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Validation of relationship between milk resistance and daily yield of dairy cows

100%

Burmanczuk A., Hola P., Wojciechowska B., Kowalski C., Grabowski T.

Polish Journal of Veterinary Sciences

2017

tom 20

nr 4

Effects of flunixin and florfenicol combined with vitamins E and/or C on selected immune mechanisms in cattle under conditions of adaptive stress

86%

Urban-Chmiel R., Stachura R., Hola P., Puchalski A., Dec M., Wernicki A.

Bulletin of the Veterinary Institute in Puławy

2015

tom 59

nr 2

The aim of the study was to evaluate the effect of flunixin and florfenicol administered in combination with vitamin E or C on selected leukocyte immune mechanisms and on the inflammatory process during the first few weeks in the feedlot. Fifty calves divided into 5 groups (n = 10) received florfenicol and flunixin with vitamin E or C. Blood was collected on the 1st, 3rd , 7th , 14th , 21st , and 28th d of the experiment. Intracellular metabolism (NBT), apoptosis, Chemotaxis, susceptibility to M. haemolytica leukotoxin, and expression of ß₂-integrins were determined in leukocytes. The symptoms of respiratory tract infection were observed in 40% of calves in control group, while in the other groups the morbidity rate ranged from 10% to 20%. Leukocytes showed decreased NBT, and the mean values for apoptosis ranged from 14% to 24%. The lowest percentage of apoptotic cells was observed in the calves that received florfenicol with flunixin and vitamins E and C. The chemotactic activity confirmed the significant inhibitory effect of the preparations on migration of the cells. A significant decrease (P ≤ 0.05) in the susceptibility of leukocy tes to leukotoxin was noted in the group that received florfenicol and flunixin with vitamin E. Expression of ß₂-integrin receptors was the lowest in calves receiving florfenicol with flunixin and vitamin E or C. The application of an antibiotic and a non-steroidal anti-inflammatory drug with antioxidants protected the leukocytes involved in defence against M. haemolytica virulence factors and effectively limited oxidative stress in the calves.

Efficacy of florfenicol and flunixin followed with vitamins E and/or C on selected oxidative and inflammatory mechanisms in young cattle under transport and adaptation stress

72%

Wernicki A., Stachura R., Hola P., Puchalski A., Dec M., Stegierska D., Zurek A., Urban-Chmiel R.

Medycyna Weterynaryjna

2018

tom 74

nr 04

Bovine respiratory disease (BRD) in cattle, due to the participation of numerous viral and bacterial etiological agents, predisposition factors, and environmental stresses, is a serious health and economic problem in herds of beef cattle. Given the broad scope of the problem of respiratory syndrome and the limited immunoprophylaxis, the aim of this study was to estimate the additive effects of flunixin with florfenicol followed with vitamin E or/and C in reducing the development of oxidative stress and inflammation in the first weeks in the feedlot. The study was conducted on young Simmental cattle (n = 50) weighing approx. 160 kg. The animals were divided into 5 groups (n = 10 in each group). Group I was the control. The cattle received florfenicol and flunixin in combination with vitamins E or C (Group II and III), florfenicol and flunixin followed with vitamin E and C (Group IV), or florfenicol and flunixin without vitamins (group V). Blood for sera was collected on the day the drugs were administered and on days 3, 7, 14, 21 and 28 of the experiment. The level of oxidative stress was analysed on the basis of the concentration of nitrogen ions (NO) in the sera and of lipid peroxidation end products reacting with thiobarbituric acid (TBARS). Concentrations of haptoglobin (Hp) and serum amyloid A (SAA) in the sera were determined using EIA enzyme immunoassays. The treatment used in the study, involving the application of florfenicol and flunixin with vitamin E or C, substantially reduced the level of oxidative stress, expressed as a reduced concentration of TBARS and NO ions, particularly in groups II and III. It was also confirmed that the treatment inhibited the concentration of acute phase proteins (Hp and SAA).

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Medycyna Weterynaryjna

1 Polish Journal of Veterinary Sciences

3 Hola P.

2 Dec M.

2 Puchalski A.

2 Stachura R.

2 Urban-Chmiel R.

2 Wernicki A.

1 Burmanczuk A.

1 Grabowski T.

1 Kowalski C.

1 Stegierska D.

1 Wojciechowska B.

1 Zurek A.

1 2018

1 2017

1 2015

Wyniki wyszukiwania

Validation of relationship between milk resistance and daily yield of dairy cows

Effects of flunixin and florfenicol combined with vitamins E and/or C on selected immune mechanisms in cattle under conditions of adaptive stress

Efficacy of florfenicol and flunixin followed with vitamins E and/or C on selected oxidative and inflammatory mechanisms in young cattle under transport and adaptation stress