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Morphology of the dorsal nasal, frontal and facial veins in adult gilts

100%

Zezula-Szpyra A., Grzegorzewski W.

Folia Morphologica

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2000

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tom 59

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nr 3

Morphological examinations conducted on adult gilts indicate that the dorsal nasal, frontal and facial veins belong to the myoelastic type with a well-developed internal elastic lamina and a thick tunica media with elastic fibers. Smooth muscle cells in the tunica media are mainly arranged circularly. A characteristic feature of individual veins, and even their parts, was the difference in the distribution and number of elastic fibers and amount of collagen, both in the internal elastic lamina and tunica media. Slight thickening of the vessel walls and a decrease in the number of elastic fibers were observed in the distal part of the dorsal nasal vein and in the proximal parts of the frontal and facial veins. No valves were found in the frontal vein. The bundles of smooth muscle cells in the tunica media and elastic fibers surrounding them were rounded, not laminar like in the other veins. Characteristic, sandwich-like arranged smooth muscle bundles, elastic fibers and large amounts of collagen were observed in the tunica media of the distal part of the facial vein. A distinctive feature of the middle auricular and radial veins was the presence of a well-visible external elastic lamina in the adventitia. An evaluation of the luminous vein surface in a SEM shows that endothelial cells are elongated and arranged consistently with the direction of blood flow in almost all of the veins analyzed. Endothelial cells were less elongated in the distal part of the facial vein, and microvilli were present on them.

2

Local vascular pathway for progesterone transfer to the brain after nasal administration in gilts

81%

Skipor J., Grzegorzewski W., Einer-Jensen N., Wasowska B.

Reproductive Biology

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2003

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tom 03

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nr 2

3

Retrograde transfer of 125I-radiolabelled activin and inhibin in the periovarian vascular complex in the sow

81%

Wasowska B., Stefanczyk-Krzymowska S., Grzegorzewski W.

Polish Journal of Veterinary Sciences

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2009

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tom 12

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nr 2

159-167

This study investigated whether activin A and an inhibin-a subunit fragment (INHα) could permeate in a periovarian vascular complex from ovarian effluent into the ovarian artery and be retrograde transferred into the ovary. Radiolabelled activin A (125I-activin A) and INHα (125I-INHα) were injected (2.7xl07 dpm) into follicles or corpora lutea (CL). It was demonstrated that 125I-activin A and 125I-INHa were released into the ovarian effluent and permeated into the arterial blood supplying the ovary in both phases of the cycle. The concentration of 125I-activin A in ovarian arterial blood was higher in the luteal phase (LP) than in the follicular phase (FP) (P<0.0001) in contrast to 125I-INHα which was higher in the FP (P<0.0001). The concentration of 125I-activin A in uterine tissues generally did not differ between the phases of the estrous cycle, but the concentration of 125I-INHα was higher (P<0.05) in the FP than in the LP. The concentration of 125I-activin A was higher in the LP in samples of endometrium and myometrium (P<0.05), as well as mesometrium (P<0.01), and higher in the FP in samples of mesometrium (P<0.05) close to the ovary than in the samples adjoining the uterine body. In the FP, the concentration of 125I-INHa was higher in endometrium and mesometrium close to the ovary than in samples adjoining the uterine body (P<0.05). In conclusion, the study demonstrated that it was possible for INHa and activin A to be retrograde transferred to the ovary. Thus this transfer could elevate their concentration in arterial blood supplied to the ovarian follicles or CL and may influence production of these peptides in the ovary, modulating ovarian function.

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Luteinizing hormone and prolactin are not retrograde transferred in perihypophyseal vascular complex in ewes

81%

Skipor J., Grzegorzewski W., Wasowska B., Krzymowski T.

Reproductive Biology

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2004

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tom 04

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nr 2

5

Effect of unilateral ovariectomy on counter-current transfer of prostaglandin F2alpha in the area of mesometrium vasculature in the pig

81%

Stefanczyk-Krzymowska S., Grzegorzewski W., Skipor J., Krzymowski T.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1992

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tom 40

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nr 1

6

Local transport of testosterone from the nasal mucosa to the carotid blood and the brain in the pig

81%

Skipor J., Grzegorzewski W., Krzymowski T., Einer-Jensen N.

Polish Journal of Veterinary Sciences

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2000

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tom 03

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nr 1

Local counter current transfer of substances between venous and arterial vessels has been found in the perihypophyseal vascular complex after administration into the supraorbital vein. The present experiments investigate whether similar transfer could be found after nasal administration of testosterone. Experiments were conducted on the model of isolated pig's head perfused with autologous blood through one carotid artery. Tritium labelled testosterone was infused onto the nasal mucous. Radioactivity was measured in blood samples collected from the contralateral carotid artery (indicator of transfer), in the venous effluent from the jugular veins (indicator of absorption), and in tissue samples from the olfactory bulb, olfactory triangle, hypothalamus, mammillary body, cortex, pons, cerebellum, neurohypophysis, adenohypophysis, pia vessels and perihypophyseal vascular complex. The absorption was 11.4 ±4.6 per cent (mean ± SEM) and 0.4 ±0.3 per cent of the instilled testosterone was transferred during the 25 min collection period. The uptake of radioactivity was seen in many of the brain tissue samples representing the brain, pituitary, pia vessels and cavernous sinus - carotid rete complex, although a clear pattern was not seen. Nasally administered drugs may thus reach the brain in a relatively higher concentration than it reaches the rest of the body. This makes targeted treatment of the brain a distinct possibility. Additionally, the treatment will decrease the first-passage metabolism in the liver.

7

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Evaluation of the time-stability of aortic rings in young Wistar rats during an eight-hour incubation period

61%

Majewski M., Lepczynska M., Dzika E., Grzegorzewski W., Markiewicz W., Mendel M., Chlopecka M.

Journal of Elementology

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2019

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tom 24

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nr 2

8

The effect of lateral electrical surface stimulation (LESS) on motor end-plates in an animal model of experimental scoliosis

42%

Wojtkiewicz J., Kowalski I. M., Kmiec Z., Crayton R., Babinska I., Bladowski M., Szarek J., Kiebzak W., Majewski M., Barczewska M., Grzegorzewski W., Kloc W.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 3

Ograniczanie wyników

Morphology of the dorsal nasal, frontal and facial veins in adult gilts

Local vascular pathway for progesterone transfer to the brain after nasal administration in gilts

Retrograde transfer of 125I-radiolabelled activin and inhibin in the periovarian vascular complex in the sow

Luteinizing hormone and prolactin are not retrograde transferred in perihypophyseal vascular complex in ewes

Effect of unilateral ovariectomy on counter-current transfer of prostaglandin F2alpha in the area of mesometrium vasculature in the pig

Local transport of testosterone from the nasal mucosa to the carotid blood and the brain in the pig

Evaluation of the time-stability of aortic rings in young Wistar rats during an eight-hour incubation period

The effect of lateral electrical surface stimulation (LESS) on motor end-plates in an animal model of experimental scoliosis