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Estimation of functional reserves of the body and risk of cardiovascular events in patients with myocardial infarction with comorbid pathology undergoing rehabilitation

100%

Levytska L., Shved M., Korda M.

Health Problems of Civilization

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2019

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tom 13

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nr 3

Background. Cardiovascular diseases are the leading cause of death worldwide. In Ukraine, cardiovascular mortality is 66.7%. Material and methods. We examined 371 patients with myocardial infarction ( MI) with comorbid pathology who had undergone 90 days of rehabilitation. We studied the possibility of quantitative estimation of comorbid pathology, the condition of functional reserves in patients with MI, their connection with clinical markers of reduced exercise tolerance and comorbidity index. Results. We established close correlations between the six-minute walk tests conducted on the 10th, 30th and 90th days of rehabilitation (6MWT10, 6MWT30 and 6MWT90) with age of patients (r6MWT10 = -0.199; r6MWT30 = -0.287; r6MWT90 = -0.410 P < 0.05), SpO₂ (r6MWT10 = -0.399; r6MWT30 = -0.265; r6MWT90 = -0.248; P < 0.05), left ventricular ejection fraction (r6MWT10 = 0.706; r6MWT30 = -0.670; r6MWT90 = -0.583; P < 0.0001), troponin levels (r6MWT10 = -0.210; r6MWT30 = -0.312; P < 0.05); creatinine (r6MWT10 = -0.148; P < 0,05) and Charlson comorbidity index (r6MWT10 = -0.323; r6MWT30 = -0.398; r6MWT90 = -0.427; P < 0.0001). Conclusions. Markers of reduced exercise tolerance in patients with MI were age, SpO₂, ejection fraction, levels of troponin, creatinine, lymphocytes, Charlson comorbidity index.

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Optimized upstream therapy for managing patients with postinfarction cardiosclerosis associated with hyperuricemia

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Lypovetska S., Prokopovich O., Shved M., Boyko T.

Health Problems of Civilization

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2017

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tom 11

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nr 2

Background. The recent epidemiological studies have shown that serum uric acid (SUA) is a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. Material and methods. 147 patients, (59.2±0.8) years old, with postinfarction cardiosclerosis were included in this study. An evaluation of cardiohemodynamics, heart rhythm disturbances, lipid and purine metabolism’s violation and systemic inflammation was performed before treatment and six months afterwards. Results. An elevated SUA level was associated with the progression of postinfarction heart remodeling. Heterogenity of ventricular repolarization, decrease of heart rate variability, as well as high grade premature ventricular complexes were observed in these patients. Complex treatment with eprosartan provided a significant regress of left ventricle hypertrophy, achievement of target blood pressure levels, complete recovery from ventricular tachycardia, prevention of new-onset of atrial fibrillation. The use of fenofibrate resulted in reducing of total cholesterol, triglycerides, low density lipoproteins, SUA and main markers of systemic inflammation as well as an increase high density lipoproteins. Conclusions. The use of eprosartan and fenofibrate is an optimized upstream strategy for managing patients with postinfarction cardiosclerosis associated with hyperuricemia

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Efficiency of bioflavonoid quercetin and RNA-containing drug sodium nucleinat in complex treatment of patients with myocardial infarction and functional liver disorders

88%

Shved M., Prokopovych O., Lypovetska S., Heryak S., Kitsak Y.

Health Problems of Civilization

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2017

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tom 11

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nr 4

Background. The study has shown that functional liver disorders develop in patients with MI, which requires correction. Material and methods. The study involved 149 patients with acute MI. All examinations were repeated several times on the 1, 14 and 28 day of the treatment. Results. The patients with functional liver disorders have a higher incidence of epistenocardial pericarditis, arrhythmia and systolic dysfunction. They are characterised by highly activated lipid peroxidation and immunological disorders. A combined therapy with quercetin resulted in improving hemodynamics and reducing the manifestations of liver dysfunction. RNAcontaining drug significantly improved the immune status and reduced signs of immunoinflammatory syndromes. Conclusions. 1.In patients with MI and functional liver disorders, the primary pathological process is characterised by significant violations of systolic and diastolic function of the heart, more frequent development of complications, activation of lipid peroxidation and secondary immunodeficiency. 2. The inclusion of bioflavonoid quercetin in the treatment of patients with MI helps to restore the antioxidant defence system, improve myocardial contractile function and reduce clinical laboratory manifestations of cytolytic and cholestatic syndromes in patients due to antioxidant and membrane stabilizing properties of the drug. 3. The usage of the RNA-containing drug Nuclex improves immune reactivity, reduces symptoms of expressed mesenchymal-inflammatory and necro-resorptive syndromes in patients with MI and functional liver disorders.

Ograniczanie wyników

3 Health Problems of Civilization

3 Shved M.

2 Lypovetska S.

1 Boyko T.

1 Heryak S.

1 Kitsak Y.

1 Korda M.

1 Levytska L.

1 Prokopovich O.

1 Prokopovych O.

1 2019

2 2017

Estimation of functional reserves of the body and risk of cardiovascular events in patients with myocardial infarction with comorbid pathology undergoing rehabilitation

Optimized upstream therapy for managing patients with postinfarction cardiosclerosis associated with hyperuricemia

Efficiency of bioflavonoid quercetin and RNA-containing drug sodium nucleinat in complex treatment of patients with myocardial infarction and functional liver disorders