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  1. 5 Annals of Animal Science

  2. 5 Bulletin of the Veterinary Institute in Puławy

  3. 4 Medycyna Weterynaryjna

  4. 4 Pasze Przemysłowe

  5. 3 Journal of Pre-Clinical and Clinical Research

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  1. 31 Dobrowolski P.

  2. 20 Tomaszewska E.

  3. 13 Muszynski S.

  4. 4 Arciszewski M. B.

  5. 4 Gawron A.

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  1. 3 2020

  2. 7 2019

  3. 4 2017

  4. 2 2016

  5. 1 2015

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1

Nie wykorzystana szansa

100%
Dobrowolski P.
Aura
|
1993
|
nr 02
4-5
The new law on nature protection, issued by the Polish Parliament in 1991 autumn, has not evoked much response, lost in a deluge of other laws, and election campaign diverted public attention. It is, nevertheless, a legal act of great importance, pertaining to preservation of reserves indispensable to the survival of the society. This law affecting over 22 per cent of Poland's area (national parks, reserves, landscape, parks, park protective zones and protected landscape areas) met with criticisms regarding details as well as general principles. Ignoring basic changes in Poland, increasing role of local authorities, development of market economy based on private ownership and entrepreneurship met with the strongest objections. The author draws attention to restrictive and bureaucratic nature of the law, but he also makes concrete objections.
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The weaning-related changes in amino acids status of blood plasma in piglets

63%
Dobrowolski P., Sliwa E.
Journal of Pre-Clinical and Clinical Research
|
2008
|
tom 02
|
nr 1
3

Maternal glucocorticoid treatment as a model for examining foetal gender-specific effects on the bone metabolism of neonatal piglets

63%
Tomaszewska E., Dobrowolski P.
Bulletin of the Veterinary Institute in Puławy
|
2012
|
tom 56
|
nr 2
The aim of the study was to investigate gender-specific effects of a maternal treatment with dexamethasone (DEX) at multiple maximum therapeutic doses during the last 25 d of pregnancy on the bone tissue metabolism in neonatal piglets. BMD and BMC were measured. The geometry, histomorphometry, and mechanical properties of bones were determined. The assessment of selected hormones, cytokines, and amino acids was performed in 35-day-old piglets. DEX administered prenatally inhibited neonatal bone development, as well as bone mineral density, and geometrical and mechanical properties of bones. Neonatal GC-induced bone loss was linked with disturbed somatotropic axis function and decreased serum concentration of GH in male piglets and decreased concentration of IGF-1 in females. Prenatal DEX treatment led to an increase in the concentration of insulin and enhanced activity of bone specific alkaline phosphatase in piglets of both genders.
4
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Content available

Prenatal glucocorticoids can programme postnatal development

63%
Tomaszewska E., Dobrowolski P.
Journal of Pre-Clinical and Clinical Research
|
2011
|
tom 05
|
nr 1
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Alpha-ketoglutarate partially protects newborns from metabolic changes evoked by chronic maternal exposure to glucocorticoids

51%
Sliwa E., Dobrowolski P., Tatara M. R., Pierzynowski S. G.
Journal of Pre-Clinical and Clinical Research
|
2007
|
tom 01
|
nr 1
6
Content available remote

Postnatal administration of 2-oxoglutaric acid improves articular and growth plate cartilages and bone tissue morphology in pigs prenatally treated with dexamethasone

51%
Tomaszewska E., Dobrowolski P., Wydrych J.
Journal of Physiology and Pharmacology
|
2012
|
tom 63
|
nr 5
7

Alterations in intestinal and liver histomorphology and basal hematological and biochemical parameters in relation to different sources of dietary copper in adult rats

51%
Tomaszewska E., Dobrowolski P., Kwiecien M.
Annals of Animal Science
|
2017
|
tom 17
|
nr 2
8

Changes of a non-specific defence mechanism in blood serum of piglets induced by prenatal and postnatal administration of alpha-ketoglutarate

