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  1. 34 Folia Histochemica et Cytobiologica

  2. 12 Bulletin of the Veterinary Institute in Puławy

  3. 10 Postępy Biologii Komórki

  4. 7 Cellular and Molecular Biology Letters

  5. 7 Folia Morphologica

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  1. 87 Dziegiel P.

  2. 28 Zabel M.

  3. 22 Podhorska-Okolow M.

  4. 18 Nowak M.

  5. 14 Madej J. A.

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  1. 1 2020

  2. 1 2019

  3. 1 2018

  4. 2 2016

  5. 7 2015

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1

Mikrodysekcja laserowa - nowoczesna technika wykorzystywana w biologii molekularnej

100%
Wizinska P., Dziegiel P.
Postępy Biologii Komórki
|
2011
|
tom 38
|
nr 3
2

The role of periostin in neoplastic processes

100%
Ratajczak-Wielgomas K., Dziegiel P.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 2
3

Rola metalotionein w procesie angiogenezy

100%
Wierzowiecka B., Dziegiel P.
Postępy Biologii Komórki
|
2013
|
tom 40
|
nr 3
4

Ekspresja metalotioneiny i jej korelacja z antygenem Ki-67 w gruczolakorakach gruczolu sutkowego suk

81%
Nowak M., Madej J. A., Dziegiel P.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 04
427-431
The aim of the research was to show the immunocytochemical expression of MT and Ki-67 and the correlation between these markers in spontaneous epithelium mammary gland cancer in bitches. The samples used in the research were extracted during surgical procedures from 20 bitches of different breeds, ranging from 6 to 15 years of age who had been diagnosed with mammary gland tumors. The prepared samples were then photographed with a microscope, to be later analyzed by a workstation comprised of a computer hooked up to a Carl Zeiss microscope model: Axiophot. The workstation was able to register images and then digitally analyze them. The MultiScaneBase V 8.08 program working on a Microsoft Windows platform was used to gather readings. The average correlation value between the Ki-67 and MT expression confirmed by many tests indicated a high index value of Ki-67 antigen as the prognostic agent. The study concluded that the presence of metalotionein in adenocarcinamas of the mammary gland in bitches does not indicate its connection with an increased proliferation potential of the cancer cells as is in the case in womens mammary gland tumors.
5

Rola czynnika tkankowego w angiogenezie i progresji nowotworów

81%
Jablonska K., Witkiewicz W., Dziegiel P.
Postępy Biologii Komórki
|
2013
|
tom 40
|
nr 1
6

Rola ekspresji metalotionein w rakach przewodu pokarmowego

81%
Fic M., Pula B., Rogala K., Dziegiel P.
Postępy Biologii Komórki
|
2013
|
tom 40
|
nr 1
7

Immunocytochemiczna lokalizacja HER2 i COX2 w komorkach nowotworow nablonkowych gruczolu sutkowego suk

81%
Nowak M., Dziegiel P., Dzimira S., Madej J. A.
Medycyna Weterynaryjna
|
2005
|
tom 61
|
nr 11
1284-1287
8

Porownanie ekspresji receptorow estrogenowych i progesteronowych w gruczolakorakach gruczolu sutkowego u suk z aktywnoscia mitotyczna komorek nowotworowych

81%
Nowak M., Madej J. A., Dziegiel P.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 10
1211-1215
The study aimed at monitoring the expression of oestrogen (ER) and progesterone (PGR) receptors in mammary gland adenocarcinomas in bitches as compared to the mitotic activity of the neoplastic cells. Material for the study involved samples of mammary tumors obtained during surgery from 48 bitches of various races, aged 7 to 15 years. The obtained preparations were microphotographed and the patterns were subjected to computer-assisted image analysis in a system consisting of a computer linked to an Axiophot light microscope (Carl Zeiss). The expression of ER, PgR and of Ki-67 was evaluated using a semi-quantitative scale which involved evaluating the proportion of positive cells (0-5% no reaction [], 6-25%: weak reaction [+], 26-50%: moderate reaction [++], above 50%: intense reaction [+++]). The evident deficit of ER observed in our studies might indicate an oestrogen independency of the adenocarcinomas in bitches. This, however, does not preclude involvement of the receptors at earlier stages of carcinogenesis. The obtained strong correlation between expressions of Ki-67 and that of PgR (r=0.67), in view of the high prognostic value of Ki-67 expression, confirmed in numerous studies, allow the conclusion that presence of progesterone receptors in the cells of mammary gland adenocarcinoma in bitches is linked to the augmented proliferative potential of the tumors, similarly as it has been demonstrated in mammary glands in females.
9

Zastosowanie techniki mikromacierzy tkankowych (TMA) w badaniach nad markerami nowotworowymi w rakach gruczołu piersiowego

81%
Kobierzycki C., Malinska A., Dziegiel P.
Postępy Biologii Komórki
|
2012
|
tom 39
|
nr 3
10

