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1
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Acute toxicity of sodium salinomycin in Synvertas plv. ad us.vet. preparation in chickens

100%
Neuschl J., Saly J., Simko S., Magic D., Sevcikova Z., Kremen J., Nagy J., Korim P.
Bulletin of the Veterinary Institute in Puławy
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2001
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tom 45
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nr 2
The work presents an initial information about degree of toxicological risk for chickens treated with sodium salinomycin in the Slovak anticoccidial (Synvertas plv. ad us. vet., Biotika, Slovenská L’upča, Slovak Republic), under conditions of acute intoxication. Median lethal dose (LD₅₀) of sodium salinomycin in Synvertas plv. ad us. vet. preparation (Biotika) has been determined in 2 and 4-week-old chickens, both sexes, meat type Ross breed. Clinical symptoms of poisoning and patho-morphological changes in dead chickens have been observed as well. Development of clinical symptomatology of poisoning and decrease in intoxication symptoms in 4-weeks-old chickens has been observed even after a single administration of sodium salinomycin in sublethal doses : 20, 30, 40, 50, and 70 mg.kg⁻¹ of body weight (b. w.). LD₅₀ of sodium salinomycin in the objective preparation was calculated on double dose by the interpolation method according to Roth et al. (21) on mortality within 24 h. LD₅₀ value of sodium salinomycin in Synvertas preparation was determined at 102 mg.kg⁻¹ of b. w. (1020 mg of preparation) in 2-week-old chickens and at 106 mg.kg⁻¹ of b. w. (1060 mg of preparation) in 4-week-old ones. From clinical signs of intoxication after lethal doses of 100 and 120 mg of sodium salinomycin per kg⁻¹ of b. w. (1000 and 1200 mg of preparation), the following signs were in the foreground: ataxia, lying on the side or in sternal position with forward stretched neck and legs stretched backward, dyspnoea, cyanosis, sharp CNS inhibition, loss of acoustic and touch reactions. Death occured within 12 h and was accompanied by mild myoclonus symptoms (3-4) with backward stretched limbs. Hyperaemia of the liver, pancreas, spleen and kidneys, anaemia of GIT mucosa, diffuse acute bronchopneumonia, in one chicken lung oedema, slight anaemia of thoracic musculature, slight banding of thigh and thoracic musculature were recorded in most dead chickens. The toxic effect of sodium salinomycin started to manifest itself in 4-week-old chickens after sublethal dose of 20 mg.kg⁻¹ of b. w. (200 mg of preparation). Poisoning symptoms were very weak and disappeared after 15 h.
2

Effect of lead on health and productivity of layers

100%
Saly J., Baranova D., Pesek L., Sevcikova Z., Koscik D., Sutiak V., Neuschl J., Kremen J.
Bulletin of the Veterinary Institute in Puławy
|
2004
|
tom 48
|
nr 1
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Subacute toxicity of sodium salinomycin in the anticoccidial preparation Synvertas plv.ad us.vet. in chickens

100%
Neuschl J., Saly J., Simko S., Magic D., Tuckova M., Lenhardt L., Nagy J., Kremen J.
Bulletin of the Veterinary Institute in Puławy
|
2001
|
tom 45
|
nr 2
The study presents information about the toxic action of sodium salinomycin in the anticoccidial preparation Synvertas, plv. ad us. vet. (Biotika, Slovenská L’upča, Slovak Republic), in chickens under the conditions of subacute intoxication. The experiment was carried out in chickens of the meat hybrid Ross of both sexes, 5 weeks old. The first experimental group of chickens (n=10) was administered sodium salinomycin at a dose of 5.3 mg/kg b.w. (53 mg of the preparation) which corresponded to 1/20 of LD₅₀. The second experimental group (n=10) was treated with sodium salinomycin at a dose of 10.6 mg/kg b.w. (106 mg of the preparation), i.e. 1/10 of LD₅₀. The preparation was administered once daily by a tube into a crop in the form of water suspension (1:5), at early hours for 7 d. The control group consisting of 6 chickens received the same volume of water in the same way as the experimental chickens. During the experiment, the chickens were fed mixed feed Hyd-03 ad libitum and had unlimited access to drinking water. We observed the overall health state of chickens and looked for possible clinical symptoms of intoxication, determined live body weight, haematological parameters (number of erythrocytes and leukocytes, leukogram, haemoglobin content and haematocrit value), biochemical parameters in blood serum (activity of aspartate aminotransferase, alanine aminotransferase and alkaline aminotransferase, total proteins, urea, bilirubin, cholesterol, calcium and phosphorus) and the presence of patho-morphological changes. The dose of 5.3 mg sodium salinomycin per kg b.w. in the respective preparation was tolerated well when administered for 7 d. and had no toxic effects on chickens. It did not influence adversely their health, weight gains, haematological and biochemical parameters and caused no patho-morphological changes. Sodium salinomycin at a dose of 10.6 mg/kg b. w. resulted in toxic effects manifested in growth depression, significantly increased content of urea and cholesterol and sporadic small intestine petechia. Clinical symptoms of intoxication were not observed. Our investigations point to good tolerance of the tested preparation Synvertas despite the fact that it was administered in relatively high doses.
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