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1
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Oznaczanie aktywności oksytocynazy (EC 3.4.1.2.) w surowicy krwi kobiet ciężarnych

100%
Jozwik M., Glowacka D., Rozanski A.
Diagnostyka Laboratoryjna
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1981
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tom 17
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nr 1
2
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Występowanie wanadu w wodach do picia z terenu województwa białostockiego

100%
Hoffmann B., Komenda W., Sadowska A., Rozanski A.
Roczniki Państwowego Zakładu Higieny
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1972
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tom 23
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nr 2
3

Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d[CGCGAATTCGCG]2

100%
Bielawski K., Bielawska A., Bartulewicz D., Rozanski A.
Acta Biochimica Polonica
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2000
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tom 47
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nr 3
A molecular mechanics and molecular dynamics approach was used to examine the structure of complexes formed between the d(CGCGAATTCGCG)2 duplex and netropsin, distamycin, and four carbocyclic analogues of netropsin and distamycin (1-4). The resulting structures of the ligand-DNA model complexes and their energetics were examined. It is predicted that the compounds 1-4 should have a decreased affinity for the minor groove of AT-rich regions in comparison to netropsin and distamycin. From the energetic analysis it appears that van der Waals and electrostatic interactions are more important than specific hydrogen bonds in stabilizing the ligand-duplex complexes. We predict that compounds 1 and 2 are effectively isohelical with the DNA minor groove. The superior DNA-binding afforded by 1 and 2 in comparison to 3 and 4 results from their more effective penetration into the minor groove and smaller perturbation of molecular structure upon complex formation.
4

New carbocyclic analogues of netropsin: synthesis and inhibition of topoisomerases

100%
Puckowska A., Bielawski K., Bielawska A., Rozanski A.
Acta Biochimica Polonica
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2002
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tom 49
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nr 1
A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 uM concentration.
5

Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin - new carriers of alkylating elements

88%
Bartulewicz D., Markowska A., Wolczynski S., Dabrowska M., Rozanski A.
Acta Biochimica Polonica
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2000
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tom 47
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nr 1
A series of netropsin and distamycin analogues was synthesised and investigated by molecular modelling. The lowest-energy conformations of four carbocyclic lexitropsins, potential carriers of alkylating elements, were obtained using the HyperChem 4.0 program, and compared with the DNA-lexitropsin crystal structures from the Brookhaven National Laboratory Protein Data Bank. A method for synthesis of carbocyclic lexitropsins was elaborated, with the use of a nitro group or azobenzene as precursors for the aromatic amino group. The influence of methoxy group in ortho position with respect to amide groups on the activity of the new compounds was investigated. All of the compounds tested showed high antitumour activity in the standard cell line of mammalian tumour MCF-7.
6

Formation and metabolism of N-nitrosamines

88%
Rostkowska K., Zwierz K., Rozanski A., Moniuszko-Jakoniuk J., Roszczenko A.
Polish Journal of Environmental Studies
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1998
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tom 07
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nr 6
Formation of nitrosamines and reactions of the first and second phase of their biotransformations were reviewed
7

Synthetic analogues of netropsin and distamycin-synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics

76%
Bartulewicz D., Bielawski K., Markowska A., Zwierz K., Puckowska A., Rozanski A.
Acta Biochimica Polonica
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1998
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tom 45
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nr 1
A new series of pyridine-containing analogues III-XXII of distamycin A and netropsin was investigated by the molecular mechanics technique and molecular modelling. A pyridine analogue of netropsin (VII) is described, the first compound based on molecular studies, and two carbocyclic analogues of distamycin A with an N-terminal chloro- or bromoacetyl group (VIa, VIIa) were synthesized, as well as carbocyclic analogues of netropsin (VIIIb, Xb), potential carriers of alkylating elements. The potential use of VIa, VII, VIIa, VIIIb and Xb as carriers to place into the minor groove of DNA chemical groups capable of modifying DNA, is discussed.
8

Activity of lysosomal exoglycosidases of rat alimentary tract in chronic exposure to N-nitrosodimethylamine

76%
Rostkowska K., Zwierz K., Arciuch L. P., Rozanski A., Moniuszko-Jakoniuk J., Roszczenko A.
Polish Journal of Environmental Studies
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1998
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tom 07
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nr 5
There is observed increasing pollution of environment by nitrosocompounds. Acute intoxication of animals by nitrosocompounds lead to necrosis and chronic exposure to neoplasm. We have little information on the influence of nitrosocompounds on metabolism of glycoconjugates (glycoproteins, glycolipids and proteoglycans) in animals. The aim of our work is evaluation the influence of exposure of rats for 10 and 90 days to N-nitrosodimethylamine (NDMA), on activity of lysosomal exoglycosidases (enzymes hydrolysing terminal sugars in oligosaccharides) in the alimentary tract. It was found that intoxication of rats with NDMA increased specific activity of N-acetyl-b-hexosaminidase, b-galactosidase and a-mannosidase in majority of tissues of rat alimentary tract. Damage the cells of alimentary tract by NDMA or its metabolites, increase activity of exoglycosidases, because damaged tissue elements must be removed by catabolic enzymes before restoration processes can start.
9

Isoenzymes of N-acetyl-beta-hexosaminidase in complicated pregnancy

76%
Arciuch L. P., Bielecki D., Borzym M., Poludniewski G., Arciszewski K., Rozanski A., Zwierz K.
Acta Biochimica Polonica
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1999
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tom 46
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nr 4
The activity of N-acetyl-β-hexosaminidase was found to be significantly higher in the placentas collected after delivery from women in puerperium with symptoms of prolonged pregnancy or complicated by EPH gestosis, than in placentas from normal pregnancy. Isoelectrofocusing of placenta homogenates showed the presence of isoenzymes A, P and B of N-acetyl-β-hexosaminidase. Different isoenzyme A patterns in homogenates were observed in placentas obtained from normal and prolonged pregnancies and in those complicated by EPH gestosis.
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