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1
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Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy

100%
Hrelec M., Klicek R., Brcic L., Brcic I., Cvjetko I., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 7
2
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Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing

100%
Brcic L., Brcic I., Staresinic M., Novinscak T., Sikiric P., Seiwerth S.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 7
3
Content available remote

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice

84%
Boban Blagaic A., Turcic P., Blagaic V., Dubovecak M., Jelovac N., Zemba M., Radic B., Becejac T., Stancic Rokotov D., Sikiric P.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 7
4
Content available remote

Nonsteroidal anti-inflammatory drugs-induced failure of lower esophageal and pyloric sphincter and counteraction of sphincters failure with stable gastric pentadecapeptide BPC157 in rats

84%
Vitaic S., Stupnisek M., Drmic D., Bauk L., Kokot A., Klicek R., Vcev A., Luetic K., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 2
5
Content available remote

Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats

83%
Ilic S., Brcic I., Mester M., Filipovic M., Sever M., Klicek R., Barisic I., Radic B., Zoricic Z., Bilic V., Berkopic L., Brcic L., Kolenc D., Romic Z., Pazanin L., Seiwerth S., Sikiric P., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 7
6
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Antiinflammatory effect of BPC 157 on experimental periodontitis in rats

68%
Keremi B., Lohinai Z., Komora P., Duhaj S., Borsi K., Jobbagy-Ovari G., Kallo K., Szekely A. D., Fazekas A., Dobo-Nagy C., Sikiric P., Varga G.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 7
7
Content available remote

Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability

68%
Klicek R., Kolenc D., Suran J., Drmic D., Brcic L., Aralica G., Sever M., Holjevac J., Radic B., Turudic T., Kokot A., Patrij L., Rucman R., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 5
8
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An endogenous defensive concept, renewed cytoprotection/adaptive cytoprotection: intra(per)-oral/intragastric administration of strong alcohol in rat. Involvement of pentadecapeptide BPC 157 and nitric oxide system

68%
Becejac T., Cesarec V., Drmic D., Hirsl D., Madzarac G., Djakovic Z., Bunjevac I., Zenko Sever A., Sepac A., Batelja Vuletic L., Stancic Rokotov D., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 3
9
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High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)

60%
Ilic S., Drmic D., Zarkovic K., Kolenc D., Coric M., Brcic L., Klicek R., Radic B., Sever M., Djuzel V., Ivica M., Boban Blagaic A., Zoricic Z., Anic T., Zoricic I., Djidic S., Romic Z., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 2
We focused on stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, an anti-ulcer peptide efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported) because of its hepatoprotective effects. We investigate a particular aspect of the sudden onset of encephalopathy with extreme paracetamol overdose (5 g/kg intraperitoneally) so far not reported: rapidly induced progressive hepatic encephalopathy with generalized convulsions in rats. BPC 157 therapy (10 µg, 10 ng, 10 pg/kg, intraperitoneally or intragastrically) was effective (µg-ng range) against paracetamol toxicity, given in early (BPC 157 immediately after paracetamol, prophylactically) or advanced stage (BPC 157 at 3 hours after paracetamol, therapeutically). At 25 min post-paracetamol increased ALT, AST and ammonium serum values precede liver lesion while in several brain areas, significant damage became apparent, accompanied by generalized convulsions. Through the next 5 hour seizure period and thereafter, the brain damage, liver damage enzyme values and hyperammonemia increased, particularly throughout the 3-24 h post-paracetamol period. BPC 157 demonstrated clinical (no convulsions (prophylactic application) or convulsions rapidly disappeared (therapeutic effect within 25 min)), microscopical (markedly less liver and brain lesions) and biochemical (enzyme and ammonium serum levels decreased) counteraction. Both, the prophylactic and therapeutic benefits (intraperitoneally and intragastrically) clearly imply BPC 157 (µg-ng range) as a highly effective paracetamol antidote even against highly advanced damaging processes induced by an extreme paracetamol over-dose.
10
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Duodenocutaneous fistula in rats as a model for "wound healing-therapy" in ulcer healing: the effect of pentadecapeptide BPC 157, L-nitro-arginine methyl ester and L-arginine

60%
Skorjanec S., Kokot A., Drmic D., Radic B., Sever M., Klicek R., Kolenc D., Zenko A., Lovric Bencic M., Belosic Halle Z., Situm A., Zivanovic Posilovic G., Masnec S., Suran J., Aralica G., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 4
11
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BPC 157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure

60%
Petrovic I., Dobric I., Drmic D., Sever M., Klicek R., Radic B., Brcic L., Kolenc D., Zlatar M., Kunjko K., Jurcic D., Martinac M., Rasic Z., Boban Blagaic A., Romic Z., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 5
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