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The influence of cyclosporine A, cyclothiazide and luzindole on the electroconvulsive threshold in mice

100%

Borowicz K. K.

Journal of Pre-Clinical and Clinical Research

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2007

|

tom 01

|

nr 1

2

Effect of three glutamatergic metabotropic receptor ligands on electrically-induced seizures in mice

100%

Borowicz K. K.

Journal of Pre-Clinical and Clinical Research

|

2007

|

tom 01

|

nr 1

3

Isobolographic interaction between AO-294, an enantiomer of losigamone, and phenobarbital in the mouse model of maximal electroshock

63%

Borowicz K. K., Jaszczyk B.

Journal of Pre-Clinical and Clinical Research

|

2007

|

tom 01

|

nr 1

4

Isobolographic interaction between AO-294, an enantiomer of losigamone, and valproate in the mouse model of maximal electroshock

63%

Borowicz K. K., Jaszczyk B.

Journal of Pre-Clinical and Clinical Research

|

2007

|

tom 01

|

nr 1

5

Effect of IEM 1460 - a selective antagonist of GluR2-lacking AMPA receptors - on the action of conventional antiepileptic drugs against maximal electroshock in mice

63%

Borowicz K. K., Banach M.

Journal of Pre-Clinical and Clinical Research

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2007

|

tom 01

|

nr 1

6

Influence of oxcarbazepine and its combination with SIB-1893 on body temperature in rats

51%

Luszczycki J. J., Borowicz K. K., Czuczwar S. J.

Journal of Pre-Clinical and Clinical Research

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2008

|

tom 02

|

nr 1

7

Interaction of excitatory amino acid antagonists and calcium channel inhibitors in the electroconvulsive test in mice

51%

Gasior M., Borowicz K. K., Kleinrok Z., Czuczwar S. J.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

|

nr 5

8

7-nitroindazole (a selective neuronal nitric oxide synthase inhibitor) differentially affects the anticonvczsive activity of conventional antiepileptics in mice

51%

Czuczwar S. J., Borowicz K. K., Kleinrok Z.

Acta Neurobiologiae Experimentalis

|

1997

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tom 57

|

nr 5

9

Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions

51%

Borowicz K. K., Piskorska B., Stepniak B., Czuczwar S. J.

Annals of Agricultural and Environmental Medicine

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2012

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tom 19

|

nr 3

Depression is becoming a growing problem in rural areas. This psychiatric disorder often accompanies epilepsy. The aim of this study was to assess the influence of fluoxetine (FXT), a commonly used antidepressant, on the protective action of two conventional antiepileptic drugs: ethosuximide (ETX) and valproate (VPA), against pentylenetetrazole (PTZ)-induced convulsions in mice. Motor coordination and long-term memory deficits induced by FXT, antiepileptic drugs alone and in combinations with FXT were assessed in the chimney test and passive-avoidance task, respectively. Brain concentrations of ETX and VPA were measured by immunofluorescence. Obtained results indicate that FXT at the dose of 15 mg/kg (ip, 30 min before the test) significantly increased the threshold for clonic convulsions. The antidepressant drug at lower doses remained ineffective in this respect. Moreover, FXT at the highest subprotective dose (10 mg/kg, ip) markedly enhanced the anticonvulsant effects of VPA, but not of ETX, against PTZ-induced seizures. The interaction between FXT and VPA seems to be pharmacodynamic because the antidepressant drug did not alter the brain concentration of VPA. With regard to adverse effects, FXT, VPA, ETX, and the combinations of FXT with antiepileptic drugs, did not impair motor coordination and long-term memory in mice. In conclusion, the combination of FXT with VPA may be advantageous in the treatment of myoclonic epilepsy, and therefore it should be recommended for further study in clinical conditions.

10

Anticonvulsant activity of convntional antiepileptic drugs unaltered by vinpocetine in mouse model of epilepsy

51%

Borowicz K. K., Swiader M., Banach M.

Journal of Pre-Clinical and Clinical Research

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2007

|

tom 01

|

nr 1

11

Neuroprotective effects of some newer and potential antiepileptic drugs

51%

Czuczwar S. J., Ferenc R., Blaszczyk B., Borowicz K. K.

