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1

Nature, life and mind. An essay on the essence

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Marinkovic S., Pajic S., Tomic O.

Folia Morphologica

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2015

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tom 74

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nr 3

Background: Our long-standing scientific work and love to the fine art and nature for many years succeeded in making a unifying description of the three domains, at a time when a high specialisation in science, and even in art, has neglected the necessary entirety. Materials and methods: Some neurons of a rat cerebral cortex were labelled with true blue and photographed under a fluorescent microscope. A monkey brain was sectioned in the axial plane. Several slices of the human motor cortex were stained with cresyl violet. A cerebral hemisphere image was modified, and another image was created in Adobe Photoshop. Results: Some 10 billion years after the Big Bang life appeared on the Earth, reaching its peak with development of the brain. The humans started exploration of the local nature to survive, and the universe for psychological support. The antique philosophers Leucippes, Democritus and Heraclitus were the first to create a unifying atomic theory and to suggest the eternal movement of the matter. Newton and Kepler explained the movement of the celestial objects, whereas Einstein, Planck, Bohr, Hubbel, Howking and many others connected the quantum physics and elementary forces with the essence of the universe. Leonardo da Vinci, and later many others as well, united science and art. Philosophers and mathematicians created the phenomena which do not exist in nature. Conclusions: Nature designed the human brain, more complex than the universe itself, which in turn created millions of the artworks and scientific discoveries. The might of the mind in some domains overcomes the power of nature. (Folia Morphol 2015; 74, 3: 273–282)

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Vascularisation of the geniculate ganglion

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Dozic A., Cetkovic M., Marinkovic S., Mitrovic D., Grujicic M., Micovic M., Milisavljevic M.

Folia Morphologica

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2014

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tom 73

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nr 4

Background: Lack of the relevant data in the literature and possible clinical significance of the geniculate ganglion vasculature inspired us to examine the vessels of this ganglion. Materials and methods: Twelve temporal bones were taken during autopsy and microdissected. Four geniculate ganglions were taken as well, serially sectioned and used for haematoxylin-eosin and trichrome staining, and for CD34 immunostaining. Results: The geniculate ganglion was supplied by the petrosal artery, which averaged 1.1 in number, 0.44 mm in the outer diameter, 0.24 mm in the luminal diameter, and 17.1 mm in length. The artery approached the greater petrosal nerve, giving off 1–3 twigs to it with a mean diameter of 24 µm, and entered the nerve hiatus or a small bone opening close to the ganglion. Before the artery continued to the tympanic segment of the facial nerve, it gave rise to 1 (8.33%), 2 (75.00%) or 3 (16.67%) branches to the geniculate ganglion, which ranged in diameter between 18 µm and 56 µm (mean 29 µm). From the formed superficial network, several twigs penetrated the ganglion and built an intraganglionic plexus. The counting, performed in microscopic fields, each measuring 341.7 µm × 250.0 µm in size, contained between 20 and 38 (mean 28.1) ganglion cells, as well as from 87 to 143 microvessels (mean 99.8), so that the neuron/vessel ratio was 1:3.6. Conclusions: This is the first detailed examination of the geniculate ganglion vasculature. The obtained data could be of clinical importance, especially in relation to the Bell’s palsy, ganglionitis, geniculate neuralgia, petrous bone imaging, and operations in the same region. (Folia Morphol 2014; 73, 4: 414–421)

3

Craniovertebral anomalies associated with pituitary gland duplication

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Milic I., Samardzic M., Djoric I., Tasic G., Djulejic V., Marinkovic S.