51%
Sliwa E., Dobrowolski P., Siwicki A. K., Pierzynowski S. G.
Bulletin of the Veterinary Institute in Puławy
|
2007
|
tom 51
|
nr 2
The aim of this study was to establish the influence of α-ketoglutarate (AKG), administered to pregnant sows from the 91st d of pregnancy to farrowing, and then to piglets from birth to the 30th d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14th and 30th d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d of their postnatal life. Administration of AKG to sows during pregnancy increased lysozyme activity in piglets at the age of the 30th d, which reached the value 7.07 mg/L, while that in the controls was 3.90 mg/L. Ceruloplasmin activity decreased during the first 14 d of life in piglets that received AKG as a continuation of the prenatal procedure. At the age of 14 d, ceruloplasmin activity decreased to 90.96 IU/L in comparison with the 117.95 IU/L of the controls, while the level of total protein was higher (71.83 g/L) than that of the controls (64.23 g/L). There is still limited information about the relationship between exposure to AKG during foetal, and/or early postnatal life and altered postnatal immune function in piglets.
9

Ochronne działanie Povexu na scianę jelita

45%
Dobrowolski P., Gawron A., Kruszewska D., Huet P., Pierzynowski S. G.
Żywienie Człowieka i Metabolizm
|
2009
|
tom 36
|
nr 2
419-424
Przetwarzana żywność zawiera niekiedy substancje toksyczne powstające w czasie jej termicznej obróbki. Do substancji takich należy m.in. akryloamid. Celowym wydaje się więc poszukiwanie substancji, które dodane do żywności mogą ograniczać lub neutralizować niekorzystne działanie akryloamidu. Celem pracy było zbadanie czy preparat włókna ziemniaczanego (Povex) może chronić jelito cienkie przed oddziaływaniem akryloamidu. Przeprowadzono 3-miesięczne doświadczenie na samcach myszy BALB. Myszy otrzymywały akryloamid lub akryloamid i preparat włókna ziemniaczanego (Povex). Akryloamid podawano w wodzie do picia. Preparat włókna ziemniaczanego stanowił 2% dodatek do paszy. Szczegółowemu badaniu poddano jelito cienkie, z wycinków którego sporządzono preparaty histologiczne. Mikroskopowe obrazy ściany jelita poddano analizie histomorfometrycznej. Oznaczono także we krwi poziom adduktów akryloamidu z hemoglobiną. Przyjmowany przez myszy akryloamid w dawce 0,5 mg/kg mc/dzień nie miał wpływu na masę ciała ani konsumpcję wody, czy paszy. Akryloamid wywoływał natomiast zmiany w budowie ściany jelita. Stwierdzono różnice w grubości błony śluzowej, podśluzowej i mięśniowej. Największe zmiany zanotowano w błonie śluzowej. Dotyczyły one nabłonka, wnętrza kosmków oraz gruczołów jelitowych. Zmniejszyła się liczba komórek dzielących się, wzrosła natomiast ilość komórek apoptotycznych. Powstałe zmiany spowodowały zmniejszenie powierzchni wchłaniania jelita. Budowa jelita myszy otrzymujących akryloamid i Povex nie wykazywała takich zmian. Oceniane parametry ściany jelita były podobne do kontroli. Stwierdzono natomiast wzrost powierzchni wchłaniania jelita. Jednakowa ilość adduktów akryloamidu z hemoglobiną we krwi obydwu grup otrzymujących akryloamid wskazuje, że Povex nie wpływa na przechodzenie akryloamidu przez barierę jelitową. Preparat włókna ziemniaczanego redukuje oddziaływanie akryloamidu na ścianę jelita cienkiego. Povex może być zatem brany pod uwagę jako dodatek do żywności zmniejszający toksyczny wpływ akryloamidu.
10

Cell death and neuronal arborization upon quercetin treatment in rat neurons

45%
Jakubowicz-Gil J., Rzeski W., Zdzisinska B., Dobrowolski P., Gawron A.
Acta Neurobiologiae Experimentalis
|
2008
|
tom 68
|
nr 2
Quercetin, one of the major flavonoids, exhibits many beneficial effects on human organism as antihistamine, antioxidant, anti-inflammatory, anticancer and antiviral drug. It is recommended as suplement of healthy diet but still the knowledge of its beneficial effect on normal cells is not satisfactory. We decided to examine the effect of flavonoid on neurons morphology and their susceptibility to cell death. Fractal analysis of rat neurons revealed that 24 hours long incubation with quercetin diminished neuronal arborisation in cortical neurons. Neurons also appeared to be very sensitive to cell death after flavonoid treatment in concentration dependent manner. Over 50% of cells died after incubation with 15 μg/ml of flavonoid while 1 μg/ ml of quercetin induced cell death only in 5%. Staining with Hoechst 33342 and propidium ioidide revealed the two types of cell death: apoptosis and necrosis. The number of apoptotic cells was comparable with necrotic ones. These results suggest toxic effect of quercetin on neurons what should be taken into consideration in further studies on using quercetin as therapeutic agent.
11

