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DNA repair in cancer initiation, progression, and therapy - a double-edged sword

100%

Kiwerska K., Szyfter K.

Journal of Applied Genetics

2019

tom 60

nr 3-4

Single nucleotide polymorphism rs11614913 associated with CC genotype in miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not salivary gland tumors in Polish population

51%

Skalski M., Ustaszewski A., Jaskiewicz K., Kiwerska K., Wierzbicka M., Klimza H., Grenman R., Giefing M.

Journal of Applied Genetics

2018

tom 59

nr 3

Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck

37%

Hartmann S., Szaumkessel M., Salaverria I., Simon R., Sauter G., Kiwerska K., Gawecki W., Bodnar M., Marszalek A., Richter J., Brauze D., Zemke N., Jarmuz M., Hansmann M.-L., Siebert R., Szyfter K., Giefing M.

Journal of Applied Genetics

2012

tom 53

nr 2

Although down-regulation of GNG7 in cancer was reported before, its role in carcinogenesis is poorly understood. It belongs to a family of large G-proteins that may be involved in cell-contact-induced growth arrest and function in tumor suppression. In the present study, we stained immunohistochemically 188 tumors derived from larynx or floor of the mouth for GNG7 protein and confronted it with clinicopathologic data. Moreover, we performed bisulfite pyrosequencing to analyze GNG7 promoter methylation. We identified recurrent loss of GNG7 protein expression in 68/188 (36%) cases and promoter hypermethylation in (42/98; 43%) primary tumors, predominantly in young patients (p<0.001). Loss of GNG7 expression correlated with hypermethylation of GNG7 promoter region (p<0.001). Moreover, loss of GNG7 protein expression correlated with tumor size (p=0.012) and lack of cervical metastasis (p=0.02) whereas sustained expression correlated with keratinization (p=0.008). Taken together, loss of GNG7 protein expression is a frequent event in head and neck cancer. Moreover, our data suggest that hypermethylation of the promoter region of GNG7 is probably the mechanism of the observed inactivation.

Ograniczanie wyników

3 Journal of Applied Genetics

3 Kiwerska K.

2 Giefing M.

2 Szyfter K.

1 Bodnar M.

1 Brauze D.

1 Gawecki W.

1 Grenman R.

1 Hansmann M.-L.

1 Hartmann S.

1 Jarmuz M.

1 Jaskiewicz K.

1 Klimza H.

1 Marszalek A.

1 Richter J.

1 Salaverria I.

1 Sauter G.

1 Siebert R.

1 Simon R.

1 Skalski M.

1 Szaumkessel M.

1 Ustaszewski A.

1 Wierzbicka M.

1 Zemke N.

1 2019

1 2018

1 2012

Wyniki wyszukiwania

DNA repair in cancer initiation, progression, and therapy - a double-edged sword

Single nucleotide polymorphism rs11614913 associated with CC genotype in miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not salivary gland tumors in Polish population

Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck