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Introduction. The incidence of metabolic disorders in obese people is not only determined by the amount of adipose tissue but mainly by its distribution. Metabolic disorders may lead to the development of occupational metabolic diseases. Aim of Study. The aim of the study was to estimate the effects of increased physical activity in women with abdominal obesity on carbohydrate and lipid metabolism and glucose tolerance. Material and Methods. The study was carried out on a group of 32 physically active women aged 59.1 ± 5.39 years. Somatic traits were measured and physiological and biochemical tests (VO2 max, lipid profile, glucose and insulin levels) were carried out at rest while fasting. The BMI, WHR and HOMAIR indices were calculated. Results. The following results were obtained for the sample: BMI (32.9 ± 4.57 kg/m²), WHR (0.88 ± 0.04), VO₂ max (33.6 ± 8.19 ml/kg⁻¹/min⁻¹), total cholesterol (226.3 ± 45.12 mg/dl), LDL-cholesterol (140.6 ± 37.79 mg/dl). Conclusions. The results confirm positive effects of physical activity on the lipid profile and the homeostatic model assessment insulin resistance index (HOMAIR).
Background. The main cause of the excessive deposition of fat is the destruction of the mechanisms controlling the expenditure of energy. Pathological increase of adipose tissue leads to disorders of the body, and lipid - carbohydrate parameters, promotes the development of vascular diseases and increases the risk of morbidity and mortality. The aim of the study is to demonstrate the impact of diet and physical activity changes in the parameters lipid-carbohydrate of adolescents. Material and methods. The study included obese boys (n = 35), undergoing weight re- duction. A low-energy diet and regular physical activity were applied. At the beginning and after four weeks were performed anthropometric measurements and indicators of the composition of venous blood was determined. In the venous blood was determined total cholesterol, HDL-cholesterol, triacylglycerols (TG), glucose and insulin. LDL-cholesterol was calculated. Results. It was found that the applied treatment improved the lipid profile of blood. Only for triglyceride change was not statistically significant. Statistically significant was the reduction of the concentration of glucose. Conclusions. Reduction of body mass resulted in positive changes in blood lipidogramme and reduction of waist hip ratio, which can reduce the risk of cardiovascular disease in the future. Reduction in serum insulin and glucose demonstrates improved carbohydrate metabolism and indicates a reduced risk for type II diabetes.
Obesity is associated with possible complications like hyperlipidemia, hypertension, coronary heart disease and diabetes. The aim of this study was to evaluate the effect of composite herbal extracts on blood lipids, glucose metabolism, leptin and homocystein. randomised, double-blind, placebo-controlled clinical trial on 51 overweight, healthy subjects. Preparation of nutrifin® support in a form of tablets, which is a botanical water extract composed of green tea extract, bean peels and asparagus was used. changes in lipoprotein, glucose, insulin, leptin and homocysteine failed to produce statistically significant difference. Alteration of lipid profile including: changes of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were: –9.4%, –18.7%, +11.8%, –13.4% for nutrifin® support group and –8.0%, –12.2%, +1.4% and 14.8% for placebo group, respectively. Differences between groups were not significant. The change in total cholesterol and LDL cholesterol strongly correlated with start values of total cholesterol and LDL cholesterol. The correlation coefficients were –0.92 and –0.91 (p<0.001) in active extract group, respectively. Most of researched changes in blood parameters in both groups were not significant, but the reduction in total cholesterol and LDL cholesterol was strongly correlated with lipids levels at the start of the study.