Comparison of the effect of a standard inclusion level of inorganic zinc to organic form at lowered level on bone development in growing male Ross broiler chickens

45%
Tomaszewska E., Dobrowolski P., Kwiecien M., Wawrzyniak A., Burmanczuk N.
Annals of Animal Science
|
2016
|
tom 16
|
nr 2
12

Preliminary study of time-dependent influence of maternal nutrition with addition of beta-hydroxy- beta -methylbutyrate on the body weight and selected organs weight in the new-born spiny mice (Acomys cahirinus) offspring

45%
Muszynski S., Tomczyk A., Dobrowolski P., Tomaszewska E., Hulas-Stasiak M.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2016
|
tom 19
|
nr 4
13

Acrylamide-induced prenatal programming of bone structure in mammal model

45%
Tomaszewska E., Dobrowolski P., Puzio I., Donaldson J., Muszynski S.
Annals of Animal Science
|
2020
|
tom 20
|
nr 4
14

Alterations of liver histomorphology in relation to copper supplementation in inorganic and organic form in growing rats

39%
Tomaszewska E., Dobrowolski P., Kwiecien M., Burmanczuk N., Badzian B., Szymanczyk S., Kurlak P.
Bulletin of the Veterinary Institute in Puławy
|
2014
|
tom 58
|
nr 3
The aim of this study was to define the effects of diet containing the same mineral content of mineral salt or amino acid chelate, and diet containing various levels of Cu amino acid chelate on liver histomorphometry in growing rats. Male Wistar rats were used in the 12th week experiment. The control group (n = 12) was fed standard diet, which provided Cu in an inorganic form at the level required for rats. The experimental animals were divided into four groups (each n = 12) depending on different levels ( 100%, 75%, 50%, 25% covered daily demand) of Cu supplementation in chelated form. Cu content was determined in the liver tissue and blood plasma. Immunohistochemical staining with caspase-3 antibody was performed. Microscopic assessment of the liver structure indicated that Cu supplementation did not change the liver architecture. However, histomorphometric analysis revealed a significant increase in the number of nuclei, total cell number, and multinucleated hepatocytes in rats supplemented with the organic form of Cu at the level of 25% compared with the control group. There was a considerable increase in the number of apoptotic cells and ballooning degeneration of hepatocytes, especially in groups supplemented with organic form of Cu covering the daily demand in 100% and 75%, in comparison to control group. Moreover, there was no Cu deposition in the liver and changes in Cu content in blood. Cu provided in the diet in organic form covering an amount of its minimum daily demand in 25% appears to be the least harmful with regard to the liver. It indicates that there is a need to establish the level of diet supplementation with Cu amino acid chelates.
15

Wplyw agonisty receptorow adrenegicznych beta2-clenbuterolu na mineralizacje kosci piszczelowej szczura w warunkach ustalonej osteopenii

39%
Radzki R. P., Bienko M., Kapica M., Puzio I., Dobrowolski P., Filip R.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 07
824-826
The purpose of the study was to determine the effect β₂-adrenergic receptor agonist-clenbuterol on tibiae mineralization of female rats with established osteopenia. The experiments were conducted on 30 female 3-months-of-age Wistar rats with an initial body weight of about 250 g. The sham-operation - SHO (n=10) and bilateral ovariectomy - OVX (n=20) were performed. After 60 days of osteopenia induction the ovariectomized rats were divided into a group fed a standard diet (n=10) and a group that received a diet supplied with clenbuterol at a dose of 5 mg/kg. After 14 days of the experiment the tibiae was isolated and tested using a DEXA densitometer, peripheral quantitative computer tomography (pQCT) and three-point bending test. The obtained results proved that a 14 day period of clenbuterol treatment significantly increased mechanical properties content and mineral density, both planar (BMD) and volumetric (vTotBMD) of the tibiae of ovariectomized rats.
16

Ocena bezpieczeństwa jodoforowego środka dezynfekującego na przewód pokarmowy i układ kostny zwierząt nieprzeżuwających

39%
Tomaszewska E., Muszynski S., Dobrowolski P., Ivashkiv Y., Rudyk H., Brezvyn O., Kotsyumbas I.
Pasze Przemysłowe
|
2019
|
tom 28
|
nr 1
17