Journal of Pre-Clinical and Clinical Research

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2007

|

tom 01

|

nr 1

12

Influence of several convulsants on the protective activity of a non-competitive AMPA-kainate antagonist, LY 300164, and lamotrigine against maximal electroshock in mice

39%

Borowicz K. K., Swiader M., Zgrajka W., Sawulski C., Turski W. A., Czuczwar S. J.

Journal of Physiology and Pharmacology

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2002

|

tom 53

|

nr 4,2

Aminophylline (50-100 mg/kg) and strychnine (0.125-0.5 mg/kg) significantly raised the ED50 values of LY 300164 against maximal electroshock in mice, from 4 to 8 mg/kg (aminophylline 100 mg/kg) and from 3.6 to 11.5 mg/kg (strychnine 0.5 mg/kg). Also, aminophylline (25-50 mg/kg) and strychnine (0.125-0.25 mg/kg) increased the ED50 value of lamotrigine in this test, for instance from 5.5 to 8.0 mg/kg (aminophylline 50 mg/kg) and from 5.2 to 8.9 mg/kg (strychnine 0.25 mg/kg). Moreover, the ED50s values of aminophylline and strychnine for the reduction of the anticonvulsant effect of LY 300164 (7 mg/kg, the dose equal to its ED97 value against maximal electroshock) were 79.9 and 0.2 mg/kg, respectively. The respective ED50 values for the inhibition of the antiseizure action of lamotrigine were 40.9 and 0.2 mg/kg. Neither bicuculline nor picrotoxin affected the protective action of LY 300164 or lamotrigine. Strychnine significantly lowered the plasma concentrations of LY 300164 and this my point to a pharmacokinetic mechanism of the observed interaction. Aminophylline did not affect the plasma concentrations of the studied anticonvulsant drugs and strychnine - that of lamotrigine, so a pharmacokinetic interaction does not seem probable. The present results indicate that the potential of aminophylline and strychnine to attenuate the anticonvulsant activity of conventional antiepileptics is extended to LY 300164 and lamotrigine.

Ograniczanie wyników

8 Journal of Pre-Clinical and Clinical Research

2 Acta Neurobiologiae Experimentalis

1 Annals of Agricultural and Environmental Medicine

1 Journal of Physiology and Pharmacology

12 Borowicz K. K.

6 Czuczwar S. J.

2 Banach M.

2 Jaszczyk B.

2 Kleinrok Z.

2 Swiader M.

1 Blaszczyk B.

1 Ferenc R.

1 Gasior M.

1 Luszczycki J. J.

1 Piskorska B.

1 Sawulski C.

1 Stepniak B.

1 Turski W. A.

1 Zgrajka W.

1 2012

1 2008

7 2007

1 2002

1 1997

1 1995

The influence of cyclosporine A, cyclothiazide and luzindole on the electroconvulsive threshold in mice

Effect of three glutamatergic metabotropic receptor ligands on electrically-induced seizures in mice

Isobolographic interaction between AO-294, an enantiomer of losigamone, and phenobarbital in the mouse model of maximal electroshock

Isobolographic interaction between AO-294, an enantiomer of losigamone, and valproate in the mouse model of maximal electroshock

Effect of IEM 1460 - a selective antagonist of GluR2-lacking AMPA receptors - on the action of conventional antiepileptic drugs against maximal electroshock in mice

Influence of oxcarbazepine and its combination with SIB-1893 on body temperature in rats

Interaction of excitatory amino acid antagonists and calcium channel inhibitors in the electroconvulsive test in mice

7-nitroindazole (a selective neuronal nitric oxide synthase inhibitor) differentially affects the anticonvczsive activity of conventional antiepileptics in mice

Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions

Anticonvulsant activity of convntional antiepileptic drugs unaltered by vinpocetine in mouse model of epilepsy

Neuroprotective effects of some newer and potential antiepileptic drugs

Influence of several convulsants on the protective activity of a non-competitive AMPA-kainate antagonist, LY 300164, and lamotrigine against maximal electroshock in mice