Introduction. Physical training is considered an effective means of preventing and treating diseases of affluence such as T2DM. The key benefits of this therapy include improvements in physical performance and in metabolic processes. Aim of Study. The aim of this study was to investigate the impact of a 12-week long supervised combined strength and endurance training program on physical performance of T2DM patients with various complications. Material and Methods. The study was carried out on patients stratified into Groups (levels) 2 and 3 according to the criteria from the 2007 Danish program “Forløbsprogram for Type 2 Diabetes” (see Table 1). A total of 83 patients (29 women, 54 men) participated in the study, aged 65.5 ± 10.62 years. The subjects were offered 60 minutes of supervised group exercise, twice a week for 12 weeks. Each session consisted of a 5-min warm-up, 35-min strength exercise, and 10-min aerobic bicycling, with a load between 12 and 15 on the Borg Scale. Physical performance was measured using a 30-second sit-to-stand test (STS) and 6-minute-walk test (6MWT). Results. A significant improvement in STS was noted in Group 2 (mean = 1.6 ± 2.39; 95% CI 0.92-2.3) and in Group 3 (mean = 1.46 ± 2.14; 95% CI 0.74-2.17). Statistically significant (p <0.0001) 6MWT results were obtained in Group 2 (mean = 46.7 ± 54.08; (95% CI 30-63) and in Group 3 (mean = 46.2 ± 79.51; 95% CI 12-79). Participation in training sessions played a paramount role in improving the effectiveness of combined strength and endurance training. Conclusion. Participation in a 12-week exercise program increased physical performance in patients with type 2 diabetes, regardless of their complication status.
 Background. There is an increasing interest in the role of adipocytokines in cardiovascular pathophysiology. Aim. The aim of the study was to compare visfatin levels, a novel adipokine, in patients with heart failure (HF) due to the left ventricular systolic dysfunction with those in age- and body mass index (BMI) - matched healthy controls in relation to the parameters of glucose metabolism and high sensitivity C-reactive protein (hsCRP) levels. Material/Subjects and Methods. The study population consisted of 28 males with systolic HF referred for cardiopulmonary exercise testing, divided into two subgroups based on their NYHA class (HF patients NYHAI+II, n=17, and HF patients NYHAIII+IV, n=11), and 23 controls. The following indices were measured in a serum samples: visfatin, hsCRP, glucose and lipid metabolism parameters, and the insulin resistance index HOMAIR (homeostasis model assessment insulin resistance) was calculated. Results. Concentrations of visfatin and high-density lipoprotein cholesterol (HDL-cholesterol) in the HF subjects were significantly lower (p ≤ 0.01) than in controls. The Kruskal-Wallis test showed significant differences between three groups (controls and both subgroups of heart failure patients) in mean levels of visfatin, hsCRP, glucose, HOMAIR and HDL-cholesterol. Conclusion. Serum visfatin concentrations in patients with systolic HF, particularly with more advanced NYHA classes, are significantly lower in comparison to healthy controls and are independent of age or anthropometric and metabolic parameters.
The results of recent studies indicate that obesity is associated with an increase in peroxidation processes. The aim of the present study was to assess the degree of oxidative stress in obese women and to evaluate the relationship between selected markers of oxidative stress and body mass index. Study population consisted of 43 women aged 21 to 66. Subjects were divided into two groups according to their body mass index (BMI): Overweight group (BMI < 30 kg/m2) and Obese group (BMI > 30 kg/m2). Venous blood samples were taken from each subject after an overnight fast and following parameters were assessed: plasma total antioxidant status (TAS), plasma concentrations of thiobarbituric acid reactive substances (TBARS), serum levels of antibodies against oxidized low density lipoproteins (oLAB), serum lipid profiles, serum glucose and insulin concentrations. Additionally, serum low density lipoprotein (LDL) cholesterol and insulin resistance indices were calculated. Serum triglyceride concentrations, insulin levels and insulin resistance indices were significantly higher in obese women in comparison with overweight ones. No significant differences in TBARS concentrations, TAS and oLAB levels were found between the two study groups. However, oLAB titres in Obese group were above the upper limit of the reference range for healthy adults. In both study groups significant correlations (p <0.01) between BMI and levels of triglycerides, insulin concentrations and insulin resistance indices were observed. Additionally, positive correlations (p < 0.05) between BMI and LDL-cholesterol and diastolic blood pressure as well as negative correlations (p < 0.05) between HDL-cholesterol and diastolic blood pressure were found in Obese group. In the overweight women, there were positive correlations between oLAB levels and triglyceride and insulin concentrations, between oLAB titres and insulin resistance indices and between oLAB levels and systolic and diastolic blood pressure (p < 0.01 for all correlations). There was also a negative correlation between oLAB titres and TAS (p < 0.05). The results of the present study confirm that obesity is associated with oxidative stress. Oxidative stress may be the link between obesity and atherosclerosis.
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