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1

Polymorphism of genes coding for proteins involved in DNA repair is colon cancer morbidity factor

100%
Gdowicz-Klosok A., Klosok M., Widel M., Widel M., Olinski R., Rzeszowska-Wolny J.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
2

Identification of genes important in modulation of radiosensibility of human melonoma cells

94%
Herok R., Fujarewicz K., Widel M., Rzeszowska-Wolny J.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
3

Polymorphism of DNA repair genes as a cancer risk factor; comparison between head and neck squamous cell carcinoma and colon cancer

84%
Jelonek K., Gdowicz-Klosok A., Pietrowska M.-A., Widel M., Zeman M., Kryj M., Widel M., Rzeszowska-Wolny J., Grzywna Z., Widlak P.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
4

Comparison of DNA damage and repair kinetics in lymphocytes of cancer patients and healthy donors

83%
Lubecka B., Widel M., Kolosza Z., Jedrus S., Rzeszowska J.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
5

Apoptosis and clonogenic survival in three tumour cell lines exposed to gamma rays or chemical genotoxic agents

83%
Kumala S., Niemiec P., Widel M., Hancock R., Rzeszowska-Wolny J.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 3
We compared the extent to which apoptosis is induced and clonogenicity reduced in three tumour cell lines - the human melanoma Me45 and promyelocytic leukaemia HL-60, and the rat rhabdomyosarcoma R1 - after exposure to the anticancer drugs etoposide and cis-platinum or to gamma radiation; each induces different types of DNA damage. Cells which readily underwent apoptosis did not necessarily show a correlated loss of clonogenicity; for example, Me45 cells showed the highest sensitivity to all three agents in clonogenic assays but much lower levels of apoptotic cells than R1 or HL-60 cells. These results show that the efficiency of the eradication of clonogenic cells by genotoxic agents does not solely depend on the induction of apoptotic processes, and suggest that the induction of apoptosis and suppression of clonogenicity are independent processes.
6

Wpływ holoksanu na wzrost hodowli megakolonii raka płaskonabłonkowego in vitro

72%
Polaniak R., Birkner E., Kasperczyk A., Widel M., Kasperczyk S., Grucka-Mamczar E.
Diagnostyka Laboratoryjna
|
2001
|
tom 37
|
nr 3
7

Influence of vitamin E and extremely low frequency magnetic field on the activity of lactase dehydrogenase of squamous cell carcinoma cells in vitro

72%
Polaniak R., Birkner E., Widel M., Przybyszewski W., Goliszewska M., Filipowska B., Grucka-Mamczar E.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
8

Radiotoxic effects of cancer cells irradiated in vitro on neighbour nonirradiated cells

72%
Poloniak R., Szurko A., Widel M., Maniakowski Z., Birkner E., Przybyszewski W.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
9

Oxidative damage, DNA repair capacity and DNA repair gene polymorphisms and colon cancer

72%
Rzeszowska-Wolny J., Widel M., Olinski R.-S., Gdowicz A., Polanska J., Puszynski K., Tudek B.-A.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
10

Photodynamic effects of two water soluble porphyrins evaluated on human malignant melanoma cells in vitro

72%
Szurko A., Kramer-Marek G., Widel M., Ratuszna A., Habdas J., Kus P.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 4
Two water soluble porphyrins: meso-tetra-4-N-methylpyridyl-porphyrin iodide (P1) and 5,10-di-(4-acetamidophenyl)-15,20-di-(4-N-methylpyridyl) porphyrin (P2) were synthesised and evaluated in respect to their photochemical and photophysical properties as well as biological activity. Cytotoxic and phototoxic effects were evaluated in human malignant melanoma Me45 line using clonogenic assay, cytological study of micronuclei, apoptosis and necrosis frequency and inhibition of growth of megacolonies. Both porphyrins were characterised by high UV and low visible light absorptions. Dark toxicity measured on the basis of the clonogenic assay and inhibition of megacolony growth area indicated that P1 was non-toxic at concentrations up to 50 ug/ml (42.14 uM) and P2 at concentrations up to 20 ug/ml (16.86 uM). The photodynamic effect induced by red light above 630 nm indicated that both porphyrins were able to inhibit growth of melanoma megacolonies at non-toxic concentrations. Cytologic examination showed that the predominant mode of cell death was necrosis.
11

Analyses of lymphocyte radiosensitivity in vitro for identification of predictive biomarkers of early response to radiotherapy in head and neck cancer patients

60%
Pietrowska M.-A., Walaszczyk A.-J., Palyvoda O., Widel M., Wygoda A., Rutkowski T., Hutnik M., Skladowsk K., Polanska J., Rzeszowska-Wolny J.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr Supplement 4
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