Folia Morphologica

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2015

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tom 74

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nr 4

Background: An extremely rare occurrence of the pituitary gland duplication inspired us to examine in detail the accompanying craniovertebral congenital anomalies in a patient involved. Materials and methods: T1-wighted magnetic resonance imaging (MRI) was performed, as well as the multislice computerised tomography (MSCT) and MSCT angiography in our patient, as well as in a control group of 10 healthy subjects. Results: In a 20-year-old male a double pituitary gland was identified, as well as hypothalamic enlargement, tuberomamillary fusion and hamartoma. In addition, the patient also showed a duplicated hypophyseal fossa and posterior clinoid processes, notch of the upper sphenoid, prominent inner relief of the skull, inverse shape of the foramen magnum, third occipital condyle, partial aplasia of the anterior and posterior arches of the atlas with a left arcuate foramen, duplication of the odontoid process and the C2 body, and fusion of the C2–C4 and T12–L1 vertebrae. The MSCT angiography presented a segmental dilatation of both vertebral arteries and the A2 segment of the anterior cerebral artery, as well as a duplication of the basilar artery. Conclusions: This patient is unique due to complex craniovertebral congenital anomalies associated with a duplication of the pituitary gland. (Folia Morphol 2015; 74, 4: 524–531)

4

A 3 tesla magnetic resonance imaging volumetric analysis of the hippocampal formation: dependence on handedness and age

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Lazic D., Stosic-Opincal T., Petronijevic N., Puskas L., Djulejic V., Milic I., Marinkovic S.

Folia Morphologica

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2015

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tom 74

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nr 4

Background: The hippocampal formation (HF) is one of the most important parts of the brain in the magnetic resonance imaging (MRI) volumetric analysis in various domains, but not completely from all aspects, including the handedness. The aim of our study was to evaluate the possible differences in the volume of the right and left HF among the healthy right-handed and left-handed subjects, and to determine whether the volume differences are age related. Materials and methods: The MRI of this prospective study was performed using T1 fast field echo (FFE) sequence. The 124 subsequent coronal slices (thickness 1.5 mm) were performed in each participant. The obtained HF volumes were normalised and statistically compared. Volunteers comprised 30 persons aged 22.0 years, 12 of whom were the left-handed, and 30 persons aged 75.2 years on average, 9 of whom were the left-handed. Results: The right and left HF volumes averaged 2.986 cm³ and 2.858 cm³ in the right-handed, and 2.879 cm³ and 3.020 cm³ in the left-handed young volunteers, as well as 2.728 cm³ and 2.650 cm³ in the right-handed, and 2.617 cm³ and 2.780 cm³ in the left-handed elderly persons. The HF volume ratios in the young left-handed participants showed a significant left-greater-than-right asymmetry. A significant difference was also noticed within the right-to-left volume ratios of the right- and left-handed young and elderly participants. The latter reduction in the HF volume within the aged group can be interpreted as a slight atrophy of the HF. Conclusions: There is a significant difference in the volumes of the left and right HF of the left-handed young participants. The age related HF volume differences were proven between the groups of the young and elderly volunteers. The obtained data should be included into the future MRI studies of the HF volumes in various clinical domains. (Folia Morphol 2015; 74, 4: 421–427)

5

Structure and immunohistochemistry of the human lenticulostriate arteries

76%

Marinkovic S., Todorovic V., Drndarevic N., Puskas L., Lazic D., Bojic V., Milic I.

Folia Morphologica

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2013

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tom 72

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nr 3

Background: Data about the structure and immunohistochemistry of the lenticulostriate arteries (LSAs), although very important for medical research and clinical practice, have been rarely reported in literature. Materials and methods: Fourty serially sectioned LSAs were stained with hematoxilin and eosin, and prepared for immunohistochemistry. Results: Our examination revealed a typical endothelial lining and a narrow subendothelial space with subintimal smooth muscle cells occasionally. The internal elastic lamina was fragmented or absent in the smallest LSAs branches. The media coat, with a mean diameter of 148.5 μm, contained typical smooth muscle cells which formed 14.2 layers on average and showed a positive immune reactions for alfa-actin, desmine, laminin and collagen IV. The thin adventitial coat contained fibroblasts, collagen fibers, and nerve bundles, with the strongest immunopositivity to thyrosin hydroxilase. The immune reactions against CD31 and CD34 proteins, endothelial nitric oxide synthase, S 100 protein, neurofilament protein and synaptophysin, seem to be performed in the LSAs wall for the first time. Similarly, the thickness of the LSAs wall and its coats have never been reported, nor the number of the smooth muscle cell layers. Conclusions: Our results related to the structure and immunohistochemistry of the LSAs could be important in cerebrovascular pathology, neurology and neurosurgery. (Folia Morphol 2013; 72, 3: 210–216)

6

Heart in anatomy history, radiology, anthropology and art

76%

Marinkovic S., Lazic D., Kanjuh V., Valjarevic S., Tomic I., Aksic M., Starcevic A.