Wpływ stosowania jodoforowo-krzemianowego preparatu dezynfekcyjno-absorbującego na wyniki testów czynnościowych wątroby, strukturę jelita cienkiego oraz parametry kości szczura

39%
Muszynski S., Dobrowolski P., Ivashkiv Y., Rudyk H., Brezvyn O., Kotsyumbas I., Paszkiewicz W.
Medycyna Weterynaryjna
|
2019
|
tom 75
|
nr 11
The aim of the study was to assess the risk of using an iodophor disinfecting and cleaning agent based on clinoptilolite intended for dry disinfection in the presence of non-ruminants. In a rat model study, a suspension containing 103.3 mg/kg b. w. of the disinfectant (a dose of 0.1 of LD50) was administrated per os for a period of 21 days. Its toxicity was assessed on the basis of liver function tests. The effects of the disinfectant on the histological parameters of the duodenum and jejunum and on the properties of long bones were determined. Although the agent showed no toxicity, at the end of the experiment the experimental animals had lower body weights than the control group animals (P < 0.01). The disinfectant exerted an adverse effect on the histological parameters of the jejunum, reducing the length of the intestinal villi (P < 0.01) and the absorption area (P < 0.05) and increasing the crypt depth (P < 0.05). On the other hand, the presence of clinoptilolite positively influenced the parameters of long bones, increasing their mass (P < 0.001), length (P < 0.001), density (P < 0.01), and ash content (P < 0.01). In the bone metaphysis and epiphysis root, a significant increase was found in the trabecular bone volume (P < 0.001) and the trabecular number (P < 0.05). Bone fracture strength was also increased (P < 0.05) in the experimental animals. The results obtained show that iodophores and clinoptilolite can be used in veterinary practice as components of low-toxic disinfecting and absorbing agents. However, the reduced body mass of the experimental animals suggests the need for further comprehensive tests aimed at determining the amount of the iodophor disinfecting and cleaning agent that does not impair performance parameters.
18

Regulation of folliculogenesis by growth factors in piglet ovary exposed prenatally to beta-hydroxy-beta-methylbutyrate (HMB)

39%
Hulas-Stasiak M., Jakubowicz-Gil J., Dobrowolski P., Grzesiak M., Muszynski S., Swiatkiewicz M., Tomaszewska E.
Annals of Animal Science
|
2020
|
tom 20
|
nr 3
19

Dose-dependent influence of dietary cu-glycine complex on bone and hyaline cartilage development in adolescent rats

39%
Tomaszewska E., Dobrowolski P., Kwiecen M., Winiarska-Mieczan A., Tomczyk A., Muszynski S., Gladyszewska B.
Annals of Animal Science
|
2017
|
tom 17
|
nr 4
20

Influence of oral administration of HMB to pregnant dams on calbindin expression in the dentate gyrus of the hippocampus during postnatal development in spiny mice offspring

39%
Rycerz K., Krawczyk A., Jaworska-Adamu J., Szalak R., Tomaszewska E., Dobrowolski P.
Medycyna Weterynaryjna
|
2017
|
tom 73
|
nr 06
The aim of the study was to investigate the morphology, density and immunostaining intensity of calbindin (CB)-positive neurons of dentate gyrus (DG) in new-born (P0) and 21-day-old (P21) male Acomys cahirinus mice from dams receiving β-hydroxy-β-methylbutyrate (HMB) during pregnancy. Different substances administrated to pregnant dams may affect the calcium ion homeostasis which is crucial for the proper brain development of their offspring. DG with hilus (H) plays an important role in memory and learning processes. Calcium levels in DG are regulated by buffering proteins like calbindin D28k (CB). Experimental dams were orally treated with HMB at a dose of 0.2 g/kg b.w. Half of new-born animals were euthanised after birth and the rest after the 21st day of life. The brains were dissected and embedded in paraffin blocks using a routine histological technique. In order to demonstrate CB protein expression an immunohistochemical peroxidase-antiperoxidase reaction was conducted. The results of the study did not reveal important morphological alterations. There were no statistically significant changes in the density of the studied cells either in P0 and P21 animals. However, the authors have demonstrated a statistically significant increase of the average CB-immunostaining intensity in nuclei and cytoplasm in both age groups. It may be a result of a compensation effect to alterations that occurred under the influence of HMB. On the basis of the conducted research, it may be assumed that HMB activity in DG may provide long-term consequences.
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