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1

Does selenium supplementaton with organic selenosemicarbazides improve neutrophil phagocytic activity?

100%
Musik I.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
2

Influence of different forms of selenium supplementation on the oxidant balance in the rat liver

63%
Musik I., Kielczykowska M.
Medycyna Weterynaryjna
|
2013
|
tom 69
|
nr 07
The aim of this study was to estimate the influence of the administration of two selenoorganic compounds of different structures, as well as inorganic sodium selenite, on antioxidant parameters and lipid peroxidation in rat liver tissue. Adolescent male Wistar rats were treated through a stomach tube with saline (control), Na₂SeO₃ (group II), 4-(o-tolyl-)-selenosemicarbazide of 2-chlorobenzoic acid (chain structure - group III), 3-(2-chlorobenzoylamino-)-2-(o-tolylimino-)-4-methyl-4-selenazoline (ring structure group IV) at a dose of 5 · 10⁻⁴ mg of Se g⁻¹ of b.w. once a day for a period of 10 days. Liver homogenates were examined to determine total antioxidant status (TAS), the activities of antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPx), the concentrations of ascorbic acid (AA) and reduced glutathione (GSH), as well as the concentration of malondialdehyde (MDA). TAS was significantly reduced in animals receiving selenoorganic compounds vs. control. SOD was unchanged and GPx decreased in all groups undergoing Se-administration vs. control. AA was decreased in group IV vs. both control and group II. GSH was unaltered vs. control in rats receiving selenocompounds. MDA was significantly decreased in group IV in comparison with all other groups. Selenium supplementation generally caused impairment of selected elements of antioxidant barrier, but the ring selenoorganic significantly decreased the lipid peroxidation level. Further studies with the use of diverse doses and longer supplementation periods, including studies concerning the action of selected selenoorganic compounds in pathological states, are needed to evaluate the usefulness of these substances as Se-supplements.
3
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Lithium and the application of its compounds in different fields of medicine

63%
Kielczykowska M., Musik I.
Journal of Elementology
|
2014
|
tom 19
|
nr 4
Although lithium has not been classified as an essential element for humans, it can influence numerous metabolic processes and exert diverse effects in the human body, both positive and negative ones. Its actions enable the use of lithium compounds in therapy of different illnesses. It is mostly used for cure of psychiatric disorders: as a mood stabilizer and for intensifying the action of antidepressants. However, its compounds have been also tried in other fields of medicine: as an adjuvant in patients with thyroid diseases undergoing radioiodine therapy, in dermatology, in cure of neurodegenerative and ophthalmic illnesses as well as in tumour therapy. Lithium displays beneficial action only within a determined range of its serum concentration and an overrun of the safe threshold can cause side effects. Due to this fact, the Li serum level as well as many other factors, e.g.: body weight, creatinine, renal and thyroid functions should be monitored during the whole therapy. Many studies were undertaken to clarify the mechanism by which lithium affects organisms but the results still remain unsatisfactory. Nevertheless, some interesting aspects of lithium action have been revealed, including its effect on the enzymatic activity, neurodegenerative processes, apoptosis, formation of cytokines as well as neurotransmission and oxidant balance.
4
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Level of magnesium in patients with depression treated with lithium – pilotage research

51%
Makara-Studzinska M., Dabrowski W., Kielczykowska M., Musik I.
Annals of Agricultural and Environmental Medicine
|
2013
|
tom 20
|
nr 1
Introduction. Depression is a major public health problem. Magnesium (Mg2+) is involved in many metabolic processes as an activator of over 300 different enzymes. For the last 60 years lithium (Li+) compounds have been used in psychiatry. Li+ salts are regarded as the first choice medicine in the treatment of affective disorders and are also applied as an adjuvant intensifying the therapy in drug-resistant depression patients. Objective. The objective of the study was an analysis of the relationship between the levels of magnesium, lithium, and education and place of residence of patients hospitalized due to depression. Material and methods. Patients with bipolar affective disorders undergoing lithium therapy during their stay in the Department of Psychiatry at the Medical University in Lublin were examined. Patients were divided into three groups according to education level and were also analyzed according to place of residence. Results. In the group of patients in the study, a significantly lower level of magnesium was found (p=0.02) in blood plasma of patients with secondary education level, compared to those who had elementary education. There was also a significantly higher level of magnesium (p=0.01) in blood plasma of patients who lived in urban areas, compared to rural inhabitants. No statistically significant differences were noted between lithium level in plasma, and the patients’ place of residence (p=0.34). Conclusion. Significantly higher plasma magnesium levels were observed among city than village inhabitants, there was also a relationship between type of education and magnesium level in blood plasma of the patients in the study. Further studies including larger groups of patients should be performed to enable a final conclusion.
5

Magnez i wapń w tkankach szczurów otrzymujących różne dawki litu

51%
Kielczykowska M., Pasternak K., Wronska J., Musik I.
Journal of Elementology
|
2004
|
tom 09
|
nr 4
6

Wpływ organicznych związków selenu na stężenie magnezu w wybranych tkankach oraz wskaźniki krwi myszy

