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1

Automatyczne systemy pakowania ladunkow paletowych

100%
Macko M.
Opakowanie
|
2006
|
tom 51
|
nr 01
26-28
Elastyczność metod formowania ładunków paletowych sprawia, że znajdują one zastosowanie w każdej niemal branży przemysłowej. Kryteria doboru rodzaju opakowań są ściśle związane z rodzajem produktów, sposobem ich przechowywania i dystrybucji, a czasem także z wymaganiami odbiorców. Maszyny do pakowania ładunków paletowych są bardzo różne. Mogą to być np. zarówno proste owijarki, jak też wysokowydajne automaty.
2

Aspects of multi-edge milling of wood elements

63%
Warmbier K., Macko M.
Annals of Warsaw Agricultural University. Forestry and Wood Technology
|
2006
|
tom 59
3

Computer design of milling system for wood materials

63%
Warmbier K., Macko M.
Annals of Warsaw Agricultural University. Forestry and Wood Technology
|
2004
|
tom 55
A variety of material - properties, shape of parts and product quality after milling justify a search for constructional solutions for the energy-saving design of mill. State of the art technology makes it possible to continue computer aided research of milling as well as to simulate machine mechanisms investigation. The paper indicates possibilities of CAD application aiming to recognize constructional features of mill especially intended for wood-elements. An overview of computer transformation of mill design is in this paper presented, describing the development of modelling & simulation in a variety of contexts of research such as preparing schedule, as well as analysis of obtained results.
4

The influence of design features of shredder for wood material

63%
Warmbier K., Macko M.
Annals of Warsaw Agricultural University. Forestry and Wood Technology
|
2005
|
tom 57
The possibilities of using CAD tools in aim to improve design of milling system for wood materials have already presented. In this paper we are focusing on the possibilities of using the results obtained from computer simulation - especially strength and kinematic condition, but what is more effective we try to check how the results can be compared with the results obtained during milling of wood materials in laboratory condition. The initial analysis indicated new areas of construction which can be changed in aim to decrease energy needed to milling and increase the quality of final product.
5
Content available remote

Exposition of newborn rats to bacterial endotoxin impairs pancreatic enzyme secretion at adult age

33%
Jaworek J., Nawrot-Porabka K., Leja-Szpak A., Szklarczyk J., Macko M., Bonior J., Stachura J., Konturek S. J., Pawlik W. W.
Journal of Physiology and Pharmacology
|
2007
|
tom 58
|
nr 2
Lipopolysaccharide (LPS, endotoxin) is the component of the cellular wall of Gram negative bacteria. Endotoxemia (sepsis) could produce multiorgan failure and in the early period of life LPS are responsible for the changes of metabolism and for the reduction of protein synthesis. The influence of neonatal endotoxemia on the pancreas at adults has not been investigated yet. The aim of this study was to assess the pancreatic exocrine function in the adult rats which have been subjected, in the neonatal period of life, to chronic LPS pretreatment. LPS from E. coli or S. typhi at doses of 5, 10 or 15 mg/kg-day was administered intraperitoneally (i.p.) to the suckling rats (30 g) during 5 consecutive days. Three months later these animals (300 g) were equipped with pancreato-biliary fistulae for the in vivo secretory study. Amylase release from isolated pancreatic acini obtained from these rats was also assessed. Pancreatic tissue samples were taken for histological assessment and for the determination of gene expression for CCK1 receptor by RT-PCR. Pancreatic amylase secretions stimulated by caerulein or by diversion of pancreatic-biliary juice to the exterior (DBPJ) was significantly, and dose-dependently reduced in the adult rats which have been subjected in infancy to chronic pretreatment with LPS from E. coli or S. typhi, as compared to the untreated control. In these animals basal secretion was unaffected. In the rats pretreated with LPS in the suckling period of life caerulein-induced amylase release from isolated pancreatic acini was significantly decreased, as compared to the untreated with LPS control. This was accompanied by dose-dependent reduction of mRNA signal for CCK1 receptor on pancreatic acini. Neonatal endotoxemia failed to affect significantly pancreatic morphology as well as plasma amylase level in the adult rats. We conclude that neonatal endotoxemia reduces gene expression for CCK1 receptor and could produce impairment of the exocrine pancreatic function at adult age.
6
Content available remote

Endotoxemia in newborn rats attenuates acute pancreatitis at adult age

26%
Jaworek J., Konturek S. J., Macko M., Kot M., Szklarczyk J., Leja-Szpak A., Nawrot-Porabka K., Stachura J., Tomaszewska R., Siwicki A., Pawlik W. W.
Journal of Physiology and Pharmacology
|
2007
|
tom 58
|
nr 1
Bacterial endotoxin (lipopolysaccharide, LPS), at high concentration is responsible for sepsis, and neonatal mortality, however low concentration of LPS protected the pancreas against acute damage. The aim of this study was to investigate the effect of exposition of suckling rats to LPS on the course of acute pancreatitis at adult age. Suckling rat (30-40g) received intraperitoneal (i.p.) injection of saline (control) or LPS from Escherichia coli or Salmonella typhi (5, 10 or 15 mg/kg-day ) during 5 consecutive days. Two months later these rats have been subjected to i.p. caerulein infusion (25 µg/kg) to produce caerulein-induced pancreatitis (CIP). The following parameters were tested: pancreatic weight and morphology, plasma amylase and lipase activities, interleukin 1ß (IL-1 ß), interleukin 6 (IL-6), and interleukin 10 (IL-10) plasma concentrations. Pancreatic concentration of superoxide dysmutase (SOD) and lipid peroxidation products; malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been also measured. Caerulein infusion produced CIP in all animals tested, that was confirmed by histological examination. In the rats, which have been subjected in the neonatal period of life to LPS at doses 10 or 15 mg/kg-day x 5 days, all manifestations of CIP have been reduced. In these animals acute inflammatory infiltration of pancreatic tissue and pancreatic cell vacuolization have been significantly diminished. Also pancreatic weight, plasma lipase and a-amylase activities, as well as plasma concentrations of IL-1ß and IL-6 have been markedly decreased, whereas plasma anti-inflammatory IL-10 concentration was significantly increased in these animals as compared to the control rats, subjected in the infancy to saline injection instead of LPS. Caerulein-induced fall in pancreatic SOD concentration was reversed and accompanied by significant reduction of MDA + 4 HNE in the pancreatic tissue. The effects of LPS derived from E.coli or S.typhi were similar. Pretreatment of suckling rats with LPS at dose of 10 mg/kg-day x 5 days resulted in the most prominent attenuation of acute pancreatitis at adult age, whereas LPS at dose of 5 mg/kg-day x 5 days given to the neonatal rats failed to affect significantly acute pancreatitis induced in these animals 2 months later. We conclude that: 1/ Prolonged expositon of suckling rats to bacterial endotoxin attenuated acute pancreatitis induced in these animals at adult age. 2/ This effect could be related to the increased concentration of antioxidative enzyme SOD in the pancreatic tissue and to the modulation of cytokines production in these animals.
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