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1

A comparative approach to computer aided design model of a dog femur

100%
Turamanlar O., Verim O., Karabulut A.
Folia Morphologica
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2016
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tom 75
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nr 4
Computer assisted technologies offer new opportunities in medical imaging and rapid prototyping in biomechanical engineering. Three dimensional (3D) modelling of soft tissues and bones are becoming more important. The accuracy of the analysis in modelling processes depends on the outline of the tissues derived from medical images. The aim of this study is the evaluation of the accuracy of 3D models of a dog femur derived from computed tomography data by using point cloud method and boundary line method on several modelling software. Solidworks, Rapidform and 3DSMax software were used to create 3D models and outcomes were evaluated statistically. The most accurate 3D prototype of the dog femur was created with stereolithography method using rapid prototype device. Furthermore, the linearity of the volumes of models was investigated between software and the constructed models. The difference between the software and real models manifests the sensitivity of the software and the devices used in this manner. (Folia Morphol 2016; 75, 4: 550–554)
2

The effect of diclofenac sodium on neural tube development in the early stage of chick embryos

76%
Ertekin T., Bilir A., Aslan E., Koca B., Turamanlar O., Ertekin A., Albay S.
Folia Morphologica
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2019
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tom 78
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nr 2
Background: Neural tube defects are congenital malformations of the central nervous system. Genetic predisposition and some environmental factors play an important role in the development of neural tube defects. This study aimed to investigate the effects of diclofenac sodium on the neural tube development in a chick embryo model that corresponds to the first month of vertebral development in mammals. Materials and methods: Seventy-five fertile, specific pathogen-free eggs were incubated for 28 h and were divided into five groups of 15 eggs each. Diclofenac sodium was administered via the sub-blastodermic route at this stage. Incubation was continued till the end of the 48th h. All eggs were then opened and embryos were dissected from embryonic membranes and evaluated morphologically and histopathologically. Results: It was determined that the use of increasing doses of diclofenac sodium led to defects of midline closure in early chicken embryos. There were statistically significant differences in neural tube positions (open or close) among the groups. In addition; crown–rump length, somite number were significantly decreased in high dose experimental groups compared with control group. Conclusions: This study showed that development of neurons is affected in chicken embryos after administration of diclofenac sodium. The exact teratogenic mechanism of diclofenac sodium is not clear; therefore it should be investigated. (Folia Morphol 2019; 78, 2: 307–313)
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