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1

Increased anxiety-related behavior in a zebrafish model of Tuberous sclerosis complex recapitulated human symptoms of the disease

100%
Kedra M.
Acta Neurobiologiae Experimentalis
|
2019
|
tom 79
|
nr Suppl.1
INTRODUCTION: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder, caused by mutations inactivating genes for proteins hamartin (TSC1) and tuberin (TSC2) and subsequent overactivation of mTORC1. TSC manifests itself by the presence of hamartomas in various organs, although epilepsy is the most influential in mortality. Not only neurological symptoms but also neuropsychiatric manifestations affect TSC patients, which are gathered by the name TSC-associated Neuropsychiatric Disorders (TANDs). The most common disorders are autism spectrum disorder (25‑50%), intellectual disability (30‑50%), and anxiety (30‑60%). METHOD(S): In our study we used tsc2vu242 zebrafish mutant line in which a truncating mutation in tsc2 gene led to lack of Tsc2 protein. We performed three types of behavioral test towards anxiety: Response to Sudden Light Changes, New Environment Exploration, and the Light preference test. We also measured cortisol levels in 5 dpf tsc2vu242 larvae. RESULTS: In response to the Sudden Light Changes test, tsc2vu242/vu242 mutant fish exhibited stronger freezing and hyperactivity behavior between dark and light phases compared to tsc2+/+ fish, which indicates increased anxiety. In the New Environment Exploration test, tsc2vu242/vu242 mutant fish spent less time exploring the central area of the plate compared to their sibling of other genotypes, choosing safe areas near the edges. Only in the Light Preference test, tsc2vu242/242 fish presented impaired phototaxis, preferring the dark compartment, while tsc2+/+ controls show clear positive phototaxis. Elevated cortisol levels in tsc2vu242/vu242 mutants further confirmed increased anxiety. CONCLUSIONS: We show that tsc2vu242/vu242 fish exhibit increased anxiety-related behavior compared with tsc2+/+ fish, also on the stress hormone level. The Light Preference test points to intellectual disability in the tsc2vu242/vu242 mutant. These results reflect the human phenotype of TANDs.
2

Najwazniejsze skladniki pokarmu zarlacza blekitnego i ostronosa

100%
Kedra M.
Magazyn Przemysłu Rybnego
|
2003
|
nr 1
14-15
3

Zastosowanie metod kultur tkankowych w aktywnej ochronie Saxifraga hirculus L.

100%
Kedra M.
Wiadomości Botaniczne
|
2011
|
tom 55
|
nr 3-4
4

Wybrane zagadnienia biologii populacji zawilca wielkokwiatowego [Anemone sylvestris L.]

100%
Kedra M.
Prądnik. Prace i Materiały Muzeum im. Prof. Wł. Szafera
|
1998
|
tom 11-12
207-218
5

Znaczenie glonow w srodowisku morskim - toksyczne zakwity bruzdnic

88%
Kedra M.
Magazyn Przemysłu Rybnego
|
2001
|
nr 4
16-19
6

AFLP analysis of genetic diversity in natural population and tissue culture plants of Saxifraga hirculus L.

63%
Kedra M., Cieslak E.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2009
|
tom 51
|
nr 2
7

Morphogenesis of Lilium martagon L. explants in callus culture

63%
Kedra M., Bach A.
Acta Biologica Cracoviensia. Series Botanica
|
2005
|
tom 47
|
nr 1
The effect of two plant growth regulators on the initiation of callus and regeneration of L. martagon was studied on modified MS medium. The cultures were initiated using seeds. The explants were isolated from different parts of seedlings (hypocotyls, seedling bulb, root) and adventitious bulblets. The growth regulators stimulated various types of callus. 4-amino-3,5,6-trichloropyridine-2-carboxylic acid (Picloram) induced a yellow, friable, granular callus, whereas benzyladenine (BA) alone induced a cream-white, compact callus. MS medium containing Picloram plus BA stimulated a yellow, compact, granular callus. The most useful explants for callus initiation were seedling bulbs and adventitious bulblet scales. The most efficient embryogenic callus was obtained on MS medium containing 5 µM Picloram and 5 µM BA. Histological studies showed that the embryogenic callus was formed at the epidermal cells and near vascular bundles of explants. Somatic embryos were solitary, whereas adventitious bulblets were closely connected with vascular tissue. No differences in the amount of DNA between scale tissue and callus were observed. Lilium martagon L. is an endangered species in Poland. In vitro culture techniques can play an important role in the future protection of this rare plant species.
8

Somatic embryogenesis of Lilium martagon L. in seedlings culture

63%
Bach A., Kedra M.
Acta Biologica Cracoviensia. Series Botanica et Zoologia. Supplement
|
1997
|
tom 39
|
nr 1
9
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Content available

Epibenthic diversity and productivity on a heavily trawled Barents Sea bank (Tromsoflaket)

51%
Kedra M., Renaud P. E., Andrade H.
Oceanologia
|
2017
|
tom 59
|
nr 2
Shallow Arctic banks have been observed to harbour rich communities of epifaunal organisms, but have not been well-studied with respect to composition or function due to sampling challenges. In order to determine how these banks function in the Barents Sea ecosystem, we used a combination of video and trawl/dredge sampling at several locations on a heavily trawled bank, Tromsøflaket — located at the southwestern entrance to the Barents Sea. We describe components of the benthic community, and calculate secondary production of dominant epifaunal organisms. Forty-six epibenthic taxa were identified, and sponges were a significant part of the surveyed benthic communities. There were differences in diversity and production among areas, mainly related to the intensity of trawling activities. Gamma was the most diverse and productive area, with highest species abundance and biomass. Trawled areas had considerably lower species numbers, and significant differences in epifaunal abundance and biomass were found between all trawled and untrawled areas. Trawling seems to have an impact on the sponge communities: mean individual poriferan biomass was higher in untrawled areas, and, although poriferans were observed in areas subjected to more intensive trawling, they were at least five times less frequent than in untrawled areas.
10
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Okiem ryby - nowe spojrzenie na rozwój sieci neuronalnych i choroby neurorozwojowe

