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1
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Potato dietary fibre - preliminary characterization of the properties and nutritional effects - a review

100%
Pastuszewska B., Antushevich H., Tusnio A., Taciak M.
Polish Journal of Food and Nutrition Sciences
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2009
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tom 59
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nr 3
A potential source of potato dietary fibre (PDF) is potato pulp, a waste product of the starch industry. The refined potato pulp (PDF preparation) contains 50-60% of DF, 10-20% of starch and 6% of protein (on dry matter basis). PDF consists of about 55% of insoluble (mainly cellulose) and 45% of soluble (mainly pectins) fraction; has low viscosity and relatively high water-holding capacity but lower fecal bulking properties than cellulose. It is intensively fermented in the large intestine, yielding a high amount of acetate and butyrate. Feeding PDF does not affect greatly morphology and morphometry of the intestinal tract. It delays the rate of passage of digesta (as compared with cellulose), reduces fat and protein digestibility in the whole digestive tract and does not affect ileal protein digestibility (as compared with cellulose and pectin). It seems to improve mineral absorption. Few experimental results do not allow to conclude whether PDF decreases blood concentration of triglycerides, total cholesterol or LDL fraction. Data on the effects of PDF on glucose and insulin levels are also scarce and insufficient.
2

Effect of apelin on mitosis, apoptosis and DNA repair enzyme OGG 1/2 expression in intestinal cell lines IEC-6 and Caco-2

88%
Antushevich H., Krawczynska B., Kapica M., Herman A. P., Zabielski R.
Folia Histochemica et Cytobiologica
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2014
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tom 52
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nr 1
3
Content available remote

The effect of exogenous apelin on the secretion of pancreatic juice in anaesthetized rats

76%
Kapica M., Jankowska A., Antushevich H., Pietrzak P., Bierla J. B., Dembinski A., Zabielski R.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 1
4

Photoperiodic conditions as a factor modulating leptin influence on pro-inflammatory cytokines and their receptors gene expression in ewe’s aorta

76%
Krawczynska A., Antushevich H., Bochenek J., Wojtulewicz K., Pawlina B., Herman A. P., Zieba D. A.
Journal of Animal and Feed Sciences
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2019
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tom 28
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nr 2
Atherosclerosis, a chronic inflammation state of the aorta, is characterised by increased levels of pro-inflammatory cytokines (tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-6). Sheep is used in both cardiovascular and immunological studies; besides, ‘long-day’ ewe can be a model of leptin resistance state. The aim of the study was to examine whether photoperiodic conditions (long-day (LD) and short-day (SD) seasons) are a key factor modulating exogenous leptin influence on pro-inflammatory cytokines and their receptors gene expression in aorta of ewe’s with or without prior induction of acute inflammation. The experiment was conducted on 48 ewes during SD and LD seasons which were randomly divided into 4 groups: control; with LPS injection (400 ng/kg of body weight (BW)); with leptin injection (20 μg/kg BW); and with LPS and 30-min later leptin injection. Three hours after LPS/control treatment animals were euthanized to collect the thoracic aorta samples. In both seasons leptin injection intensified LPS-induced increase in IL1B gene expression but only in SD season leptin injection increased IL1R1 and IL1R2 gene expressions. The leptin injection increased IL6 gene expression but only in SD season. In the LD season leptin enhanced the LPS effect on IL6 gene expression. Neither TNFA nor its receptors gene expression was influenced by leptin regardless of season. In the thoracic aorta tissue an exogenous leptin exerts effect on pro-inflammatory cytokines and their receptors gene expression; however in ewe this influence depends on photoperiodic conditions. Moreover, leptin can moderate progression of the inflammation reaction in this tissue.
5
Content available remote

The role of apelin in the modulation of gastric and pancreatic enzymes activity in adult rats

76%
Antushevich H., Kapica M., Krawczynska A., Herman A., Kato I., Kuwahara A., Zabielski R.
Journal of Physiology and Pharmacology
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2016
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tom 67
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nr 3
6

Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

76%
Kapica M., Puzio I., Kato I., Kuwahara A., Zabielski R., Antushevich H.
Journal of Animal and Feed Sciences
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2018
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tom 27
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nr 2
It is suggested that obestatin can stimulate the secretion of pancreatic juice in rats and this effect is abolished by vagotomy. Thus, the aim of the present study was to further elucidate the mechanism by which obestatin controls the exocrine pancreas secretion. Anesthetized male Wistar rats (200 ± 15 g body weight) were administered intravenously (iv) and intraduodenaly (id) every 30 min obestatin in boluses of 30, 100 and 300 nmol ∙ kg−1 body weight and 15 min later pancreatic-biliary juice (PBJ) was collected to determine the PBJ volume, total protein and enzymes activity. Obestatin injections were also done following subdiaphragmatic vagotomy, capsaicin deafferentation and pharmacological blockage of the mucosal cholecystokinin 1 (CCK1) receptor with tarazepide. Dispersed acinar cells were isolated from rat pancreas by collagenase digestion, stimulated with CCK-8 (10−10 M) and incubated with obestatin (10−9–10−6 M) in vitro. It was noted that iv and id obestatin administrations did not affect the PBJ volume but increased protein and trypsin outputs regardless way of administration, and amylase and lipase outputs after id injection. Similarly to vagotomy, the capsaicin and tarazepide pre-treatments abolished the effects of obestatin. In contrast to the in vivo experiment, the treatment of dispersed pancreatic cells with the CCK-8+obestatin combination showed that obestatin decreased the CCK-8-stimulated amylase release from acinar cells in vitro, but obestatin alone did not exert effect on amylase release. So, it is thought that obestatin can stimulate the exocrine pancreas secretion via an indirect vagal mechanism, whilst its direct action on the acinar cells is also possible but with the opposite effects
7
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Influence of fundectomy and intraperitoneal or intragastric administration of apelin on apoptosis, mitosis, and DNA repair enzyme OGG1,2 expression in adult rats gastrointestinal tract and pancreas

64%
Antushevich H., Pawlina B., Kapica M., Krawczynska A., Herman A. P., Kuwahara A., Kato I., Zabielski R.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 4
8

The apelin-13 influences the activity of pancreatic enzymes in young rats

64%
Antushevich H., Kapica M., Kuwahara A., Kato I., Krawczynska A., Herman A. P., Pawlina P., Zabielski R.
Journal of Animal and Feed Sciences
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2016
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tom 25
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nr 2
Apelin and its APJ receptor are present inter alia in colostrum and in the young animal gastrointestinal tract. This peptide exerts numerous effects participating in the appetite and drinking behaviour, gastric acid and insulin secretion. The aim of the study was to investigate the effect of apelin-13 on the activity of pancreatic and gastric enzymes in young animals. The two experiments were carried out on weaning Wistar rats (50 ± 10 g) which received the apelin-13 or physiological saline (in the corresponding control groups) by intragastric or intraperitoneal way twice a day for 10 days (100 nmol · kg–1 body weight). At the end of each experiment rats were sacrificed and blood samples were collected for apelin and cholecystokinin (CCK) radioimmunoassay. The fragments of the pancreas and stomach were weighted and frozen for the further digestive enzymes activity analysis. The intragastric and intraperitoneal administration of apelin-13 increased plasma CCK level in young rats. The intraperitoneal injection of apelin-13 stimulated pancreatic trypsin, -amylase and lipase activity, but had no effect on the activity of gastric enzymes. On the other hand, the intragastric administration of apelin-13 stimulated only the activity of pancreatic lipase and had no effect on the activity of gastric pepsin and rennet. So, circulating apelin exerts the most pronounced effect on pancreatic enzymes activity in young rats, but neither circulating nor luminal apelin influences gastric enzymes activity. Regardless the route of administration, apelin stimulates lipase activity which points out its considerable role in the regulation of the fat digestion.
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