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1

Kwercetyna w terapii przeciwnowotworowej

100%
Jakubowicz-Gil J.
Postępy Biologii Komórki
|
2012
|
tom 39
|
nr 2
2

Inhibitory szlaku PI3K-Akt-PKB-mTOR w leczeniu glejakow

100%
Jakubowicz-Gil J.
Postępy Biologii Komórki
|
2009
|
tom 36
|
nr 2
189-201
3

Rozmieszczenie i rola bialek szoku termicznego w komorce zwierzecej.

63%
Jakubowicz-Gil J., Gawron A.
Postępy Biologii Komórki
|
1999
|
tom 26
|
nr 2
267-283
4

Occurance of poly (ADP-ribose) polymerase in Phaseolus coccineus (L.) plants exposed to cadmium

51%
Patrzylas P., Pawlikowska-Pawlega B., Jakubowicz-Gil J., Skorzynska-Polit E.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2009
|
tom 51
|
nr 2
5

The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells

51%
Jakubowicz-Gil J., Paduch R., Gawron A., Kandefer-Szerszen M.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 1
6

The effect of quercetin on apoptosis and necrosis induction in human colon adenocarcinoma cell line LS180

51%
Pawlikowska-Pawlega B., Jakubowicz-Gil J., Rzymowska J., Gawron A.
Folia Histochemica et Cytobiologica
|
2001
|
tom 39
|
nr 2
7

The effect of quercetin on the expression of heat shock proteins and apoptosis induction in monkey kidney cell line GMK

51%
Jakubowicz-Gil J., Rzymowska J., Paduch R., Gawron A.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
8

Cell death and neuronal arborization upon quercetin treatment in rat neurons

45%
Jakubowicz-Gil J., Rzeski W., Zdzisinska B., Dobrowolski P., Gawron A.
Acta Neurobiologiae Experimentalis
|
2008
|
tom 68
|
nr 2
Quercetin, one of the major flavonoids, exhibits many beneficial effects on human organism as antihistamine, antioxidant, anti-inflammatory, anticancer and antiviral drug. It is recommended as suplement of healthy diet but still the knowledge of its beneficial effect on normal cells is not satisfactory. We decided to examine the effect of flavonoid on neurons morphology and their susceptibility to cell death. Fractal analysis of rat neurons revealed that 24 hours long incubation with quercetin diminished neuronal arborisation in cortical neurons. Neurons also appeared to be very sensitive to cell death after flavonoid treatment in concentration dependent manner. Over 50% of cells died after incubation with 15 μg/ml of flavonoid while 1 μg/ ml of quercetin induced cell death only in 5%. Staining with Hoechst 33342 and propidium ioidide revealed the two types of cell death: apoptosis and necrosis. The number of apoptotic cells was comparable with necrotic ones. These results suggest toxic effect of quercetin on neurons what should be taken into consideration in further studies on using quercetin as therapeutic agent.
9

Wplyw furanokumaryn peucedaniny i bergaptenu, izolowanych z owocow Peucedanum tauricum Bieb. [Apiaceae] na indukcje apoptozy i ekspresje bialek szoku termicznego w komorkach HeLa

45%
Bartnik M., Glowniak K., Jakubowicz-Gil J., Pawlikowska-Pawlega B., Gawron A.
Herba Polonica
|
2006
|
tom 52
|
nr 3
58-59
10

Apoptotic cells as a diagnostic factor in breast cancer patients

45%
Rzymowska J., Jakubowicz-Gil J., Piersiak T., Grzybowska-Szatkowska L., Gawron A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
11

Effect of peucedanin and bergapten [5-MOP], furanocoumarins isolated from Peucedanum tauricum Bieb. [Apiaceae] fruits, on apoptosis induction and heat-shock protein expression in HeLa cells

45%
Bartnik M., Glowniak K., Jakubowicz-Gil J., Pawlikowska-Pawlega B., Gawron A.
Herba Polonica
|
2006
|
tom 52
|
nr 4
The optimal times for the extraction of potato cuticular waxes with dichloromethane were established for three classes of compounds, namely 40 sec for alcohols and fatty acids, and 60 sec for alkanes, which is sufficient to isolate at least ca. 90% of wax components. A two-step extraction using two consecutive portions of a solvent ensured better recovery (ca. 94%) than a one-step procedure (49V60ÜS).
12

Quercetin suppresses heat shock-induced nuclear translocation of Hsp72

45%
Jakubowicz-Gil J., Pawlikowska-Pawlega B., Piersiak T., Pawelec J., Gawron A.
Folia Histochemica et Cytobiologica
|
2005
|
tom 43
|
nr 3
13

The effect of quercetin on induction of apoptosis

45%
Rzymowska J., Gawron A., Pawlikowska-Pawlega B., Jakubowicz-Gil J., Wojcierowski J.
Folia Histochemica et Cytobiologica
|
1999
|
tom 37
|
nr 2
14

Different sensitivity of neurons and neuroblastoma cells to quercetin treatment

39%
Jakubowicz-Gil J., Rzeski W., Zdzisinska B., Piersiak T., Weiksza K., Glowniak K., Gawron A.
Acta Neurobiologiae Experimentalis
|
2008
|
tom 68
|
nr 4
Quercetin is a natural flavonoid with pro-apoptotic and antiproliferative properties. In this study, we determined the sensitivity of neurons and neuroblastoma cells on apoptosis and necrosis induction upon quercetin treatment. No expression of Hsp72 was observed in neurons, which were more sensitive to cell death upon quercetin treatment than neuroblastoma cells, where Hsp72 expression was observed. Reduction of Hsp72 gene expression in neuroblastoma cells by antisense oligonucleotides made them more sensitive to pro-apoptotic action of quercetin. Moreover, the flavonoid decreased Hsp27, procaspase-3, MRP and PKB expression in neuroblastoma cells and in neurons. Nuclear localization of mainly cytoplasmic Hsp27 was observed in neuroblastoma cells after treatment with high quercetin concentrations, while in neurons, the protein was present in nuclei both in control and quercetin treated cells. Our results suggest that quercetin induce apoptosis more effectively in cells with low level of Hsp 72 expression. Higher sensitivity of neurons for cell death after treatment with high quercetin concentrations in comparison to neuroblastoma cell line should also be taken into consideration in further studies on using studied flavonoid as therapeutic agent.
15

Cell death in HeLa cells upon imperatorin and cisplatin treatment

39%
Jakubowicz-Gil J., Paduch R., Ulz Z., Badziul D., Glowniak K., Gawron A.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 3
16

Regulation of folliculogenesis by growth factors in piglet ovary exposed prenatally to beta-hydroxy-beta-methylbutyrate (HMB)

39%
Hulas-Stasiak M., Jakubowicz-Gil J., Dobrowolski P., Grzesiak M., Muszynski S., Swiatkiewicz M., Tomaszewska E.
Annals of Animal Science
|
2020
|
tom 20
|
nr 3
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