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1

Causes of L-cysteine neurotoxicity

100%
Wlodek L.
Acta Biologica Cracoviensia. Series Zoologia
|
2002
|
tom 44
2

The reaction of sulfhydryl groups with carbonyl compounds

88%
Wlodek L.
Acta Biochimica Polonica
|
1988
|
tom 35
|
nr 4
3

3-Mercaptopyruvate sulphurtransferase fromrat erythrocytes

63%
Wlodek L., Ostrowski W.-S.
Acta Biochimica Polonica
|
1982
|
tom 29
|
nr 1-2
4

Formation of 2-methyl-2,4-thiazolidinedicarboxylic acid from L-cysteine in rat tissues

63%
Wlodek L., Czubak J.
Acta Biochimica Polonica
|
1984
|
tom 31
|
nr 3
5

S-tiolacja bialek jako mechanizm antyoksydacyjny i regulacyjny.

63%
Wlodek L., Iciek M.
Postępy Biochemii
|
2003
|
tom 49
|
nr 2
77-84
6

Biologiczne wlasciwosci kwasu liponowego

63%
Bilska A., Wlodek L.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
tom 56
|
nr 2
201-219
7

Dlaczego pojawia sie tolerancja na nitrogliceryne?

63%
Wlodek L., Sokolowska M.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
|
tom 55
|
nr 5
673-685
8

2-methyl-thiazolidine-2,4-dicarboxylic acid protects against paracetamol induced toxicity in human liver derived HepG2 cells

63%
Wlodek L., Rommelspacher H.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 4
The effects of 2-methyl-thiazolidine-2,4-dicarboxylic acid (CP) on paracetamol-induced toxicity were investigated and evaluated in a human liver derived HepG2 cell line. Incubation of the cells with CP (2 mM and 10 mM) drastically attenuated the GSH and cysteine depletion caused by toxic concentrations of paracetamol (1 mM and 5 mM). When CP (10 mM) was introduced alone into the medium, the level of malondialdehyde and the reactive oxygen species were maintained at the control levels with a simultaneous increase of non-protein sulfhydryl in the cells. Thus, the results of our work prove that CP is a non-toxic precursor of cysteine and GSH, and successfully prevents paracetamol toxicity in HepG2 cells.
9

Bioactivation of nitroglycerin to nitric oxide (NO) and S-nitrosothiols in rat liver and evaluation of the coexisting hypotensive effect

51%
Sokolowska M., Bednarski M., Filipek B., Wlodek L.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
10

The selective effect of cystathionine on doxorubicin hepatotoxicity in tumor-bearing mice

51%
Kwiecien I., Michalska M., Wlodek L.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
11

Transferazy glutationowe - bioaktywacja S-koniugatow glutationu z udzialem beta-liazy

51%
Sokolowska-Jezewicz M., Kryczyk A., Dudzik P., Wlodek L.
Postępy Biochemii
|
2007
|
tom 53
|
nr 4
374-388
12

The gamma-glutamyl transferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups

51%
Wlodek P., Sokolowska M., Smolenski O., Wlodek L.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 2
The present work was aimed to obtain information about age-dependent changes of γ-glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl com­pounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated. The results indicate that the activity of GGT and NPSH levels in the kidneys are re­duced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the oldest animals. These findings indicate that the capacity for extracellular glutathione degradation and, in consequence, the availability of cysteine for intracellular glutathione biosynthesis may be impaired. The increased PB-Cys level indicates potentiation of the thiolation reaction, i.e. development of pro­tein-mixed disulfides. These results reveal age dependent disturbances in the thiol-disulfide equilibrium in the kidneys which leads to an imbalance between pro- and antioxidatory processes.
13

The effect of nitrogen oxide level modulation on thiol compound content and anaerobic sulfur metabolism in mouse kidney and liver

51%
Sokolowska M., Wlodek L., Wrobel M., Srebro Z.
Acta Biologica Cracoviensia. Series Zoologia
|
1999
|
tom 41
14

Allyl disulfide of garlic influence on number of glial cells containing Gomori-positive cytoplasmic granulation as well as sulfane sulfur level and sulfurtransferases activity in the mouse tissues

45%
Wlodek L., Iciek M., Bilska A., Ksiazek L., Srebro Z.
Herba Polonica
|
2003
|
tom 49
|
nr 3-4
15

Antioxidative properties of A-lipoic acid examined in the striatum and prefronta cortex of the reserpine-treated rats

45%
Bilska A., Dubiel M., Sokolowska-Jezewicz M., Lorenc-Koci E., Wlodek L.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
16

Influence of allyl disulfide and cyanide on sulfane sulfur level, activity of sufurtransferases and number of granules rich in sulfur in the mouse brain

45%
Wlodek L., Iciek M., Bilska A., Ksiazek L., Srebro Z.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
17

The effect of modilation of gamma-glutamyltranspeptidase activity on S-thiolation process, cell proliferation and caspase-3 activity in HepG2 cells

45%
Iciek M., Chwatko G., Rokita H., Bald E., Wlodek L.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
18

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

45%
Iciek M., Chwatko G., Lorenc-Koci E., Bald E., Wlodek L.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 3
The redox status of plasma thiols can be a diagnostic indicator of different patho­logical states. The aim of this study was to identify the age dependent changes in the plasma levels of total, free and protein bound glutathione, cysteine and homocysteine. The determination was conducted in plasma of three groups of rats: 1) young (3-month-old), 2) middle aged (19-month-old), and 3) old (31-month-old). To­tal levels of glutathione, cysteine and homocysteine and their respective free and protein-bound fractions decreased with age. The only exception was a rise in free homocysteine concentration in the middle group, which indicates a different pattern of transformations of this thiol in plasma. The drop in the level of protein-bound thiols suggests that the antioxidant capacity of plasma diminishes with age, which, consequently, leads to impaired protection of -SH groups through irreversible oxida­tion. The plasma sulfane sulfur level also declines with age, which means that aging is accompanied by inhibition of anaerobic sulfur metabolism.
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