INTRODUCTION: Motor impairment is fundamental feature of Parkinson’s disease (PD). There are several reports on the beneficial effect of physical training on the PD symptoms reduction, however the mechanisms underlying this improvement are not known The selection of an appropriate animal model is crucial to demonstrate positive effect of physical effort on motor function, because even despite extensive loss of dopaminergic neurons the detection and quantification of motor impairment is difficult. AIM(S): The purpose of the study was to examine the efficacy of physical training in reversing the expected motor impairment in chronic MPTP mice model of parkinsonism. METHOD(S): C57BL/6 mice were treated for five weeks with 12,5 mg/kg MPTP in combination with 250 mg/kg probenecid. Mice were subdivided into: 1) control sedentary; 2) control trained (10 weeks); 3) MPTP sedentary (non-exercised with PD); 4) early trained MPTP (10 weeks: before, during, and after the induction of PD), and 5) late trained MPTP (10 weeks, started after the induction of PD). To assess motor performance rotarod, open field and inverted horizontal grid tests were performed before MPTP treatment, after the completion of intoxication and when the training was finished. RESULTS: MPTP did not impair motor function. We observed improvement of motor performance in rotarod and open field test in MPTP, early trained mice. Some enhancement of motor skills in rotarod test was observed also for MPTP non-exercised mice. In horizontal grid test the only parameter significantly influenced by MPTP treatment was the total number of touches and we did not observe the impact of physical training on the reduction of this parameter. CONCLUSIONS: We did not observe the impact of MPTP and physical training alone on motor performance in mice model of parkinsonism. However, there has been a certain improvement in some of the motor parameters in both groups of MPTP treated mice, which performed physical training. FINANCIAL SUPPORT: NCN grant 2014/15/B/ NZ4/05041
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