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Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist

100%

Meert T. F., De Haes P., Aerts N., Clincke G.

Acta Neurobiologiae Experimentalis

1996

tom 56

nr 4

A simple, non-invasive method for the measurement of reserpine-induced tremor in rats

88%

Meert T. F., Rombouts J., Voeten J., Naranji F., Clincke G.

Acta Neurobiologiae Experimentalis

1997

tom 57

nr 1

Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats

64%

Torremans A., Ahnaou A., Van Hemelrijck A., Straetemans R., Geys H., Vanhoof G., Meert T. F., Drinkenburg W. H.

Acta Neurobiologiae Experimentalis

2010

tom 70

nr 1

Phosphodiesterases (PDEs) form a family of enzymes involved in the hydrolysis of cyclic adenosine and guanosine monophosphate (cAMP and cGMP). PDE10A is a member of this family that is almost exclusively expressed in the striatum. Increasing cAMP/cGMP levels via inhibition of PDE10A is under consideration as a novel therapeutic avenue in the discovery of antipsychotics. Papaverine has been used as a pharmacological tool to establish the possible clinical use of PDE10A inhibitors as antipsychotics. Papaverine is known to increase cAMP levels in striatum and to decrease blood pressure, body temperature and locomotor activity after systemic administration. In this study, the effects of papaverine are compared to those of a more specific PDE10A inhibitor MP10. Papaverine raised striatal cAMP levels with hypothermia, hypoactivity and decreased cardiovascular responses. The more selective MP10 had significantly less effects on body temperature and cardiovascular functions, but reduced locomotor activity to a similar extend as papaverine.

Ograniczanie wyników

3 Acta Neurobiologiae Experimentalis

3 Meert T. F.

2 Clincke G.

1 Aerts N.

1 Ahnaou A.

1 De Haes P.

1 Drinkenburg W. H.

1 Geys H.

1 Naranji F.

1 Rombouts J.

1 Straetemans R.

1 Torremans A.

1 Van Hemelrijck A.

1 Vanhoof G.

1 Voeten J.

1 2010

1 1997

1 1996

Wyniki wyszukiwania

Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist

A simple, non-invasive method for the measurement of reserpine-induced tremor in rats

Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats