Wyniki wyszukiwania

1

Chronic prymitywnie! Ochronna strefa genetycznej bioroznorodnosci rolniczej wokol parkow narodowych

100%

Budzynski A.

Ekopartner

|

1998

|

nr 01

30-31

2

Na miare srodowiska - przeciw koncentracji

100%

Budzynski A.

Ekopartner

|

2000

|

nr 01

25-26

3

Arboretum z lokalnych odmian drzew owocowych i krzewow

75%

Budzynski A.

Ekopartner

|

2002

|

nr 12

18

4

Przerób gryki na kaszę prażoną

63%

Beski S., Budzynski A.

Przegląd Zbożowo-Młynarski

|

1966

|

tom 10

|

nr 05

5

Przygotowanie mas ściernych stosowanych w młynach i kaszarniach

63%

Beski S., Budzynski A.

Przegląd Zbożowo-Młynarski

|

1966

|

tom 10

|

nr 10

6

Wplyw wybranych czynnikow na stan zdrowotny wymion krow z gospodarstw sektora publicznego

51%

Borkowska D., Janus E., Budzynska J., Budzynski A.

Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica

|

2000

|

tom 18

7

Morphometric measurements of several parameters of rat epidermis after a 28-day period of vitamin A derivative [etretinate] administration and a 28-day pause

51%

Budzynska B., Jedrych M., Budzynski A.

Folia Histochemica et Cytobiologica

|

1999

|

tom 37

|

nr 2

8

Ekologiczne sumienie

50%

Budzynski A.

Ekopartner

|

1999

|

nr 02

30-31

10

The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication - an electrogastrographic study

39%

Budzynski A., Dobrzynski A., Lorens K., Konturek P. C., Thor P., Konturek S. J.

Journal of Physiology and Pharmacology

|

2002

|

tom 53

|

nr 2

Cholecystokinin (CCK) plays an important role in the regulation of postprandial gastric motor activity which was found to be abnormal in duodenal ulcer patients. This study was designed to compare the influence of CCK on gastric myoelectrical function in duodenal ulcer patients and healthy controls. Fifteen patients with active duodenal ulcer and Helicobacter pylori (H. pylori) infection and 15 healthy controls were included into this study. Electrogastrography (EGG) was performed before and 4 weeks after the eradication of H. pylori in ulcer patients and in healthy controls. We compared EGG parameters in the fasting and postprandial period and during intravenous infusion of caerulein, an analog of CCK with or without addition of loxiglumide, a specific CCK-1 receptor antagonist. The amplitude of fasting EGG in duodenal ulcer patients was similar to that in control subjects and was not affected by H. pylori eradication. In contrast, the amplitude of postprandial EGG was markedly increased in duodenal ulcer patients when compared to that in healthy controls and it was significantly reduced following the eradication of H. pylori. The blockade of CCK-1 receptors with loxiglumide in healthy controls or H. pylori eradicated ulcer patients significantly enhanced postprandial EGG amplitude almost to the level observed in the infected duodenal ulcer patients, but failed to affect this amplitude in ulcer patients. Exogenous caerulein, an analog of CCK, failed to affect EGG amplitude in duodenal ulcer patients with H. pylori infection, but it reduced significantly EGG amplitude in these patients after H. pylori eradication and in control subjects. This inhibitory effect of caerulein in H. pylori negative ulcer patients and healthy controls was abolished by the addition of loxiglumide. Ulcer patients showed significant dysrhythmia with tachygastria up to 20% of the recording time both under basal conditions and postprandially and H. pylori eradication was followed by a significant decrease in tachygastria to about 5%, the value being similar to that in healthy controls. We conclude that the amplitude and frequency of gastric myoelectrical activity are enhanced in duodenal ulcer patients and impaired in response to CCK but these changes can be normalized by successful H. pylori eradication.

11

The reinfection of H.pylori two years after quadruple therapy for duodenal ulcer

39%

Bobrzynski A., Budzynski A., Bielanski W., Kaminska A., Gedliczka O., Konturek S. J., Stachura J.

Journal of Physiology and Pharmacology. Supplement

|

1997

|

tom 48

|

nr 1

12

Arterial structure and function and its short- and long-term changes after bariatric surgery

33%

Gluszewska A., Gryglewska B., Rewiuk K., Zarzycki B., Dzieza-Grudnik A., Kwater A., Major P., Budzynski A., Gasowski J., Grodzicki T.