Udzial bialek stresowych w adaptacji wysilkowej

81%
Jethon Z., Murawska-Cialowicz E., Dziegiel P., Podhorska-Okolow M.
Postępy Biologii Komórki
|
2005
|
tom 32
|
nr 4
697-706
11

System aktywacji plazminogenu w migracji komorek

81%
Jakubiszyn E., Dziegiel P., Zabel M.
Postępy Biologii Komórki
|
2006
|
tom 33
|
nr 1
123-135
12

Expression of angiotensin II AT1 and AT2 receptors in fetal mammalian kidney

81%
Podhorska-Okolow M., Dziegiel P., Kleckowska-Nawrot J., Zabel M.
Acta Biologica Cracoviensia. Series Botanica. Supplement
|
2006
|
tom 48
|
nr 1
61
13

Role of lymphangiogenesis in lung cancer

81%
Werynska B., Dziegiel P., Jankowska R.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 3
14

Fine-tuned MMP-9 activity level is a premissive factor for induction and maintenance of LTP in hippocampal mossy fiber-CA3 pathway

81%
Wiera G., Dziegiel P., Kaczmarek L., Mozrzymas J. W.
Acta Neurobiologiae Experimentalis
|
2012
|
tom 72
|
nr 2
Matrix metalloproteinases have been implicated in physiological and pathological functions of neuronal networks. To get an insight into the specific role of protease MMP-9 in the plasticity of the mossy fiber-CA3 pathway (mf-CA3), we used field recordings to measure LTP in slices from wild type, MMP-9 KO and overexpressing (OVX) animals. Both lack of protease (KO) and its overexpression impaired the early and maintenance phase of mf-CA3 LTP (128% vs. 181% of respective baseline in KO and WT mice; and 136% vs. 189% in OVX and WT rats respectively, P<0.05). Importantly, impaired LTP in transgenic rodents could be rescued by administration of recombinant MMP-9 to the KO slices (152% of respective baseline). Moreover, autoactive MMP-9 protein application induced a stable autopotentiation of synaptic response in KO and WT mice. β-dystroglycan is a synaptic membrane protein and its MMP-mediated cleavage has been described during pathological, epileptic activity. In mf-CA3 pathway we observed a MMP-dependent significant decrease in 30 kDa β-dystroglycan digestion product as early as 5 minutes after LTP induction. Altogether, these results suggest that in mfCA3 pathway during first minutes after tetanus fine-tuned level of MMP-9 activity acts as a permissive factor for LTP establishment. Supported by Polish Ministry for Science and Higher Education grant N N401 541540.
15

Rola melatoniny w nowotworach gruczolu piersiowego, jajnika oraz endometrium

81%
Jablonska K., Zemla A., Dziegiel P.
Postępy Biologii Komórki
|
2011
|
tom 38
|
nr 1
177-194
16

Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin in the rat

81%
Dziegiel P., Surowiak P., Jethon Z., Zabel M.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 3A
790
17

Rola leptyny w patogenezie nowotworów związanych z otyłością

81%
Nowak A., Kobierzycki C., Dziegiel P.
Postępy Biologii Komórki
|
2015
|
tom 42
|
nr 2
18

Correlation between the expression of MCM-3 protein and Ki-67 antigen in mammary adenocarcinomas of dogs (short communication)

81%
Nowak M., Madej J. A., Dziegiel P.
Bulletin of the Veterinary Institute in Puławy
|
2008
|
tom 52
|
nr 4
The studies were aimed at the determination of MCM-3 expression intensity in cells of mammary adenocarcinomas in bitches using an immunohistochemical technique and at comparing the obtained results with expression intensity of Ki-67 antigen, representing an exponent of tumour cells proliferative activity. The material for the studies was sampled during surgical procedures from 16 bitches of various breeds, aging from 6 to 11 years, which developed mammary tumours. The neoplastic tumours were histopathologically verified as adenocarcinomas. Immunohistochemical reactions were performed in order to detect MCM-3 protein and Ki-67 antigen in the tumours. Microphotographs of the obtained preparations were subjected to computer-assisted image analysis using the MultiScaneBase V 14.02 software. A statistical analysis of the results demonstrated a positive, strong correlation (r = 0.57) between the expression of Ki-67 proliferation antigen and expression of MCM-3 protein in the adenocarcinomas. This may indicate the usefulness of the latter protein as a marker defining a proliferative potential of the tumour.
19

Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy

81%
Nowak M., Dziegiel P., Madej J., Ugorski M.
Folia Histochemica et Cytobiologica
|
2013
|
tom 51
|
nr 2
20

Prawdy i mity o miażdżycy u zwierząt

81%
Paslawski R., Dziegiel P., Szuba A.
Magazyn Weterynaryjny
|
2019
|
tom 28
|
nr 03
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