Folia Morphologica

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2014

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tom 73

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nr 2

Background: Anthropologic, artistic and medical significance of heart inspired us to undertake this multidisciplinary study. Materials and methods: Amongst the 24 obtained echocardiograms and phonograms, 1 was used for a Photoshop processing. In addition, over 20,000 artwork reproductions were examined in this study. Results: Artistic and symbolic presentation of heart started some 15,000 years ago. First heart models were made by the Egyptian and Olmec civilisations. Ancient cultures regarded heart as the seat of the soul, spirit and intelligence. First anatomical and artistic images of heart were created by Leonardo da Vinci in the 15th century, and first wax models by the Italian anatomists in the 17th century. Mediaeval religious symbolism of heart was replaced in the Renaissance and later on mainly by its role in the romantic love. Anatomical heart art continued in the 18th and 19th centuries through the works of Sénac, Cloquet, Hirschfeld and Bourgery. Some modern artists, such as Dalí, Kahlo, Rivera, Warhol, Ivanjicki, Vital, Kober and Mastrlova, created the anatomical heart images or sculptures, whereas some others, such as Duchamp, Klee, Miró, Matisse and Dine, presented heart symbol in their artworks. New radiologic technologies produce fine images of heart, some of which are similar to the works of modern artists. Conclusions: Heart biology and symbolism have had a tremendous influence on our culture, including art and medical sciences. New radiologic techniques and computer technology have produced such images of heart, which substantially improved diagnosis, but also enhanced the heart aesthetics. (Folia Morphol 2014; 73, 2: 103–112)

7

Anatomy and radiology of the variations of aortic arch branches in 1,266 patients

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Vucurevic G., Marinkovic S., Puskas L., Kovacevic I., Tanaskovic S., Radak D., Ilic A.

Folia Morphologica

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2013

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tom 72

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nr 2

Background: The most reliable data about arterial variations, which are very important in surgery and radiology, can be obtained from a large series of patients. Materials and methods: We examined angiographic and multislice computerised tomography (MSCT) images in a group of 1,265 patients and in 1 dissected specimen. Results: While in 946 (74.72%) of the patients a normal vascular pattern (type I) was noticed, in the remaining 320 (25.28%) patients variations of the branches of the aortic arch were found, which were classified into types II through VIII and a few subtypes. Type II (2.84%) comprised a common origin of the left common carotid and subclavian arteries. Type III (15.56%) was related to an origin of the left subclavian artery from the brachiocephalic trunk. Type IV (0.55%) included the aortic origin of both common carotid and subclavian arteries, with the right subclavian artery having a retroesophageal course. Type V (0.24%) included the same 4 supra-aortic branches, which, however, arose from a double or a right- -sided aortic arch. Type VI (3.63%) comprised the aortic origin of the left vertebral artery, type VII (0.24%) the same origin of the right vertebral artery, and type VIII (2.22%) the aortic origin of the thyroidea ima artery. A corresponding embryological background and clinical implications of the described aberrant vessels were presented. Conclusions: In more than one quarter of the cases, the branching pattern of the examined arteries did not follow the classical pattern. Detailed knowledge of aortic branch variations is of great significance in anatomy, embryology, and clinical medicine, especially in radiology and thoracic surgery. (Folia Morphol 2013; 72, 2:113–122)

8

Brain and art: illustrations of the cerebral convolutions. A review

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Lazic D., Marinkovic S., Tomic I., Mitrovic D., Starcevic A., Milic I., Grujicic M., Markovic B.

Folia Morphologica

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2014

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tom 73

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nr 3

Background: Aesthetics and functional significance of the cerebral cortical relief gave us the idea to find out how often the convolutions are presented in fine art, and in which techniques, conceptual meaning and pathophysiological aspect. Materials and methods: We examined 27,614 artworks created by 2,856 authors and presented in art literature, and in Google images search. Results: The cerebral gyri were shown in 0.85% of the artworks created by 2.35% of the authors. The concept of the brain was first mentioned in ancient Egypt some 3,700 years ago. The first artistic drawing of the convolutions was made by Leonardo da Vinci, and the first colour picture by an unknown Italian author. Rembrandt van Rijn was the first to paint the gyri. Dozens of modern authors, who are professional artists, medical experts or designers, presented the cerebral convolutions in drawings, paintings, digital works or sculptures, with various aesthetic, symbolic and metaphorical connotation. Some artistic compositions and natural forms show a gyral pattern. The convolutions, whose cortical layers enable the cognitive functions, can be affected by various disorders. Some artists suffered from those disorders, and some others presented them in their artworks. Conclusions: The cerebral convolutions or gyri, thanks to their extensive cortical mantle, are the specific morphological basis for the human mind, but also the structures with their own aesthetics. Contemporary authors relatively often depict or model the cerebral convolutions, either from the aesthetic or conceptual aspect. In this way, they make a connection between the neuroscience and fine art. (Folia Morphol 2014; 73, 3: 247–258)

9

Morphometric multislice computed tomography examination of the craniovertebral junction in neck flexion and extension

64%

Marinkovic S., Milic I., Djoric I., Brigante L., Miljatovic A., Puskas L., Kapor S., Boljanovic J.

Folia Morphologica

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2017

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tom 76

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nr 1

Background: Detailed study of the craniovertebral junction (CVJ) is necessary to completely understand the mechanism of its flexion and extension. Materials and methods: One cadaver head was sectioned in the sagittal plane. Also, in 22 volunteers, examined using the multislice computed tomography (MSCT), 14 parameters and 2 angles were measured in the neutral position, flexion and extension. Results: The obtained measurements showed the anterior part of the occiput to move inferiorly in flexion, and the anterior atlas arch and the tip of the dens to get closer to the basion. At the same time, the opisthion moves superiorly, but the cervical spine bends anteriorly. Consequently, the dens-opisthion diameter and the opisthion-posterior atlas arch distance slightly decrease in length, whilst the arches of the atlas (C1), axis (C2) and C3 vertebra become more distant. Following extension, the posterior part of the occiput moves inferiorly, so that the basion-dens tip, the basion-axis arch, and the basion-posterior atlas arch distances increase in length. In contrast, the distances of the C1–C3 arches decrease in length. The angle between the foramen magnum and the dens tip decreases 1.620 on average in flexion, but increases 3.230 on average in extension. The angle between the axis body and the opisthion also decreases in flexion (mean, 3.360) and increases in extension (mean, 6.570). Among the congenital anomalies, a partial agenesis of the posterior atlas arch was revealed (4.5%), as well as an anterior dehiscence of the C1 foramen transversarium (13.6%). Conclusions: The mentioned measurements improved our understanding of the CVJ biomechanics. The obtained data can be useful in the evaluation of the CVJ instability caused by trauma, congenital anomalies and certain spine diseases. (Folia Morphol 2017; 76, 1: 100–109)

10

Kinematic magnetic resonance imaging study of the brain stem and cervical cord by dynamic neck motion

64%

Malis M., Georgievski B., Milic I., Mijatovic A., Kovacevic V., Lazic D., Kapor S., Marinkovic S.

