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The influence of heterocyclic compound - PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

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Potkin V. I., Shcharbin D., Denisov A. A., Paschkevich S. G., Bryszewska M., Petkevich S. K., Kletskov A. V., Lapotko D. O., Kazbanov V. V., Gurinovich T. A., Kulchitsky V. A.

Cellular and Molecular Biology Letters

2014

tom 19

nr 2

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Bryszewska M.

1 Denisov A. A.

1 Gurinovich T. A.

1 Kazbanov V. V.

1 Kletskov A. V.

1 Kulchitsky V. A.

1 Lapotko D. O.

1 Paschkevich S. G.

1 Petkevich S. K.

1 Potkin V. I.

1 Shcharbin D.

1 2014

Wyniki wyszukiwania

The influence of heterocyclic compound - PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue