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Impact of carbon centered free radical chemistry on proapoptotic function of ButOOH in rat thymocytes

100%

Syta E., Kossowska E., Zauszkewicz A., Kedzior J., Zurawa D., Wozniak M.

Acta Biochimica Polonica

2003

tom 50

nr Supplement 1

Oxidative stress dependent antiproliferative activity of 2-methoxyestradiol

100%

Zauszkiewicz A., Syta E., Gil A., Kedzior J., Spodnik J., Wozniak M.

Acta Biochimica Polonica

2003

tom 50

nr Supplement 1

4-OH-TEMPO prevents the morphological alteration of rat thymocytes primed to apoptosis by oxidative stress inducer ButOOH

68%

Kossowska E., Zauszkiewicz A., Kubasik-Juraniec J., Tukaj C., Spodnik J. H., Hallman A., Klimek J., Syta E., Figarski A., Wakabayashi T., Wozniak M.

Folia Morphologica

2004

tom 63

nr 3

Thymocytes exposed to the pro-oxidant tert–butyl-hydroperoxide (ButOOH) display a number of dramatic changes in morphology similar to those observed in the case of dexamethasone-treated cells. Both reagents induce nuclear chromatin peripheral aggregation below the nuclear membrane. Some nuclei themselves break up producing two or more fragments. ButOOH-treated cells are morphologically characterised by cell shrinkage, extensive surface blebbing and, finally, fragmentation into membrane–bound apoptotic bodies composed of cytoplasm and tightly packed with or without nuclear fragments. An increased level of lipid hydroxyperoxides was detected after exposure of thymocytes to ButOOH. Both oxidative stress markers and morphological damage to cells were prevented by the antioxidant 4-OH-TEMPO.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Folia Morphologica

3 Syta E.

3 Wozniak M.

2 Kedzior J.

2 Kossowska E.

2 Zauszkiewicz A.

1 Figarski A.

1 Gil A.

1 Hallman A.

1 Klimek J.

1 Kubasik-Juraniec J.

1 Spodnik J.

1 Spodnik J. H.

1 Tukaj C.

1 Wakabayashi T.

1 Zauszkewicz A.

1 Zurawa D.

1 2004

2 2003

Wyniki wyszukiwania

Impact of carbon centered free radical chemistry on proapoptotic function of ButOOH in rat thymocytes

Oxidative stress dependent antiproliferative activity of 2-methoxyestradiol

4-OH-TEMPO prevents the morphological alteration of rat thymocytes primed to apoptosis by oxidative stress inducer ButOOH