Folia Morphologica

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2016

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tom 75

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nr 4

Background: The aim was to examine the position of the brain stem and cervical cord following the neck flexion and extension. Materials and methods: The serial sagittal T2-weighted magnetic resonance imaging (MRI) sections of the cervical cord and brain stem were made in 6 volunteers. The images were mainly used to measure certain distances and angles of the brain stem and cervical cord in the neutral position, and then following the head and neck flexion and extension. Results: The measurements showed that the pons is slightly closer to the clivus following the neck flexion; the medulla oblongata is somewhat distant to the basion but closer to the odontoid process. At the same time, the spino-medullary angle diminishes in size. On the other hand, the upper cervical cord slightly approaches the posterior wall of the spinal canal, the lower cervical cord is closer to the anterior wall, while the angle between them is significantly larger in size. After the cervical cord extension, the rostral pons is somewhat distant to the clivus, whereas the caudal pons and the medulla are slightly closer to the clivus and the basion. At the same time, the spino-medullary angle diminishes in size. The cervical cord is mainly closer to the posterior wall of the spinal canal, whilst its angle is significantly smaller. Conclusions: The obtained results regarding the brain stem and cervical cord motion can be useful in the kinetic MRI examination of certain congenital disorders, degenerative diseases, and traumatic injuries of the craniovertebral junction and the cervical spine. (Folia Morphol 2016; 75, 4: 439–447)

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Anatomy of the feeding arteries of the cerebral arteriovenous malformations

64%

Milatovic B., Saponjski J., Huseinagic H., Moranjkic M., Milosevic Medenica S., Marinkovic I., Nikolic I., Marinkovic S.

Folia Morphologica

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2018

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tom 77

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nr 4

Background: Identification and anatomic features of the feeding arteries of the arteriovenous malformations (AVMs) is very important due to neurologic, radiologic, and surgical reasons. Materials and methods: Seventy-seven patients with AVMs were examined by using a digital subtraction angiographic (DSA) and computerised tomographic (CT) examination, including three-dimensional reconstruction of the brain vessels. In addition, the arteries of 4 human brain stems and 8 cerebral hemispheres were microdissected. Results: The anatomic examination showed a sporadic hypoplasia, hyperplasia, early bifurcation and duplication of certain cerebral arteries. The perforating arteries varied from 1 to 8 in number. The features of the leptomeningeal and choroidal vessels were presented. The radiologic examination revealed singular (22.08%), double (32.48%) or multiple primary feeding arteries (45.45%), which were dilated and elongated in 58.44% of the patients. The feeders most often originated from the middle cerebral artery (MCA; (23.38%), less frequently from the anterior cerebral artery (ACA; 12.99%), and the posterior cerebral artery (PCA; 10.39%). Multiple feeders commonly originated from the ACA and MCA (11.69%), the MCA and PCA (10.39%), the ACA and PCA (7.79%), and the ACA, MCA and PCA (5.19%). The infratentorial feeders were found in 9.1% of the AVMs. Contribution from the middle meningeal and occipital arteries was seen in 3.9% angiograms. Two cerebral arteries had a saccular aneurysm. The AVM haemorrhage appeared in 63.6% of patients. Conclusions: The knowledge of the origin and anatomic features of the AVMs feeders is important in the explanation of neurologic signs, and in a decision regarding the endovascular embolisation, neurosurgical and radiosurgical treatments. (Folia Morphol 2018; 77, 4: 656–669)

Ograniczanie wyników

Nature, life and mind. An essay on the essence

Vascularisation of the geniculate ganglion

Craniovertebral anomalies associated with pituitary gland duplication

A 3 tesla magnetic resonance imaging volumetric analysis of the hippocampal formation: dependence on handedness and age

Structure and immunohistochemistry of the human lenticulostriate arteries

Heart in anatomy history, radiology, anthropology and art

Anatomy and radiology of the variations of aortic arch branches in 1,266 patients

Brain and art: illustrations of the cerebral convolutions. A review

Morphometric multislice computed tomography examination of the craniovertebral junction in neck flexion and extension

Kinematic magnetic resonance imaging study of the brain stem and cervical cord by dynamic neck motion

Anatomy of the feeding arteries of the cerebral arteriovenous malformations