Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 10

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Surgical treatment of Parkinson's disease as a tool for an understanding of the basal ganglia function

100%
Friedman A.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 5
2

Is oxidative stress in Parkinson's disease mediated by a change in the ferritin structure?

75%
Friedman A.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Role of iron in pathogenesis of Parkinson disease

63%
Galazka-Friedman J., Friedman A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2011
|
tom 92
|
nr 2
4

Controversies about iron in parkinsonian and control substantia nigra

63%
Galazka-Friedman J., Friedman A.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 3
5

Choroba Parkinsona - fakty,opinie,hipotezy

50%
Friedman A.
Kosmos
|
1993
|
tom 42
|
nr 2
487-494
6

Procedural and declarative memory deficits in Parkinson's disease

45%
Gawrys L., Szatkowska I., Grabowska A., Friedman A., Kaczmarek L.
Acta Neurobiologiae Experimentalis
|
2007
|
tom 67
|
nr 3
7

Nonverbal deficits in explicit and implicit memory of Parkinson's disease patients

39%
Gawrys L., Szatkowska I., Jamrozik Z., Janik P., Friedman A., Kaczmarek L.
Acta Neurobiologiae Experimentalis
|
2008
|
tom 68
|
nr 1
This study examined verbal and nonverbal aspects of explicit and implicit memory in a sample of 19 Parkinson's disease (PD) patients and 21 control subjects. For implicit memory evaluation, we used a Mirror Reading (MR) task employing verbal material as well as a nonverbal Serial Reaction Time (SRT) task. For explicit memory measurement we applied a word pairs task (verbal) and pairs of a Japanese ideograms task (nonverbal). The PD patients displayed impairments in the nonverbal tasks only, namely, in the SRT task and the pairs of Japanese ideograms task. No correlation between Wisconsin Card Sorting Test (WCST) scores and the results of tasks in which PD patients displayed deficits (SRT and pairs of Japanese ideograms) were discovered. Interestingly, such a correlation was found in the case of MR and words pairs tasks, which did not distinguish PD patients from control group.
8

m levels of hepcidin and interleukin 6 in Parkinson’s disease

39%
Kwiatek-Majkusiak J., Geremek M., Koziorowski D., Tomasiuk R., Szlufik S., Friedman A.
Acta Neurobiologiae Experimentalis
|
2020
|
tom 80
|
nr 3
Neurodegeneration in Parkinson’s disease (PD) includes processes of chronic inflammation and oxidative stress which are related to dysregulation in the homeostasis of iron metabolism. Hepcidin is a peptide hormone responsible for systemic iron homeostasis and simultaneously the inflammatory response protein, induced in response to interleukin 6 (IL‑6). We assessed the serum concentration of hepcidin and IL‑6 in the groups of patients with PD treated only pharmacologically with optimal individualized therapy (MT) and treated additionally with deep brain stimulation (DBS), compared to the control group. The serum concentrations of hepcidin and IL‑6 in the group of all PD patients were significantly higher than in the control group. In the group of PD patients treated with DBS hepcidin and IL‑6 concentrations were significantly higher compared to the control group. Additionally, the positive correlations between serum hepcidin and IL‑6 were found in the PD (MT and DBS) and PD‑DBS group. The obtained results may indicate the influence of immunological mechanisms on iron metabolism and oxidative stress, in particular when the inflammatory process is more active in the DBS‑treated group. This effect can be protective as well as neurodegenerative.
9

Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer’s disease

39%
Kwiatek-Majkusiak J., Dickson D. W., Tacik P., Aoki N., Tomasiuk R., Koziorowski D., Friedman A.
Acta Neurobiologiae Experimentalis
|
2015
|
tom 75
|
nr 4
Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p<0.001, p=0.025, p=0.029). A significant correlation was also found between the concentration of L-ferritin and neuronal loss (p=0.0026). These findings indicate an important role of ferritin light chains in neurodegeneration, that is linked to chronic inflammation processes and the associated activation of the microglia rich of L chains.
10

Parkinson's disease leads to distorted interaction of episodic and working memory systems

27%
Gawrys L., Szatkowska L., Pilacinski A., Piatkowska-Janko E., Bogorodzki P., Wolak T., Friedman A., Sienkiewicz J., Koziorowski D., Janik P., Jamrozik Z., Krolicki L., Andrysiak R., Kulinski R., Kaczmarek L.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
Patients with Parkinson’s disease (PD) exhibit impairments in executive function and working memory. As opposed to motor symptoms of the disease the physiological origins of cognitive defi cits are not well understood. The aim of the present study was to delineate mechanisms of cognitive impairment in PD using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Twenty-two patient and 10 matched control subjects accomplished Wisconsin Card Sorting Test (WCST) – standard clinical measure of executive function and then underwent fMRI during performance of the N-Back working memory task.The correlation analysis comparing BOLD signal intensity changes with number of categories achieved in WCST revealed a signifi cant positive correlation within supramarginal gyrus, inferior parietal gyrus, middle and inferior frontal gyrus and caudate nucleus. Signifi cant negative correlations with executive impairment were observed within fusiform and parahippocampal gyrus, as well as enthorhinal and perirhinal cortex. These results suggest that cognitive impairment in PD may origin in consequence of distorted interaction between episodic and working memory systems.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.