Wyniki wyszukiwania

1

Rola desaturazy stearoilo-CoA w utrzymaniu homeostazy metabolicznej

100%

Dobrzyn P.

Postępy Biochemii

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2012

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tom 58

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nr 2

2

Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation

63%

Dobrzyn A., Dobrzyn P.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 10

31-42

Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are a major component of tissue lipids. SCD1 deficient mice reveal increased energy expenditure and decreased body adiposity due to the upregulation of genes of fatty acid oxidation and the downregulation of genes of lipid synthesis in liver. In this review, we examine data showing that SCD is an important component in the regulation of skeletal muscle metabolism, which affects insulin sensitivity, mitochondrial fatty acid oxidation and ceramide de novo synthesis in oxidative myofibers. The lack of SCD1 gene increases the rate of fatty acid ß-oxidation through activation of the AMP-activated protein kinase (AMPK) pathway and by upregulating genes of fatty acid oxidation in soleus and red gastrocnemius muscles. Consistent with increased ß-oxidation, the contents of free fatty acids and long-chain acyl-CoAs are significantly decreased, which together with reduced mRNA level and activity of serine palmitoyltransferase led to reduced ceramide synthesis in oxidative muscles of SCD1-/- mice. Thus, reduced contents of free fatty acids, acyl-CoAs and ceramides as well as increased AMPK phosphorylation, might contribute to increased insulin sensitivity observed in muscle of SCD1-/- mice. SCD1 deficiency also results in downregulation of the expression of the protein-tyrosine phosphatase 1B, which is responsible for the sustained insulin receptor autophosphorylation despite reduced levels of plasma insulin in the SCD1-/- mice. SCD1 deficiency reduced ceramide synthesis, increased AMPK phosphorylation and carnitine palmitoyltransferase 1 activity also in soleus and red gastrocnemius muscles of leptin deficient ob/ob mice. These findings raise the possibility that SCD1 may be a downstream component of the leptin signaling pathway in skeletal muscle.

3

The role of stearoyl-CoA disaturase 1 in cardiac lipid accumulation

51%

Dobrzyn P., Dobrzyn A., Ntambi J. M.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

4

Regulacja transkrypcji genów przez długołańcuchowe kwasy tłuszczowe

51%

Jazurek M., Dobrzyn P., Dobrzyn A.

Postępy Biochemii

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2008

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tom 54

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nr 3

5

Stearoyl-CoA desaturase 1 deficiency decreases fatty acid oxidation in the heart

51%

Dobrzyn P., Dobrzyn A., Ntambi J.-M.

Acta Biochimica Polonica

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2007

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tom 54

|

nr Supplement 4

6

The effect of auxins and salicylic acid on chlorophyll and carotenoid contents in Wolffia arrhiza [L.} Wimm. [Lemnaceae] growing on media of various trophicities

51%

Czerpak R., Dobrzyn P., Krotke A., Kicinska E.

Polish Journal of Environmental Studies

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2002

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tom 11

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nr 3

In Wolffia arrhiza {Lemnaceae) growing on municipal tap water (rich in mineral but poor in organic components) and thus being exclusively photoautotrophic, IAA (3-indolilacetic acid) and SA (salicylic acid) strongly stimulated action on the content of chlorophylls a and b and carotenoids (especially β-carotene and lutein + zeaxanthin). On the other hand, the chemical analogues of IAA, i.e. PAA (phenylacetic acid) and NAA (α-naphtylacetic acid), had a generally inhibitory effect on chlorophyll and carotenoid contents. In Wolffia arrhiza growing on raw waste water and a suspension of activated sludge from a sewage treatmentplant (rich in organic substances) characterized by mixotrophism (that is photo- and heterotrophism) PAA had the highest stimulative action on the chlorophyll a and b content, SA negligible, whereas NAA had an inhibitory effect. IAA had a slight stimulative effect on raw sewage but inhibitory on activated sludge. Also, the greatest stimulative effect on carotenoids content was exerted by PAA; SA had a slight stimulative effect while IAA and, to a greater extent NAA had a clearly inhibitory influence.

7

The effect of thiamine and oxythiamine on the rate of growth of Saccharomyces cerevisiae in vitro culture

45%

Tylicki A., Dobrzyn P., Czerniecki J., Lempicka A., Romaniuk-Demonchaux K.

Cellular and Molecular Biology Letters

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2001

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tom 06

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nr 3A

769

8

The effect of biochanin A on the chlorophylls and carotenoids content in the alga Chlorella vulgaris Beijerinck

45%

Czerpak R., Piotrowska A., Dobrzyn P., Tatur A., Marczuk M.

Acta Physiologiae Plantarum

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2003

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tom 25

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nr 3

9

Puruvate and 2-oxoglutarate dehydrogenases as the essential regulatory points of metabolism

39%

Czerniecki J., Dobrzyn P., Tylicki A., Kondracikowska J., Czygier M., Strumilo S.

Acta Biochimica Polonica

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2006

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tom 53

|

nr Supplement 1

Ograniczanie wyników

Rola desaturazy stearoilo-CoA w utrzymaniu homeostazy metabolicznej

Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation

The role of stearoyl-CoA disaturase 1 in cardiac lipid accumulation

Regulacja transkrypcji genów przez długołańcuchowe kwasy tłuszczowe

Stearoyl-CoA desaturase 1 deficiency decreases fatty acid oxidation in the heart

The effect of auxins and salicylic acid on chlorophyll and carotenoid contents in Wolffia arrhiza [L.} Wimm. [Lemnaceae] growing on media of various trophicities

The effect of thiamine and oxythiamine on the rate of growth of Saccharomyces cerevisiae in vitro culture

The effect of biochanin A on the chlorophylls and carotenoids content in the alga Chlorella vulgaris Beijerinck

Puruvate and 2-oxoglutarate dehydrogenases as the essential regulatory points of metabolism