51%
Kedra M., Jaworski J., Zmorzynska J.
Wszechświat
|
2016
|
tom 117
|
nr 10-12
11

Eight species that rule today’s European Arctic fjord benthos

45%
Weslawski J. M., Wlodarska-Kowalczuk M., Kedra M., Legezynska J., Kotwicki L.
Polish Polar Research
|
2012
|
tom 33
|
nr 3
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The malacostracan fauna of two Arctic fjords (West Spitsbergen): the diversity and distribution patterns of its pelagic and benthic components

39%
Legezynska J., Wlodarska-Kowalczuk M., Gluchowska M., Ormanczyk M., Kedra M., Weslawski J. M.
Oceanologia
|
2017
|
tom 59
|
nr 4
This study examines the performance of pelagic and benthic Malacostraca in two glacial fjords of west Spitsbergen: Kongsfjorden, strongly influenced by warm Atlantic waters, and Hornsund which, because of the strong impact of the cold Sørkapp Current, has more of an Arctic character. The material was collected during 12 summer expeditions organized from 1997 to 2013. In all, 24 pelagic and 116 benthic taxa were recorded, most of them widely distributed Arctic-boreal species. The advection of different water masses from the shelf had a direct impact on the structure of the pelagic Malacostraca communities, resulting in the clear dominance of the sub-arctic hyperiid amphipod Themisto abyssorum in Kongsfjorden and the great abundance of Decapoda larvae in Hornsund. The taxonomic, functional and size compositions of the benthic malacostracan assemblages varied between the two fjords, and also between the glacier-proximate inner bays and the main fjord basins, as a result of the varying dominance patterns of the same assemblage of species. There was a significant drop in species richness in the strongly disturbed glacial bays of both fjords, but only in Hornsund was this accompanied by a significant decrease in density and diversity, probably due to greater isolation and poorer quality of sediment organic matter in its innermost basin. Our results suggest that the diversity and distribution of benthic malacostracans in these two fjords are only distantly related to the different hydrological regimes; rather, they are governed by locally acting factors, such as depth, sediment type, the variety of microhabitats and the availability and quality of food.
13
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Urban vs. rural patients. Differences in stage and overall survival among patients treated surgically for lung cancer

39%
Rybojad P., Dluski D., Rybojad B., Kedra M., Sawicki M., Skoczylas P., Tabarkiewicz J.
Annals of Agricultural and Environmental Medicine
|
2013
|
tom 20
|
nr 1
Introduction. Besides the undoubted influence of risk factors on morbidity and survival time, there are also other environmental factors, such as awareness of the prevalence of risk factors and the availability of modern diagnosis and treatment methods. Objective. To evaluate differences in lung cancer 5-year overall survival rates between urban and rural patients hospitalized in the Department of Thoracic Surgery of the Medical University in Lublin, Poland, and possible influence of several risk factors on these rates. Materials and methods. The analysis was based on 125 lung cancer patients who underwent surgical procedures in years 2006-2007 and who agreed to take part in the survey. The study aimed at recognition of the health situation and selected demographic traits of people who had been treated surgically for lung cancer. The differences were evaluated between rural and urban inhabitants in gender, age, lung function, smoking habits, exposure to risk factors at work, family history of cancer, staging of the disease, histological type of cancer, post-surgical treatment, and their possible influence on overall survival. Results. The results showed that the only noted differences between urban and rural population were in tobacco smoking and lung function. Survival rates were very similar and did not differ from the European average. Conclusions. The assumption that Polish rural patients are presenting with later cancer stages at the time of diagnosis, and have worse chances for survival, has become invalid in modern times.
14

Hidden diversity in Arctic crustaceans. How many roles can a species play?

39%
Weslawski J. M., Opanowski A., Legezynska J., Maciejewska B., Wlodarczak-Kowalczuk M., Kedra M.
Polish Polar Research
|
2010
|
tom 31
|
nr 3
15
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A huge biocatalytic filter in the centre of Barents Sea shelf?

33%
Weslawski J. M., Kedra M., Przytarska J., Kotwicki L., Ellingsen I., Skardhamar J., Renaud P., Goszczko I.
Oceanologia
|
2012
|
tom 54
|
nr 2
A primary production model for the Barents Sea shows a hot spot of organic carbon settlement to the sea bed over 100 km long, a shallow pile of highly permeable sediments (mainly large Balanus, Mya and Pecten shell fragments over 1 cm in size) of glacial origin. Hydrodynamic flow models suggest an intensive, deep flow of near-bottom waters into the sediment. Depending on wave height, water in shallow (30 m depth) places may percolate more than 5 m into the sediment. During 10 days of stormy weather as much as 4 to 8 kg wet weight pelagic biomass can be processed per square metre through this extremely permeable sediment. Analogous processes known in coastal waters lead to intense biocatalytic phenomena and metabolism of organic carbon within the seabed, estimated here as more intense than surface consumption. Spitsbergenbanken may be acting as a huge sink for organic carbon and an important source of nutrients in one of the most productive areas of the North Atlantic.
16

Soft bottom macrofauna of an All Taxa Biodiversity Site: Hornsund (77○N, Svalbard)

33%
Kedra M., Gromisz S., Jaskula R., Legezynska J., Maciejewska B., Malec E., Opanowski A., Ostrowska K., Wlodarska-Kowalczuk M., Weslawski J. M.
Polish Polar Research
|
2010
|
tom 31
|
nr 4
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