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Kardiotoksyczność doksorubicyny

100%

Staszczyk M., Paslawska U., Hildebrand W., Rybinska I., Cepiel A.

Życie Weterynaryjne

2013

tom 88

nr 02

Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium

58%

Kiczak L., Tomaszek A., Bania J., Paslawska U., Zacharski M., Janiszewski A., Rybinska I., Dziegiel P., von Haehling S., Ardehali H., Jankowska E. A., Ponikowski P.

Journal of Physiology and Pharmacology

2014

tom 65

nr 3

P-R interval in porcine model of chronic tachycardia-induced cardiomyopathy

58%

Skrzypczak P., Zysko D., Paslawska U., Noszczyk-Nowak A., Janiszewski A., Kiczak L., Bania J., Zacharski M., Tomaszek A., Rybinska I., Nicpon J., Paslawski R., Gajek J., Jankowska E. A., Ponikowski P.

Bulletin of the Veterinary Institute in Puławy

2013

tom 57

nr 3

The aim of the study was to assess the atrioventricular conduction in the model of porcine pacing induced tachycardiomyopathy. Fifty-one swine were examined: 27 were paced and 24 served as a control group. Every 4 weeks, the animals were anaesthetised for 1 h and an ECG Holter was performed. Thirty minutes after the onset of anaesthesia, P-R and R-R intervals were measured. Each result was assigned to the subgroup according to the animal's weight and the presence or absence of previous pacing. P-R interval was longer in animals after at least 4 weeks of rapid ventricular stimulation than in adjusted group of the animals according to the body mass. Multivariate analysis has showed that longer P-R interval was related to male gender, higher body mass, slower heart rate, and history of previous pacing. Chronic ventricular pacing led to the slowing of atrioventricular conduction. The presence of differences in the duration of R-R intervals between groups was only found in swine weighing 120-139 kg. The R-R interval was shorter in paced animals, whereas PR interval was longer in that group, indicating that PR prolongation is related to electrical or structural remodelling of the cardiac conductive tissue but not increased sympathetic nervous system activity, which is expected to produce corresponding changes in PR and R-R intervals.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Journal of Physiology and Pharmacology

1 Życie Weterynaryjne

3 Paslawska U.

3 Rybinska I.

2 Bania J.

2 Janiszewski A.

2 Jankowska E. A.

2 Kiczak L.

2 Ponikowski P.

2 Tomaszek A.

2 Zacharski M.

1 Ardehali H.

1 Cepiel A.

1 Dziegiel P.

1 Gajek J.

1 Hildebrand W.

1 Nicpon J.

1 Noszczyk-Nowak A.

1 Paslawski R.

1 Skrzypczak P.

1 Staszczyk M.

1 Zysko D.

1 von Haehling S.

1 2014

2 2013

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Kardiotoksyczność doksorubicyny

Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium

P-R interval in porcine model of chronic tachycardia-induced cardiomyopathy