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Spatial and temporal changes of osteopontin in oxygen-glucose-deprived hippocampal slice cultures

100%

Lee J.-Y., Choi J.-S., Choi J.-Y., Shin Y.-J., Yun H., Cha J.-H., Chun M.-H., Lee M.-Y.

Acta Neurobiologiae Experimentalis

2010

tom 70

nr 1

We have examined the temporal changes and cellular localization of osteopontin (OPN) mRNA and protein in organotypic hippocampal slice cultures subjected to ischemia-like oxygen–glucose deprivation (OGD). The sequential induction pattern of OPN expression occurred in a time- and cell-dependent manner in hippocampal slice cultures after OGD. The early response consisted of neuronal and microglial OPN upregulation, followed by a later extended phase of expression in reactive astrocytes. OPN immunoreactivity after OGD matched the mRNA induction patterns. Activated microglia revealed OPN staining in focal deposits, whereas neurons and reactive astrocytes showed perinuclear staining with a punctate cytosolic pattern of OPN, typical of secreted proteins. These data demonstrated that the temporal and cellular patterns of OPN induction in reactive glial cells in this in vitro model closely correlated with that in the in vivo model, suggesting that OPN has a multifunctional role in the pathogenesis of ischemic injury.

Effects of sodium tripolyphosphate on oral commensal and pathogenic bacteria

100%

Moon J.-H., Noh M. H., Jang E.-Y., Jang S. B., Kang S. W., Kwack K. H., Ryu J.-I., Lee J.-Y.

Polish Journal of Microbiology

2019

tom 68

nr 2

Three concurrent variations of the aberrant right subclavian artery, the non-recurrent laryngeal nerve and the right thoracic duct

100%

Lee J.-Y., Won D.-Y., Oh S.-H., Hong S.-Y., Woo R.-S., Baik T.-K., Yoo H.-I., Song D.-Y.

Folia Morphologica

2016

tom 75

nr 4

We herein report a case showing three anatomical variations including the aberrant right subclavian artery (ARSA), the non-recurrent laryngeal nerve (NRLN) and the right thoracic duct in a 59-year-old male cadaver. The right subclavian artery (RSA) arose from the descending aorta next to the left subclavian artery and coursed in between the oesophagus and the thoracic vertebrae. The recurrent laryngeal nerve did not coil around the RSA but directly entered the larynx. Lastly the thoracic duct terminated into the right brachiocephalic vein. This study makes an embryological assumption that the abnormal development of the RSA had happened first and subsequently caused NRLN and the thoracic duct drainage variation. As to our knowledge, only two reports have been made previously concerning such concurrent variations. Therefore, this case report alerts anatomists and clinicians to the possibility of simultaneous occurrence of ARSA, NRLN and the right thoracic duct. (Folia Morphol 2016; 75, 4: 560–564)

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Folia Morphologica

1 Polish Journal of Microbiology

3 Lee J.-Y.

1 Baik T.-K.

1 Cha J.-H.

1 Choi J.-S.

1 Choi J.-Y.

1 Chun M.-H.

1 Hong S.-Y.

1 Jang E.-Y.

1 Jang S. B.

1 Kang S. W.

1 Kwack K. H.

1 Lee M.-Y.

1 Moon J.-H.

1 Noh M. H.

1 Oh S.-H.

1 Ryu J.-I.

1 Shin Y.-J.

1 Song D.-Y.

1 Won D.-Y.

1 Woo R.-S.

1 Yoo H.-I.

1 Yun H.

1 2019

1 2016

1 2010

Wyniki wyszukiwania

Spatial and temporal changes of osteopontin in oxygen-glucose-deprived hippocampal slice cultures

Effects of sodium tripolyphosphate on oral commensal and pathogenic bacteria

Three concurrent variations of the aberrant right subclavian artery, the non-recurrent laryngeal nerve and the right thoracic duct