51%
Musik I., Pasternak K., Kielczykowska M.
Journal of Elementology
|
2002
|
tom 07
|
nr 4
7

Comparison of the influence of selenium supplementation in organic and inorganic forms on oxidant/antioxidant balance in rat lungs

51%
Musik I., Kielczykowska M., Kocot J.
Bulletin of the Veterinary Institute in Puławy
|
2013
|
tom 57
|
nr 3
The aim of the experiment was to compare the effect of two newly synthesised organic selenocompounds with that exerted by sodium selenite on oxidant processes in rat lungs. Total antioxidant status (TAS), activity of antioxidant enzymes - superoxide dismutase (SOD) and glutathione peroxidase (GPx), concentrations of non-enzymatic antioxidants - ascorbic acid (AA) and reduced glutathione (GSH), concentration of lipid peroxidation marker - malonyldialdehyde (MDA), as well as tissue concentrations of silicon and magnesium were determined in rats receiving different selenocompounds (inorganic selenite and organic selenosemicarbazide in a chain form - compound A and selenazoline in a ring form - compound B). TAS values were elevated in comparison with control without Se-supplementation. GPx was insignificantly increased when compared to control, mainly in the group receiving compound B. Inorganic selenite significantly increased SOD and decreased levels of AA. MDA was slightly altered in Se-supplemented animals. Silicon levels were not affected, whereas magnesium concentrations were considerably reduced in all groups receiving selenium. Compound B increased TAS to the highest degree. It did not have any impact on components of the antioxidant barrier and slightly decreased MDA. Therefore, it could be suggested that further research, including in vitro studies on cancer cell lines, may reveal new possibilities of medical applications of selenocompounds.
8

The influence of metals administered in diet on the level of chosen elements of antioxidant barrier in rats

51%
Kielczykowska M., Pasternak K., Musik I., Wronska J.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
9
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The influence of selenium compounds of different structure on morphology, blood biochemistry and phagocytic capability of granulocytes in rats

51%
Musik I., Kielczykowska M., Donica H.
Roczniki Państwowego Zakładu Higieny
|
2013
|
tom 64
|
nr 2
Background. Selenium belongs to important microelements. Numerous studies have revealed relationships between its deficiency and occurrence of diverse illnesses, but the question of the proper form and dose of Se-supplementation still remains unsolved. Objective. In the present study the influence of different selenium compounds on blood morphology and biochemistry as well as on phagocytic capacity of granulocytes and NBT test in rats was investigated. Material and methods. Adolescent male Wistar rats were divided into four groups (ten animals each): I – control, received saline; II – received sodium selenite Na2SeO3; III – received selenoorganic compound A of chain structure 4-(o-tolyl-)-selenosemicarbazide of 2-chlorobenzoic acid; IV – received selenoorganic compound B of cyclic structure 3-(2-chlorobenzoylamino-)- 2-(o-tolylimino-)-4-methyl-4-selenazoline. The administration was performed by stomach tube at a dose of 5 · 10-4 mg Se g-1 b.w. once a day for 10 days. Results. Selenium compounds treatment decreased haematocrit. Erythrocytes number was unchanged in all groups receiving Se vs. control, whereas leucocytes number was depressed in groups II and IV. Haemoglobin was significantly decreased in group III. White blood count was altered in groups II and III, where all parameters were markedly decreased except for lymphocytes in group III and remained unchanged in group IV. The outcomes regarding selenium effect on biochemistry parameters of blood showed that urea remained unchanged, glucose was statistically decreased in groups II and III, whereas cholesterol was significantly diminished in group II and increased in group III vs. control. Results concerning phagocytosis and NBT test displayed that % of positive cells were decreased in groups II and III, whereas remained unaltered in group IV vs. control. Conclusions. As cyclic selenoorganic compound B did not cause many significant changes of the studied parameters it may be suggested that after further researches it could be taken into account as a possible selenium supplement.
10
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Influence of the administration of selenium compounds on tissue magnesium concentration in rats

51%
Musik I., Kielczykowska M., Hordyjewska A., Pasternak K.
Journal of Elementology
|
2010
|
tom 15
|
nr 3
539-547
Magnesium and selenium belong to important bioelements. Magnesium is the second most abundant intracellular macroelement, which takes part in the metabolism of carbohydrates, nucleic acids, protein and lipids. Selenium is an essential microelement, whose deficit has been stated in many different pathological states. Much research on safe and effective selenium supplementation has been performed for the last fifty years but the results still remain unsatisfactory. The aim of our study was to investigate the influence of inorganic sodium selenite Na2SeO3 and two selenoorganic compounds synthetized at our chair on magnesium concentration in tissues of adolescent male Wistar rats. Inorganic selenite was administered as a water solution, whereas organic compounds: 4-(o-tolilo)-selenosemikarbazyd of 2-chlorobenzoic acid of a chain structure (ORG-C) and 3-(o-chlorobenzoylamino)-2-(o-tolylimino)-4- -methyl-4-selenazoline of a ring structure (ORG-R) were suspended in emulsion (oil, arabic gum and water). Selenium compounds were given to rats at a dose of 5⋅10–4 mg Se g–1 b.w. once a day for a period of 10 days. The control group was treated with saline. The administration was performed with use of a stomach tube. In comparison to the control group, selenium supplementation caused decrease in magnesium concentration in kidney and lung tissues, but did not cause any changes in the brain and heart muscle. In the liver and spleen it was only ring selenazoline that affected magnesium concentration, increasing it in the liver and decreasing in the spleen. In the femoral muscle it was only the selenosemicarbazide chain that exerted the significant effect causing a decrease in Mg concentration vs the control group. Selenium supplementation influences the tissue magnesium concentrations depending on tissue and structure of the supplement. Irrespective of the administered compound, it lowered magnesium in kidneys and lungs but caused no changes in the brain and heart muscle. In the liver, spleen and femoral muscle, alterations in the magnesium concentration were dependent on the provided supplement.
11
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The influence of lithium and/or selenium on plasma amino acids profile in rats

