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In the years from 1961-1963, 330 women with vaginal trichomonadosis were treated with the following drugs: tritheon, trichomycin, flagyl, aminitrozol and furovag. The immediate examinations were carried out 7-10 days after the treatment and the evaluation of remote results 3-6 months later. Tritheon (Ortho) was used in 30 women along with acetarsol globules. The early control examinations showed the cure percentage of 53.3%, the remote ones - of 33.3%. Aminitrozol (Polfa) was administered by oral route in women and men along with acetarsol globule; 30 couples were treated. The cure percentage established by immediate examlnation was 40%, that by remote one – 30%. Furovag (Pharmaceutical Institute) was used only topically in intravaginal globules. Among 50 women treated the remote follow-up examination showed the cure percentage of 26%. Trichomycin was applied orally and intravaginally in women of the first group with parallel treatment of men and only intravaginally in the second group: the remote follow-up examination revealed the curative effect of 42.4% in the first and of 30% in the second group. Flagyl (Specia) was administered by oral and intravaginal route in 110 women. The remote results showed the curative effect in 81.8% of cases, with topical use of the drug in 48.8%. The treatment of trichomonadosis should be concerned with both sexual partners. The greatest therapeutic effect was exhibited by flagyl: 81.8% of cures.
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Flagyl was used in 110 women with acute and chronic trichomonadosis of the vagina in women; the treatment also included the sexual partners. The drug was administered by oral route in the dosis of 0.25 2 X daily and intravaginally 1 X 0.5 for 1.0 days. The examination carried out 10 days after the treatment showed the disappearance of T. vaginalis in 100%. The follow-up control 1/2 year later revealed positive results in 88.l%. Flagyl proved to be the most efficient drug among the hitherto applied antitrichomonal compounds.
Furovag (furazolidone-N-5 Nitro-2-furfulidene 3-amino 2-oxazolide) was used to treat vaginal trichomonadosis in 50 women; the drug was administered for 6 days in the amount of 2 dragees and then for 8 days 1 dragée daily. A complete subsidence of the disease symptoms was found in 40% of cases. The follow- up examinination 4 weeks later showed the curative effect of the drug in 26%.
The authrs examined the oviducts of women treated operatively in the IInd Clinic of Obstetrics and Gynecology, Medical School, Gdańsk, who exhibited a long-standing trichornonadosis, for the presence of T. vaginaiis. During the gynecologic operation, the oviducts were removed and placed on the Pawłowa medium wilh the incubalion at 37°; after 48 hours the fluid was centrifuged, the sediment placed on another medium and examined under microscope. The oviduct was flushed with buffor used for Pawłowa medium, precipitated, and centrifuged, transferring the sediment on Pawłowa medium. The cultures were checked after 24,48 and 72 hours. Among 4 women, in whom oviduct cultures were made, 2 showed positive results. In one case an isolated strain could be maintained through several passages, in the other, single degenerated, poorly motile forms of the protozoon were found after 24 hours, which disappeared completely in the next passages.
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