Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 15

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Molekularne aspekty infekcji wywolanej Helicobacter pylori

100%
Arabski M., Blasiak J.
Postępy Biologii Komórki
|
2003
|
tom 30
|
nr 4
679-694
2

The diffusion of antibiotics throught an artificial membrane in the presence of Proteus vulgaris O25 lipopolysaccharides

81%
Arabski M., Wasik S., Dworecki K., Kaca W.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
3

Involvement of free radicals in the genotoxity of amoxicillin in human gastric mucosa cells and lymphocytes

71%
Arabski M., Wisniewska-Jarosinska M., Kazmierczak P., Drzewowski J., Blasiak J.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
4

Analysis of ciprofloxacin and gentamicin diffusion in Proteus mirabilis O18 biofilm by laser interferometry method

71%
Arabski M., Wasik S., Zych M., Lakomiec W., Kaca W.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 4
Laser interferometry is a measurement technique used in physical sciences, with a potential for new applications in microbiology. Our previously studies, focused on the quantitative analysis of antibiotics diffusion through membranes or their releasing from gel structure, indicate that this method might be useful in analysis of substances diffusion across the bacterial biofilms. As antibiotic - biofilm interaction model, we tested above method for determination of ciprofloxacin or gentamicin diffusion through Proteus mirabilis O18 biofilm. Laser interferometry analysis of antibiotics diffusion showed that the amount of ciprofloxacin transported through mature biofilm is 1.9 times higher than gentamicin. It was correlated with lower level of gentamicin in compare to the level of ciprofloxacin in biofilm, which amounts were predicted in biofilm during diffusion process by laser interferometry method. We suggest that the analysis of antibiotic diffusion in biofilm might by helpful in evaluation of effectiveness of antibacterial agents.
5

Testing sorption properties of halloysite by means of the laser interferometry method

71%
Wasik S., Arabski M., Maciejec K., Suchanek G., Swiercz A.
Current Topics in Biophysics
|
2014
|
tom 37
|
nr 1
6

Application of membrane system for investigating sorption properties of halloysite

71%
Wasik S., Arabski M., Suchanek G., Swiercz A., Drabik M.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
7

DNA damage in human colonic mucosa cells induced by bleomycin and the protective action of vitamin E

71%
Wozniak K., Arabski M., Malecka-Panas E., Drzewoski J., Blasiak J.
Cellular and Molecular Biology Letters
|
2004
|
tom 09
|
nr 1
Using the alkaline comet assay, we showed that bleomycin at 0.1-5 μg/ml induced DNA strand breaks and/or alkali-labile sites, measurable as the comet tail moment, in human colonic mucosa cells. This DNA damage was completely repaired during a 120-minute post-treatment incubation of the cells. Post-treatment of the bleomycin-damaged DNA with 3-methyladenine-DNA glycosylase II (AlkA), an enzyme recognizing alkylated bases, gave rise to a significant increase in the extent of DNA damage, indicating that the drug could induce alkylative bases in DNA. We did not observe any change in the comet tail moment in the presence of catalase. Vitamin E ((+)-α-tocopherol) decreased DNA damage induced by bleomycin. The results obtained suggest that hydrogen peroxide might not be involved in the formation of DNA lesions induced by bleomycin in the colonic mucosa cells, and that vitamin E may exert protective effects on these cells.
8

Potential use of halloysite in phytoremediation of soils contaminated with heavy metals

61%
Swiercz A., Suchanek G., Slomkiewicz P., Majewska U., Wasik S., Arabski M., Drabik M.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
9

Comparison of transport polymer membrane modified with one- and two-sided method of ion implantation

61%
Drabik M., Zuk J., Arabski M., Dworecki K., Suchanek G., Swiercz A., Wasik S.
Current Topics in Biophysics. Supplement
|
2013
|
tom 36
|
nr 2A: Posters
10

Cytotoxic and antimicrobial properties of cobalt complexes with imidazole derivatives

61%
Galczynska K., Kurdziel K., Madej L., Wegierek-Ciuk A., Lankoff A., Arabski M.
Postępy Mikrobiologii. Suplement
|
2017
|
tom 56
|
nr 1
11

The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis

51%
Gałczynska K., Kurdziel K., Adamus-Bialek W., Wasik S., Szary K., Drabik M., Wegierek-Ciuk A., Lankoff A., Arabski M.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 4
12

Human complement activation by smooth and rough Proteus mirabilis lipopolysaccharides

51%
Kaca W., Arabski M., Fudala R., Holmstrom E., Sjoholm A., Weintraub A., Futoma-Koloch B., Bugla-Ploskonska G., Doroszkiewicz W.
Archivum Immunologiae et Therapiae Experimentalis
|
2009
|
tom 57
|
nr 5
383-391
13

Detection of UPEC in human bladder cancer cells

51%
Madej L., Galczynska K., Adamus-Bialek W., Filipiak A., Gwizda E., Kowalska E., Tulej D., Lipinski M., Rozanski W., Arabski M.
Postępy Mikrobiologii. Suplement
|
2017
|
tom 56
|
nr 1
14

Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG

51%
Arabski M., Kazmierczak P., Wisniewska-Jarosinska M., Morawiec Z., Morawiec-Bajda A., Klupinska G., Drzewoski J., Chojnacki J., Blasiak J.
Cellular and Molecular Biology Letters
|
2006
|
tom 11
|
nr 4
The pathogenesis of stomach cells can be associated with their susceptibility to exogenous dietary irritants, like nitrosamines such as dimethylnitrosamines (DMNA), and to the effects of non-dietary factors, including Helicobacter pylori infection. We used N-methyl-N'-nitro N-nitrosoguanidyne (MNNG) as a surrogate agent that induces a spectrum of DNA damage similar to DMNA. Using the alkaline comet assay, we showed that antioxidants--vitamins C and E, quercetin, and melatonin--reduced the genotoxic effect of MNNG in H. pylori-infected and non-infected human gastric mucosa cells (GMCs). To compare the sensitivity of the stomach and the blood, the experiment was also carried out in peripheral blood. We observed a higher level of DNA damage induced by MNNG in H. pylori-infected than in noninfected GMCs. We did not note any difference in the efficacy of the repair of the damage in either type of GMC. H. pylori infection may play an important role in the pathogenesis of GMCs, as it can modulate their susceptibility to dietary mutagens/carcinogens, thus contributing to gastric cancer.
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis

42%
Wegierek-Ciuk A., Arabski M., Kedzierawski P., Florek A., Solowiej D., Gozdz S., Lisowska H., Kowalik A., Kowalska M., Wojcik A., Polanska J., Lankoff A.
Journal of Pre-Clinical and Clinical Research
|
2015
|
tom 09
|
nr 2
Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.