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1

Komórki macierzyste - rozpoznawanie oraz znaczenie w homeostazie płuc

100%
Biczysko M., Biczysko W.
Postępy Biologii Komórki
|
2015
|
tom 42
|
nr 3
2

CD56 [NCAM] antigen in glandular epithelium of human thyroid: light microscopic and ultrastructural study

71%
Zeromski J., Biczysko M., Stajgis P., Lawniczak M., Biczysko W.
Folia Histochemica et Cytobiologica
|
1999
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tom 37
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nr 1
3

Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer

61%
Gurgul E., Kasprzak A., Blaszczyk A., Biczysko M., Surdyk-Zasada J., Seraszek-Jaros A., Ruchala M.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 1
4

The immunohistochemical demonstration of parafollicular cells and evaluation of calcium-phosphate balance in patients with thyroid hemiagenesis

61%
Ruchala M., Szczepanek E., Sujka-Kordowska P., Zabel M., Biczysko M., Sowinski J.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 2
5

Inulin supplementation in rat model of pouchitis

51%
Drzymala-Czyz S., Banasiewicz T., Tubacka M., Majewski P., Biczysko M., Koscinski T., Drews M., Walkowiak J.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 3
Available data indicates potential effectiveness of prebiotic therapy in alleviating inflammation and prolonging the remission in inflammatory bowel disease. Documented successes of such therapies were the basis for this study. So far, there is no data related to the effectiveness of inulin application in symptomatic or severe pouchitis in humans or in animal model. The aim of the study was to determine the effect of inulin supplementation on the expression of intestinal inflammation and feeding efficiency in rats with induced pouchitis. Twenty-four Wistar rats were operated. After induction of pouchitis animals were randomly divided into control and supplementation groups receiving, respectively, semi-synthetic diet with or without inulin (in a lower (LD) or higher (HD) dose: 2.5 % or 5 % of total dietary content of mass) for a period of 6 weeks. Selected nutritional parameters were assessed throughout the study. Histopathological and immunohistochemical analysis of pouch mucosa specimens was also performed. The energy intake, weight gain, feeding efficiency, quality of stools were comparable in all studied groups. The intensity of inflammation (Moskovitz scale) and adaptive changes (Laumonier scale) did not differ between compared groups. The tissue expression of pro- and anti-inflammatory interleukins (IL-1α, IL-6, IL-10 and IL-12) was not different either. Inulin supplementation does not improve the quality of stools or the expression of intestinal inflammation in rats with induced pouchitis. It has no impact on the intensity of pouch adaptation or on feeding efficiency.
6

Alternative 3’ acceptor site in the exon 2 of human PAX8 gene resulting in the expression of unknown mRNA variant found in thyroid hemiagenesis and some types of cancers

51%
Szczepanek-Parulska E., Szaflarski W., Piatek K., Budny B., Jaszczynska-Nowinka K., Biczysko M., Wierzbicki T., Skrobisz J., Zabel M., Ruchala M.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 4
PAX8 gene encodes one of the transcription factors engaged in the regulation of proper development of thyroid gland as well as Müllerian and renal/upper urinary tracts. So far, six alternatively spliced transcripts were reported, however, sequences of only four were deposited in the NCBI database. Here, we evaluate a fragment of a novel variant of PAX8 mRNA formed by an alternative 3' acceptor site located in the second exon. The molecular outcome encompasses extension of the 5' untranslated region of exon two by 97 nucleotides as is evident from mRNA. This new insert may impair binding of mRNA to the ribosome and in consequence significantly decrease expression of the PAX8 protein. Here, we show for the first time that the novel insert in exon two might be associated with congenital thyroid hemiagenesis and influence development of different types of cancer.
7

Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer - the DNA microarray assay

42%
Stojcev Z., Banasiewicz T., Kaszuba M., Sikorski A., Szczepkowski M., Bobkiewicz A., Paszkowski J., Krokowicz L., Biczysko M., Szmeja J., Jurkowska M., Majewski P., Mackiewicz A., Lamperska K., Drews M., Wojciechowicz J.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 2
 Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.
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