues and melatonin

81%
Boczek-Leszczyk E., Stempniak B., Juszczak M.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 4
459-466
The influence of gonadotrophin-releasing hormone (GnRH) and its analogues (i.e., agonist and antagonist) on vasopressin (VP) release from the rat hypothalamo-neurohypophysial (H-N) system was studied both in vitro and in vivo. Additionally, it was determined whether the possible response of vasopressinergic neurones to these peptides could be modified by melatonin through a cAMP-dependent mechanism. In this study we demonstrate, for the first time, that the highly selective GnRH agonist (i.e., [Des-Gly10,D-His(Bzl)6,Pro-NHEt9]-LHRH; histrelin) stimulates the release of VP from the rat H-N system, while native GnRH and its antagonist remain inactive in modifying this process in vitro. Melatonin significantly inhibited basal and histrelin-induced release of VP in vitro, but displayed no significant influence on VP secretion when GnRH or its antagonist were present in a medium. Melatonin fully suppressed forskolin-stimulated VP release from the rat H-N system. On the other hand, addition of forskolin to a medium containing both histrelin and melatonin did not further alter the inhibitory influence of melatonin on the histrelin-dependent release of VP in vitro. After intracerebroventricular (i.c.v.) infusion of native GnRH or its agonist, blood plasma VP concentration was significantly higher than in control animals, which was accompanied by decreased content of the hormone in the neurohypophysis. Intravenous (i.v.) injection of melatonin did not change, in any subgroup, blood plasma VP concentration, when compared to the vehicle-injected rats. However, the neurohypophysial levels of the hormone were significantly higher after melatonin injection in control, GnRH- and histrelin-infused animals. Our present results suggest that activation of the GnRH receptor in the hypothalamus is involved in stimulation of VP secretion from the rat H-N system. We have also shown that melatonin, at a concentration close to its physiological level in the blood, significantly reduces the in vitro response of vasopressinergic neurones to a GnRH agonist - histrelin; this effect of melatonin could be mediated through intracellular processes that involve, among others, the cAMP-dependent mechanism.
13

Thyroliberin (TRH) affects the oxytocin and prolactin release in female rats during midlactation

81%
Ciosek J., Guzek J. W., Stempniak B., Dabrowski R.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
14
Content available remote

The influence of melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies

81%
Juszczak M., Roszczyk M., Kowalczyk E., Stempniak B.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 6
15
Content available remote

Role of tachykinin receptors and melatonin in oxytocin secretion from isolated rat hypothalamo-neurohypophysial system

81%
Juszczak M., Furykiewicz-Nykis K., Stempniak B.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 4
Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system as well as to determine whether the tachykinin NK-1 and/or NK-2 receptors contribute to the response of oxytocinergic neurons to melatonin. The results show, for the first time, that highly selective NK-1 receptor agonist, i.e., [Sar9,Met(O2)11]-Substance P, enhances while the NK-1 receptor antagonist (Tyr6,D-Phe7,D-His9)-Substance P (6-11) - sendide - diminishes significantly OT secretion; the latter peptide was also found to antagonize the substance P-induced hormone release from isolated rat H-N system, when used at the concentration of 10-7 M/L. Melatonin significantly inhibited basal and substance P-stimulated OT secretion. Neurokinin A and the NK-2 receptor selective agonist (ß-Ala8)-Neurokinin A (4-10) as well as the NK-2 receptor antagonist (Tyr5,D-Trp6,8,9, Lys-NH210)-Neurokinin A (4-10) were essentially inactive in modifying OT release from the rat H-N system in vitro. The present data indicate a distinct role for tachykinin NK-1 (rather than NK-2) receptor in tachykinin-mediated regulation of OT secretion from the rat H-N system. Under present experimental conditions, however, a role of respective tachykinin receptors in the response of oxytocinergic neurons to melatonin has not been found.
16
Content available remote

Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies

81%
Juszczak M., Boczek-Leszczyk E., Stempniak B.
Journal of Physiology and Pharmacology
|
2007
|
tom 58
|
nr 4
The aim of the present study was to investigate the influence of melatonin on vasopressin (AVP) release from the rat hypothalamo-neurohypophysial (H-NH) system, both in vivo and in vitro, possibly modified by the peptide NK-1 and/or NK-2 receptor agonists and antagonists. Highly selective NK-1 receptor agonist, i.e., [Sar9,Met(O2)11]-Substance P, has been shown to enhance the AVP release from isolated rat H-NH system in vitro, while the NK-1 receptor antagonist - (Tyr6,D-Phe7,D-His9)-Substance P (6-11) as well as the NK-2 receptor selective agonist - (ß-Ala8)-Neurokinin A (4-10) and antagonist - (Tyr5,D-Trp6,8,9,Lys-NH210)-Neurokinin A (4-10) were essentially inactive in modifying AVP secretion. Melatonin inhibited basal release of AVP but was not able to reduce significantly the in vitro response of vasopressinergic neurones to NK-1 receptor agonist. After intracerebroventricular (icv) administration, substance P (SP), neurokinin A (NKA) and the NK-1 receptor agonist (all at the concentration of 10-7 M/L) significantly enhanced plasma AVP concentration. Such stimulatory effect of the latter peptide on AVP output from the neurohypophysis was reduced by an intravenous (iv) injection of melatonin, which itself (at a concentration of 5 ng/ml) caused a significant decrease in AVP release 10 min after injection. The inhibitory influence of melatonin on the AVP secretion was absent in rats injected icv with both tachykinin receptors antagonists, the NK-2 receptor agonist or NKA. The present data indicate a distinct role for NK-1 receptor in NKA/SP-mediated regulation of AVP release from the rat H-NH system. They have also shown that, under present experimental conditions, the stimulatory effect of NK-1 receptor activation on AVP secretion into the blood is sensitive to inhibitory influence of melatonin.
17

Glucagon-like peptide-1 [7-36] amide and the release of neurohypophysial hormones: in vivo and in vitro studies

81%
Bojanowska E., Stempniak B., Juszczak M.
Journal of Physiology and Pharmacology. Supplement
|
2001
|
tom 52
|
nr 2
18

The effect of melatonin on oxytocin release under stress conditions

71%
Juszczak M., Stempniak B., Bojanowska E., Guzek J. W., Dabrowski R.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
19

LHRH - a heuromodulator of the hypothalamoneurohypophysial system activity

71%
Bojanowska E., Stempniak B., Juszczak M., Guzek J. W., Dabrowski R.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
20
Content available remote

Experimental hypothyroidism increases content of collagen and glycosaminoglycans in the heart

51%
Drobnik J., Ciosek J., Slotwinska D., Stempniak B., Zukowska D., Marczynski A., Tosik D., Bartel H., Dabrowski R., Szczepanowska A.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 3
57-62
The connective tissue matrix of the heart remains under regulatory influence of the thyroid hormones. Some conflicting data describe the connective tissue changes in subjects with thyroid gland disorders. The aim of the study was to assess the changes of the connective tissue accumulation in the heart of rats in the state of hypothyroidism and to answer the question whether TSH is involved in mechanism of the observed phenomena. Hypothyroidism in rats was induced by methylotiouracil treatment or by thyreoidectomy. The thyroid hormones [freeT3 (fT3), freeT4 (fT4)] and pituitary TSH were measured in plasma with radioimmunological method. The glycosaminoglycans (GAG) and total collagen were measured in heart muscle of both left and right ventricles. Cells from the rat’s heart were isolated and cultured. The cells were identified as myofibroblasts by electron microscopy method. The effects of TSH in concentrations ranging from 0.002 to 20 mIU/ml, on connective tissue accumulation in heart myofibroblasts cultures were tested. The primary hypothyroidism was developed both in groups with thyroidectomy and with methylthiouracil. The levels of fT3 and fT4 both in rats with thyreoidectomy and animals treated with methylthiouracil were decreased and TSH level in these two experimental groups was elevated. In the heart of the rats with experimental hypothyroidism increased content of both GAG and collagen was found. Myofibroblast number in culture was increased by TSH. Regardless of the method of its induction, hypothyroidism increased collagen and GAG contents in the heart. TSH is not involved in regulation of collagen and glycosaminoglycans accumulation in the heart of rats affected with primary hypothyroidism.
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