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Porównawcze wyniki wielokrotnych badań białka całkowitego oraz frakcji białek surowicy krwi i cholesterolu w związku z żywieniem wybranej grupy ludzi zdrowych

100%

Kubica J., Rdzanek J., Szczerbinski B., Kuzma M.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1965

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tom 53

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Wplyw zwiazkow fenolowych na transferazy glutationowe z mozgu ssakow

100%

Sawicki J., Kuzma M., Baranczyk-Kuzma A.

Bromatologia i Chemia Toksykologiczna

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2001

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tom 34

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nr 2

149-154

W pracy badano wpływ fenolu i jego pochodnych (siarczan fenolu, 1-naftol, siarczan 1-naftolu, p-nitrofenol, siarczan p-nitrofenolu, p-nitroanizol, p-aminofenol, fenacetyna, paracetamol) na aktywność obojętnej izoformy transferazy glutationowej (GST) [EC 2.5.1.18] wyizolowanej z kory mózgu wołu i świni. Stwierdzono, że pochodne fenolu silniej hamują aktywność badanego enzymu niż sam fenol. Wrażliwość GST na działanie tych związków w mniejszym stopniu zależy od mózgowej lokalizacji enzymu niż od ich budowy chemicznej.

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Effect of biogenic amines and their derivatives on glutathione conjugation in brain

100%

Sawicki J., Kuzma M., Maslinski S., Baranczyk-Kuzma A.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

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nr 2

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Ekspresja transferazy S-glutationowej pi w osrodkowym ukladzie nerwowym myszy podczas starzenia

88%

Kazmierczak B., Usarek E., Gajewska B., Kuzma M., Baranczyk-Kuzma A.

Medycyna Weterynaryjna

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2005

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tom 61

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nr 05

577-579

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Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain

88%

Baranczyk-Kuzma A., Kuzma M., Gutowicz M., Kazmierczak B., Sawicki J.

Acta Biochimica Polonica

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2004

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tom 51

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nr 1

GST pi, the main glutathione S-transferase isoform present in the human brain, was isolated from various regions of the brain and the in vitro effect of tricyclic antidepressants on its activity was studied. The results indicated that amitripyline and doxepin — derivatives of dibenzcycloheptadiene, as well as imipramine and clomipramine — derivatives of dibenzazepine, inhibit the activity of GST pi from frontal and parietal cortex, hippocampus and brain stem. All these tricyclics are non- competitive inhibitors of the enzyme with respect to reduced glutathione and non- competitive (amitripyline, doxepin) or uncompetitive (imipramine, clomipramine) with respect to the electrophilic substrate. Their inhibitory effect is reversible and it depends on the chemical structure of the tricyclic antidepressants rather than on the brain localization of the enzyme. We conclude that the interaction between GST pi and the drugs may reduce their availability in the brain and thus affect their therapeutic activity. On the other hand, tricyclic antidepressants may decrease the efficiency of the enzymatic barrier formed by GST and increase the exposure of brain to toxic electrophiles. Reactive electrophiles not inactivated by GST may contribute in adverse effects caused by these drugs.

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Zmiany w ekspresji izoform bialka tau w mozgu myszy w zaleznosci od wieku

76%

Usarek E., Kuzma M., Kazmierczak B., Muench C., Ludolph A. C., Baranczyk-Kuzma A.

Medycyna Weterynaryjna

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2006

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tom 62

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nr 02

231-233

au is a microtubule-associated protein important for the assembly and stabilization of microtubules. Six tau isoforms are produced in the central nervous system from one single gene as a result of the alternative splicing of exons 2, 3 (N-terminal part) and exon 10 (C-terminal part). The shortest isoform (2-3-10-, 0N 3R) is characteristic for fetal brains, whereas the remaining (2+3-10-, 1N 3R; 2+3+10-, 2N 3R; 2-3-10+, 0N 4R; 2+3-10+, 1N 4R; 2+3+10+, 2N 4R) for adult brains. The aim of the study was to establish a profile of tau protein variants in the C57BL/6J mouse frontal cortex during the aging process. The total RNA was isolated from tissues, followed by reverse transcription and PCR reaction. It was found that the sequence encoded by exon 10 was absent in the youngest 5-day old newborns (isoform 3R), while it was present in 21, 70 and 140-day old animals (isoform 4R). The most abundant isoform in 5-day old mice was 1N and accounted for 66% of the total tau protein. The percentage of 1N isoforms lowered with age and was 31% in 140-day old animals. The total percentage of 0N isoforms was 11% in 5-day old mice and was approximately threefold lower than in each of the older groups. It may be concluded that alternative splicing of the tau protein undergoes age-dependent regulation in the mouse brain cortex.

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Does preconditioning protect against experimental ischaemia-reperfusion injury via cholinergic stimulation?

64%

Dzierzkowska J., Gajewska J., Witanowska A., Deptuch T. W., Kurenko M., Gajewski M., Mautiris J., Kuzma M., Dron T., Maslinski S.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

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nr 2

8

Preclinical characteristics and regenerative potential of adipose – derived MSC

52%

Sarnowska A., Figiel-Dabrowska A., Szczepanik E., Kuzma M., Mierzewska H., Antczak-Marach D., Kruk M., Terczynska I., Krzesniak N., Sawicka E., Nowak A., Noszczyk B., Kaminska A., Marchel A., Domanska-Janik K.

Acta Neurobiologiae Experimentalis

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2017

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tom 77

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nr Suppl.1

While the rapid development of stem cell-based therapies are nowadays running, the reliable protocols leading to safe and effective way for cell isolation, expansion and commitment in vitro according to distinguished therapeutic purposes still need more consensus and standardization. In order to obtain particular disease-committed therapeutic cells we have screened various culture conditions, especially new systems involving lowered oxygen tension and small molecule treatments which may “rejuvenates” MSC. We also looked on the changes in grow dynamics of long-term cultures in various oxygen concentrations to dissect changes that predict genetic instability of cultivated cells. The standardization of such type of culture (by additional criteria beyond the framework developed by ISCT) should further enhance life-span, expansion and differentiation potential of MSCs needed for more effective regeneration of diseased brain. In recent years we have also entered into the clinic with individual medical experiments (in accordance with the guidelines described by A. Korczyn’ Sieratzki – Chair of Neurology Tel Aviv University 2010) based on mesenchymal regenerative cell therapy to elaborate save therapeutic procedures for autoimmune epilepsy, ALS and vast nerve injury. First results are promising and indicate regenerative and immunomodulatory properties of transplanted MSC. FINANCIAL SUPPORT: The work was supported by National Centre for Research and Development grant No STRATEGMED 1/234261/2/NCBR/2014.

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Biomin - 10 lat sukcesów na rynku w Polsce!

50%

Kuzma M.

Weterynaria w Terenie

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2019

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tom 13

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nr 2

Ograniczanie wyników

Porównawcze wyniki wielokrotnych badań białka całkowitego oraz frakcji białek surowicy krwi i cholesterolu w związku z żywieniem wybranej grupy ludzi zdrowych

Wplyw zwiazkow fenolowych na transferazy glutationowe z mozgu ssakow

Effect of biogenic amines and their derivatives on glutathione conjugation in brain

Ekspresja transferazy S-glutationowej pi w osrodkowym ukladzie nerwowym myszy podczas starzenia

Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain

Zmiany w ekspresji izoform bialka tau w mozgu myszy w zaleznosci od wieku

Does preconditioning protect against experimental ischaemia-reperfusion injury via cholinergic stimulation?

Preclinical characteristics and regenerative potential of adipose – derived MSC

Biomin - 10 lat sukcesów na rynku w Polsce!