51%
Kielczykowska M., Musik I., Luchowska-Kocot D., Polz-Dacewicz M.
Annals of Agricultural and Environmental Medicine
|
2022
|
tom 29
|
nr 1
12

Effect of organic selenium compounds on the activity of glutathione peroxidase and superoxide dismutase in selected mouse tissues

51%
Musik I., Staroslawska E., Pasternak K.
Bulletin of the Veterinary Institute in Puławy
|
2003
|
tom 47
|
nr 2
13

The influence of oral administration of chosen metals on calcium level in serum and certain tissues of rats

51%
Kielczykowska M., Pasternak K., Musik I., Boguszewska A.
Acta Toxicologica
|
2004
|
tom 12
|
nr 1
14

The influence of different doses of lithium administrated in drinking water on lipid peroxidation and the activity of antioxidant enzymes of rats

45%
Kielczykowska M., Pasternak K., Musik I., Wronska-Tyra J., Hordyjewska A.
Polish Journal of Environmental Studies
|
2006
|
tom 15
|
nr 5
747-751
Lithium compounds are widely employed in medicine. However, both its positive and negative effects have been revealed. We have tried to evaluate the influence of oral administration of different Li2C03 doses for a period of 8 weeks on the elements of antioxidant status in male rats. The activity of two main antioxidant enzymes: glutathione peroxidase (GPx) and superoxide dismutase (SOD) as well as the con­centration of malonyldialdehyde (MDA) - the marker of lipid peroxidation - have been studied. In blood no significant changes of both lipid peroxidation levels and enzyme activity have been found. In tissues enzymes' activities have decreased, significantly in liver (SOD) and kidney (GPx and SOD). No evidence of lithium-induced lipid peroxidation in the tissues has been observed. In the case of brain the Li protective effect against lipid peroxidation has been displayed. In conclusion, the antioxidant status has not been af­fected in blood and suppressed in tissues as a consequence of Li exposure. The tissue of brain has seemed to be the least attacked organ.
15

Wpływ podawania związków selenu o różnej strukturze na parametry oksydacyjne krwi szczurów

45%
Musik I., Donica H., Kielczykowska M., Hordyjewska A., Pasternak K.
Bromatologia i Chemia Toksykologiczna
|
2011
|
tom 44
|
nr 2
16
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Comparison of histological and ultrastructural changes in mice organs after supplementation with inorganic and organic selenium

45%
Tos-Luty S., Obuchowska-Przebirowska D., Latuszynska J., Musik I., Tokarska-Rodak M.
Annals of Agricultural and Environmental Medicine
|
2003
|
tom 10
|
nr 1
Two organic compounds of selenium, 4-o-totyl-selenosemicarbazide p-chlorobenzoic acid (chain compound) produced at the Chemistry Department of the University Medical School in Lublin, and one inorganic compound of sodium IV selenite (Na2SeO3) were used. The preparations were used per os in doses of 1 mg/kg body weight and 0.5 mg/kg body weight. The studies were conducted on female Swiss mice, covering seven groups of animals, i.e. 6 experimental and 1 control. Histopathologic changes were observed in liver, kidney, lung and heart. Ultrastructural changes were observed in liver and kidney. Our studies indicate a dose-dependent effect of selenium on histopathologic and ultrastructural changes. It is possible therefore, that the extent of excess of selenium exerts a greater influence on a cell than the form of supplemented selenium.
17
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Correlations among plasma silicon, magnesium and calcium in patients with knee osteoarthritis - analysis in consideration of gender

39%
Musik I., Kurzepa J., Luchowska-Kocot D., Kocot J., Pazdzior M., Polz-Dacewicz M., Kielczykowska M.
Annals of Agricultural and Environmental Medicine
|
2019
|
tom 26
|
nr 1
18
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Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium

39%
Kielczykowska M., Polz-Dacewicz M., Kopcial E., Mitrus O., Kurzepa J., Marzec Z., Musik I.
Annals of Agricultural and Environmental Medicine
|
2020
|
tom 27
|
nr 1
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