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In vitro and in vivo gene transfer into neural cells using HSV1 and polyethylene imine (PEI)

100%

Tabbaa S., Goulah C., Tran R., Torres G., Horowitz J. M., Bloom D. C., Stachowiak M. K.

Acta Neurobiologiae Experimentalis

1999

tom 59

nr 3

Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors

68%

Tabbaa S., Goulah C., Tran R. K., Lis A., Korody R., Stachowski B., Horowitz J. M., Torres G., Stachowiak E. K., Bloom D. C., Stachowiak M. K.

Folia Morphologica

2000

tom 59

nr 4

Manipulation of gene expression in developing or in mature central nervous systems (CNS) holds a promise for the resolution of many compelling neurobiological questions, including the feasibility of gene therapy to treat diseases of the brain. In this context, a number of viral vectors have been used in recent years to introduce and express genes into the CNS. This article discusses a gene transfer system based on the Herpes Simplex Virus-1 (HSV-1). We describe here the use of non-replicating, non-toxic HSV-1 vector, 8117/43, in a series of studies carried in our joint program. This vector proves further the utility of HSV-1 as a delivery vehicle to a number of distinct sites within the CNS.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Folia Morphologica

2 Bloom D. C.

2 Goulah C.

2 Horowitz J. M.

2 Stachowiak M. K.

2 Tabbaa S.

2 Torres G.

1 Korody R.

1 Lis A.

1 Stachowiak E. K.

1 Stachowski B.

1 Tran R.

1 Tran R. K.

1 2000

1 1999

Wyniki wyszukiwania

In vitro and in vivo gene transfer into neural cells using HSV1 and polyethylene imine (PEI)

Gene transfer into the central nervous system using Herpes Simplex Virus-1 vectors