Journal of Physiology and Pharmacology

|

2019

|

tom 70

|

nr 6

13

Cyclooxygenase-2 [COX-2] is the key event in pathophysiology of Barrett's esophagus. Lesson from experimental animal model and human subjects

33%

Majka J., Rembiasz K., Migaczewski M., Budzynski A., Ptak-Belowska A., Pabianczyk R., Urbanczyk K., Zub-Pokrowiecka A., Matlok M., Brzozowski T.

Journal of Physiology and Pharmacology

|

2010

|

tom 61

|

nr 4

409-418

Mixed reflux of the gastroduodenal contents induces the esophageal mucosal damage and inflammation progressing chronic esophagitis and premalignant Barrett's esophagus (BE). The role of cyclooxygenase-2 (COX-2) and chronic inflammation in the progression of BE toward adenocarcinoma of the esophagus has not been extensively studied in experimental models of BE in animals and in human subjects. We evaluated the expression of COX-2 in rat model of BE and examined the usefulness of COX-2 expression in determining the risk of malignant transformation in patients with BE treated with argon plasma coagulation (APC) that allows for effective ablation of metaplastic mucosa (group A) without or with proton pump inhibitors (PPI). In addition, the group B of patients was subjected to laparoscopic Nissen's fundoplication and group K that served as control, received PPI treatment only. Expression of COX-2 was evaluated in fresh-frozen biopsy specimens obtained from the distal esophagus in all 60 patients before and 12 months after treatment. In experimental studies, eighty rats were surgically prepared with esophagogastroduodenal anastomosis (EGDA) resulting in chronic esophagitis. At 4 months, the esophageal damage in EGDA rats was evaluated by macroscopic and histological index score, the plasma IL-1ß and TNF- levels was determined by ELISA and the mucosal expression of COX-2 mRNA and COX-2 protein were assessed by RT-PCR and Western Blot, respectively. Chronic esophagitis was developed in all EGDA animals followed by the rise in the plasma TNF- and IL-1ß levels. Histology revealed extensive esophageal ulcerations with development of columnar epithelium, formation of mucus glands in squamous epithelium, intestinal metaplasia distant to anastomosis consisting of goblet cells, infiltration of inflammatory cells including plasma cells and lymphocytes. COX-2 mRNA was absent in the esophageal mucosa of sham-control animals but strongly upregulated in metaplastic Barrett's epithelium. In BE patients, the overexpression of COX-2 was documented in patients with dysplasia. After APC (group A) or Nissen's fundoplication (group B), the expression of COX-2 mRNA was markedly reduced and these effects were positively correlated with histopathological findings. Controls failed to show significant alterations in COX-2 expression. We conclude that 1) EGDA rats serve as the suitable model of the chronic esophagitis by the gastrointestinal refluxate resembling many features of those observed in human Barrett's esophagus, as confirmed by severe morphology changes, excessive release of proinflammatory cytokines TNF- and IL-1ß and overexpression of COX-2, and 2) the significant correlation of the degree of COX-2 overexpression with histopathological findings indicates the usefulness of this inducible biomarker as a valuable indicator of the risk of malignant transformation in patients with BE.

14

Ekologiczne sumienie

32%

Budzynski A.

Aura

|

2014

|

nr 10

Ograniczanie wyników

Chronic prymitywnie! Ochronna strefa genetycznej bioroznorodnosci rolniczej wokol parkow narodowych

Na miare srodowiska - przeciw koncentracji

Arboretum z lokalnych odmian drzew owocowych i krzewow

Przerób gryki na kaszę prażoną

Przygotowanie mas ściernych stosowanych w młynach i kaszarniach

Wplyw wybranych czynnikow na stan zdrowotny wymion krow z gospodarstw sektora publicznego

Morphometric measurements of several parameters of rat epidermis after a 28-day period of vitamin A derivative [etretinate] administration and a 28-day pause

Przeciw spalaniu slomy

Ekologiczne sumienie

The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication - an electrogastrographic study

The reinfection of H.pylori two years after quadruple therapy for duodenal ulcer

Arterial structure and function and its short- and long-term changes after bariatric surgery

Cyclooxygenase-2 [COX-2] is the key event in pathophysiology of Barrett's esophagus. Lesson from experimental animal model and human subjects

Ekologiczne sumienie