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Role of the afferent vagal pathway in modelling of cardio-respiratory response to arvanil in anaesthetized rats

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Kopczynska B.

Acta Neurobiologiae Experimentalis

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2009

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tom 69

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nr 3

Arvanil is metabolically stable hybrid between anandamide and capsaicin and an agonist of cannabinoid CB1 and vanilloid VR1 receptors. Arvanil is able to alleviate hyperkinesia typical in rat model of Huntington’s disease, spasticity, pain, tremor and other signs of disease in rat model of multiple sclerosis. The drug reveals anti-tumour and anti-infl ammatory action. The present study was designed to test the role of the vagal pathway in post-arvanil cardiorespiratory response. Cardio-respiratory effects of an intravenous injection of arvanil were investigated in 21 urethane-chloralose anaesthetised and spontaneously breathing rats. Bolus injection of 0.8 mg kg-1 of arvanil into the right femoral vein induced in all neurally intact rats a signifi cant increase of tidal volume (VT) and diaphragm activity as well as hypertension coupled with fall in respiratory rate (f). Bilateral midcervical vagotomy precluded the alteration of respiratory parameters without any changes in cardiovascular effects. Arvanil-induced increase in mean arterial blood pressure (MAP) still persisted even after supranodose vagotomy. Results indicated that the respiratory effects evoked by arvanil administered via the peripheral circulation require intact midcervical vagi. Supranodose vagotomy failed to eliminate the hypertension evoked by arvanil.

2

Wpływ kanabinoidów na kształtowanie odpowiedzi oddechowo-ciśnieniowej w modelu zwierzęcym

100%

Kopczynska B.

Medycyna Weterynaryjna

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2011

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tom 67

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nr 09

Cannabinoids, the active components of Cannabis sativa, and their derivatives produce a wide spectrum of physiological effects mediated by two different types of receptors: G protein coupled cannabinoid receptor CB1 and transient receptor potential vanilloid type 1 (TRPV1). The afferent vagal pathway modulates the cardio-respiratory response to cannabinoids. The present article summarizes the cardio-respiratory effects of selected cannabinoids: endogenous anandamide and a novel drug arvanil, a metabolically stable hybrid between anandamide and capsaicin. An intravenous administration of anandamide in rats induces apnoea coupled with hypotension and evokes the decrease in the tidal volume at the early phase of reinitiated breathing. The inhibition of respiration and depression of blood pressure produced by anandamide are mediated via vagal peripheral input to the respiratory center in the medulla, while the nodose ganglia are essential in the observed phenomena. Post-anandamide apnoea and hypotension are mediated by both TRPV1 and CB1 receptors but the decline of tidal volume evoked by anandamide might depend on receptors of a different type. An administration of arvanil produced an increase of tidal volume and diaphragm activity, hypertension coupled with a fall in respiratory rate. The post-arvanil rise of tidal volume was mediated by both TRPV1 and CB1 receptors. Only vanilloid receptors seemed to be involved in the increase of diaphragm activity and decrease of respiratory frequency. Hypertensive response to arvanil might depend on receptors of a different type. The respiratory effects elicited by arvanil require intact midcervical vagi. Supranodose vagotomy failed to eliminate the hypertension evoked by arvanil. This implies that post-arvanil hypertension could be co-mediated by both vagal and extravagal pathways. The mechanism of cardio-respiratory effects of cannabinoids is worth exploring on account of their anti-tumor and anti-inflammatory actions and the possible usage of cannabinoids and their derivatives as drugs.

3

Ventilatory response to intracarotid serotonin challenge in cats

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Kopczynska B., Szereda-Przestaszewska M.

Acta Neurobiologiae Experimentalis

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1997

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tom 57

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nr 5

4

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Apnoeic responses to pulmonary and systemic challenge of capsaicin in cats

63%

Kopczynska B., Szereda-Przestaszewska M.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 1

5

Apnoeic responses to intracarotid nicotine challenge in anaesthetized cats

63%

Szereda-Przestaszewska M., Kopczynska B.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 2

To determine the effects of an intraarterial administration of nicotine on the occurrence of apnoea and the activity of rib cage respiratory muscles, we studied 31 anaesthetized, spontaneously breathing cats. Phrenic activity was used as an index of neural inspiratory drive. Activity of parasternal intercostal (PIM) and triangularis sterni (TS) muscles was recorded. Nicotine in a dose of 65 µg/kg was injected into the left common carotid artery prior to and after midcervical vagotomy, preceded by section of the superior laryngeal nerves (SLNs). In eight additional cats, initially neurotomized as mentioned, nicotine was injected after bilateral disruption of the carotid sinus nerves (CSNs). Nicotine induced prompt expiratory apnoea of mean duration of 5.4±0.3 s in 19 non-vagotomized and of 5.92±0.51 s (mean±S.E.M.) in 13 vagotomized cats. The occurrence and duration of the temporary arrest of breathing were reduced by midcervical vagotomy but not by subsequent CSNs neurotomy, which abolished post-apnoeic acceleration of breathing.In post-nicotine breathing of increased tidal volume and respiratory rate, peak activity of the parasternal intercostal muscles increased from baseline of 3.2±1.2 to 9.5±2.0 arbitrary units (p<0.001). The peak height of the phrenic nerve elevated from 7.9±0.9 to 14.5±1.7 arbitrary units (p<0.001). That of the triangularis sterni showed no change.The response of the respiratory effectors elicited by nicotine was independent of the vagal integrity and may be attributed to activation of nicotine receptors within the brainstem respiratory neurones.

6

Action of serotonin on the laryngeal airway in anaesthetized cats

63%

Szereda-Przestaszewska M., Kopczynska B.

Acta Neurobiologiae Experimentalis

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1997

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tom 57

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nr 3

7

Sposób żywienia młodzieży szkół ponadpodstawowych w Warszawie w latach 1978-1984. Cz.I. Wartość energetyczna i odżywcza

51%

Konieczna W., Kopczynska B., Swiechowska E., Albinowska E.

Żywienie Człowieka i Metabolizm

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1987

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tom 14

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nr 4

8

Wpływ czynników pozaekonomicznych na sposób żywienia młodzieży szkół warszawskich

51%

Narojek L., Kulesza W., Kopczynska B., Szczyglowska M.

Roczniki Państwowego Zakładu Higieny

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1973

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tom 24

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nr 4

39%

Szczyglowa M., Kopczynska B., Kulesza W., Narojek L., Nowicka L., Siczkowna J., Stobnicka-Szczyglowa H.

Roczniki Państwowego Zakładu Higieny

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1972

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tom 23

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nr 1

Ograniczanie wyników

Role of the afferent vagal pathway in modelling of cardio-respiratory response to arvanil in anaesthetized rats

Wpływ kanabinoidów na kształtowanie odpowiedzi oddechowo-ciśnieniowej w modelu zwierzęcym

Ventilatory response to intracarotid serotonin challenge in cats

Apnoeic responses to pulmonary and systemic challenge of capsaicin in cats

Apnoeic responses to intracarotid nicotine challenge in anaesthetized cats

Action of serotonin on the laryngeal airway in anaesthetized cats

Sposób żywienia młodzieży szkół ponadpodstawowych w Warszawie w latach 1978-1984. Cz.I. Wartość energetyczna i odżywcza

Wpływ czynników pozaekonomicznych na sposób żywienia młodzieży szkół warszawskich

Zwierzęcy model lipopolisacharydowego zapalenia płuc

Badania nad sposobem żywienia młodzieży szkół zawodowych Część III. Ocena wyżywienia młodzieży mieszkającej w internatach

Badania nad sposobem żywienia młodzieży szkół zawodowych. Cz. II. Ocena całodziennego żywienia młodzieży uczącej się w szkołach budowlanych, mieszkającej w domach rodzinnych

Ocena sposobu żywienia dzieci i młodzieży szkół warszawskich

Badania nad sposobem żywienia młodzieży szkół zawodowych Część I. Częstotliwość i rozkład posiłków w ciągu dnia oraz spożywanie I i II śniadań

Wybrane zagadnienia dotyczące sposobu żywienia pracowników zatrudnionych w systemie zmianowym

Diverging respiratory effects of serotonin and nicotine in vagotomised cats prior to and after section of carotid sinus nerves

Ocena sposobu żywienia dzieci i młodzieży z wybranych powiatów województwa warszawskiego

Wpływ posiłków regeneracyjnych na skład i wartość odżywcza całodziennego żywienia robotników budowlanych